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CompareOrforglipron vs Semaglutide
Ingredient comparison

Orforglipron vs Semaglutide

Compare the ingredients, then check the specific brand, formulation, and dose. Approved uses and prices vary by product.

Every cash quote was checked on or after Sep 26, 2026.Data feeds · Oct 3, 2026 UTC
OverviewDirect evidenceCash pricesTrial resultsChange comparison
Orforglipron vs Semaglutide: overview
CompareOrforglipronSemaglutide
Brands

Orforglipron

Foundayo

Small-molecule GLP-1

Semaglutide

Ozempic, Wegovy, Wegovy HD, Rybelsus

GLP-1

Route & frequency

Orforglipron

Oral tablet (any time of day, no food or water restriction)

Once daily

What was tested together

Direct comparative evidence

No direct comparative trial is included for these ingredients in our reviewed catalog. The separate trial results below do not establish which works better.

Product-specific self-pay

What the quoted price covers

Lowest tracked quotes for FDA-approved products, selected separately for each price basis. Entry prices may refer to different brands or formulations. Supply periods, eligibility, refill deadlines, and additional fees can change what you pay.

Orforglipron vs Semaglutide: sourced cash quotes
CompareOrforglipronSemaglutide
Advertised entry price

Orforglipron

from $149/mo

Foundayo (LillyDirect self-pay)

LillyDirect (Eli Lilly)

self-pay cash, lowest dose; ~$25/mo with commercial coverage

30-day supply

Separate studies

Trial outcomes in context

Each result belongs to its own trial, population, dose, and analysis. Weight loss, HbA1c change, and adverse events may come from different studies even within one ingredient. These are study averages, not predictions of your result.

Orforglipron vs Semaglutide: individual trial outcomes
CompareOrforglipronSemaglutide
Weight change

Orforglipron

−11.2% (-11.2% at 72 wks · ATTAIN-1 · 17.2 mg daily (Foundayo; 36 mg capsule-equivalent in ATTAIN-1))

-11.2% at 72 wks

ATTAIN-1

17.2 mg daily (Foundayo; 36 mg capsule-equivalent in ATTAIN-1)

Check the product label

Approved uses & full records

Orforglipron

Indications depend on the brand and formulation. Read the product-specific indications and prescribing information in the full record.

53 registered ingredient studies. Count checked Oct 3, 2026. Research activity, not a measure of evidence quality.

Open full record

Semaglutide

Indications depend on the brand and formulation. Read the product-specific indications and prescribing information in the full record.

769 registered ingredient studies. Count checked Oct 3, 2026. Research activity, not a measure of evidence quality.

Open full record
Reading the comparison

Common questions

Which costs less: Orforglipron or Semaglutide?

Compare the named products and price conditions below. A tracked entry quote can be a different brand or formulation from the product studied in a trial. A trial-dose quote applies only to the named product and dose; neither figure is an estimate of your whole treatment cost or an insurance quote.

Do these trial results tell me which medication is best?

Direct trials compare the treatments, doses, and participants they studied. Results from separate trials differ in population, duration, dose, and analysis, so their percentages do not establish a treatment ranking. Discuss your medical history and the specific product label with a licensed clinician.

Does FDA shortage status mean my pharmacy has stock?

No. FDA shortage records describe national supply reports and covered presentations, not inventory at an individual pharmacy. Unknown status means the data cannot establish a current assessment. Confirm local stock with your pharmacy.

Other comparisons
Semaglutide vs TirzepatideSemaglutide vs LiraglutideSemaglutide vs DulaglutideSemaglutide vs ExenatideTirzepatide vs OrforglipronLiraglutide vs Orforglipron

Automated feed checks do not constitute a clinical or editorial review. Sources & methodology

GLPcompare is an informational data platform, not a medical provider or pharmacy. Nothing here is medical advice, a diagnosis, or a recommendation to start, stop, or change any treatment. Data is aggregated from public sources and can be incomplete or out of date. Always confirm with a licensed clinician and the current FDA label.
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The live, fully-cited reference for the GLP-1 ecosystem. Every figure traces to its source. Informational only, not medical advice.

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Fazier

Semaglutide

Subcutaneous injection (Ozempic, Wegovy); oral tablet (Rybelsus, oral Ozempic, Wegovy pill)

Once weekly (injectable); once daily (oral)

FDA shortage report

Orforglipron

National reporting does not confirm stock at your pharmacy.

Coverage & source records

Semaglutide

National reporting does not confirm stock at your pharmacy.

Coverage & source records

$149 per 30 days at this quoted rate

Checked Sep 30, 2026

Price conditions

self-pay cash, lowest dose; ~$25/mo with commercial coverage

The first oral small-molecule GLP-1 pill for weight loss; FDA-approved April 2026. LillyDirect self-pay ladder: $149 (0.8 mg), $199 (2.5 mg), $299 (5.5 and 9 mg), $299 (14.5 and 17.2 mg with a 45-day refill, else $349); the 2.5 mg and 5.5 mg doses are temporarily $149 and $199 through Dec 31, 2026.

30-day supply

Semaglutide

$149-$299/mo

Wegovy pill (oral semaglutide) via GoodRx

GoodRx

by dose; Novo Nordisk's self-pay price through a GoodRx coupon

Third-party reported price

30-day supply

$149 per 30 days at this quoted rate

Checked Sep 30, 2026

Price conditions

by dose; Novo Nordisk's self-pay price through a GoodRx coupon

The same oral semaglutide and prices as the NovoCare offer: $149 (1.5 mg), $199 (4 mg), $299 (9 mg and 25 mg), per Novo Nordisk's published self-pay ladder. FDA-approved product.

30-day supply

At the named trial dose

Orforglipron

$299/mo

Foundayo (LillyDirect self-pay)

At 17.2 mg

LillyDirect (Eli Lilly)

Published price at 17.2 mg

30-day supply

$299 per 30 days at this quoted rate

Checked Sep 30, 2026

Price conditions

Published price at 17.2 mg

The first oral small-molecule GLP-1 pill for weight loss; FDA-approved April 2026. LillyDirect self-pay ladder: $149 (0.8 mg), $199 (2.5 mg), $299 (5.5 and 9 mg), $299 (14.5 and 17.2 mg with a 45-day refill, else $349); the 2.5 mg and 5.5 mg doses are temporarily $149 and $199 through Dec 31, 2026.

Self-Pay Journey price for 14.5 mg and 17.2 mg with a refill within 45 days; regular price $349. Eligibility, additional taxes and fees may apply.

30-day supply

Semaglutide

$349/28 days

Wegovy pen (standard doses 0.25-2.4 mg)

At 2.4 mg

NovoCare (Novo Nordisk)

Published price at 2.4 mg

28-day supply

≈ $373.93 per 30 days at this quoted rate

Checked Sep 30, 2026

Price conditions

Published price at 2.4 mg

After the introductory offer, standard doses cost $349 per box of four weekly pens. Wegovy HD (7.2 mg) is $399. Eligibility and restrictions apply.

One price for every standard dose (0.25-2.4 mg).

28-day supply

Explore product prices

Orforglipron

All Orforglipron offers

Semaglutide

All Semaglutide offers

USD self-pay, not insurance or pharmacy acquisition cost. A trial dose is not a personal dosing recommendation. Compounded offers are shown separately in the offer browser and are not FDA-approved.

Accounts for treatment discontinuation

Study context

The first oral small-molecule GLP-1 pill for weight loss (Foundayo, FDA-approved April 2026): pill convenience with injectable-class efficacy. -11.2% is the primary (treatment-regimen) endpoint; the efficacy estimand was -12.4%.

Semaglutide

−14.9% (-14.9% at 68 wks · STEP 1 · 2.4 mg weekly (Wegovy))

-14.9% at 68 wks

STEP 1

2.4 mg weekly (Wegovy)

Accounts for treatment discontinuation

Study context

The headline is the standard 2.4 mg maintenance dose (Wegovy), the dose used in STEP 1 and one of the permitted doses in SURMOUNT-5. Other doses and formulations have their own trials, including STEP UP and OASIS 4. Their results are not interchangeable.

HbA1c change (percentage points)

Orforglipron

−1.5 pp (-1.5 percentage points at 40 wks (36 mg, ACHIEVE-1) · ACHIEVE-1 · HbA1c change in percentage points)

-1.5 percentage points at 40 wks (36 mg, ACHIEVE-1)

ACHIEVE-1
Study context

The first oral small-molecule GLP-1 pill for weight loss (Foundayo, FDA-approved April 2026): pill convenience with injectable-class efficacy. -11.2% is the primary (treatment-regimen) endpoint; the efficacy estimand was -12.4%.

Semaglutide

−1.6 pp (-1.6% at 68 wks · STEP 2 · HbA1c change in percentage points)

-1.6 percentage points at 68 wks

STEP 2
Study context

The headline is the standard 2.4 mg maintenance dose (Wegovy), the dose used in STEP 1 and one of the permitted doses in SURMOUNT-5. Other doses and formulations have their own trials, including STEP UP and OASIS 4. Their results are not interchangeable.

Adverse events

Orforglipron

Stopped treatment for adverse events

10.3% (10.3% vs 2.7% placebo (36 mg) · ATTAIN-1 (36 mg, 72 wks, obesity))

Reported nausea

33.7% (Nausea in the drug arm · ATTAIN-1 (36 mg, 72 wks, obesity))

ATTAIN-1 (36 mg, 72 wks, obesity)

Semaglutide

Stopped treatment for adverse events

7% (7.0% vs 3.1% placebo · STEP 1 (2.4 mg, 68 wks, obesity))

Reported nausea

44.2% (Nausea in the drug arm · STEP 1 (2.4 mg, 68 wks, obesity))

STEP 1 (2.4 mg, 68 wks, obesity)