GLPcompareGLPcompare
DrugsPricesCompareShortagesEvidenceSupplementsWatchlist
CompareLiraglutide vs Semaglutide
Ingredient comparison

Liraglutide vs Semaglutide

Compare the ingredients, then check the specific brand, formulation, and dose. Approved uses and prices vary by product.

Every cash quote was checked on or after Sep 26, 2026.Data feeds · Oct 3, 2026 UTC
OverviewDirect evidenceCash pricesTrial resultsChange comparison
Liraglutide vs Semaglutide: overview
CompareLiraglutideSemaglutide
Brands

Liraglutide

Victoza, Saxenda

GLP-1

Semaglutide

Ozempic, Wegovy, Wegovy HD, Rybelsus

GLP-1

Route & frequency

Liraglutide

Subcutaneous injection

Once daily

Semaglutide

What was tested together

Direct comparative evidence

No direct comparative trial is included for these ingredients in our reviewed catalog. The separate trial results below do not establish which works better.

Product-specific self-pay

What the quoted price covers

Lowest tracked quotes for FDA-approved products, selected separately for each price basis. Entry prices may refer to different brands or formulations. Supply periods, eligibility, refill deadlines, and additional fees can change what you pay.

Liraglutide vs Semaglutide: sourced cash quotes
CompareLiraglutideSemaglutide
Advertised entry price

Liraglutide

~$372/mo

Generic liraglutide 3 mg pens (Saxenda generic), GoodRx coupon

GoodRx

GoodRx coupon, lowest listed price for one carton of five 18 mg/3 mL pens

Third-party reported price

Supply period unverified; excluded from cost ranking.

Separate studies

Trial outcomes in context

Each result belongs to its own trial, population, dose, and analysis. Weight loss, HbA1c change, and adverse events may come from different studies even within one ingredient. These are study averages, not predictions of your result.

Liraglutide vs Semaglutide: individual trial outcomes
CompareLiraglutideSemaglutide
Weight change

Liraglutide

−8% (-8.0% at 56 wks · SCALE Obesity · 3.0 mg daily (Saxenda))

-8.0% at 56 wks

SCALE Obesity

3.0 mg daily (Saxenda)

Analysis not classified; see trial methods

Check the product label

Approved uses & full records

Liraglutide

Indications depend on the brand and formulation. Read the product-specific indications and prescribing information in the full record.

514 registered ingredient studies. Count checked Oct 3, 2026. Research activity, not a measure of evidence quality.

Open full record

Semaglutide

Indications depend on the brand and formulation. Read the product-specific indications and prescribing information in the full record.

769 registered ingredient studies. Count checked Oct 3, 2026. Research activity, not a measure of evidence quality.

Open full record
Reading the comparison

Common questions

Which costs less: Liraglutide or Semaglutide?

Compare the named products and price conditions below. A tracked entry quote can be a different brand or formulation from the product studied in a trial. A trial-dose quote applies only to the named product and dose; neither figure is an estimate of your whole treatment cost or an insurance quote.

Do these trial results tell me which medication is best?

Direct trials compare the treatments, doses, and participants they studied. Results from separate trials differ in population, duration, dose, and analysis, so their percentages do not establish a treatment ranking. Discuss your medical history and the specific product label with a licensed clinician.

Does FDA shortage status mean my pharmacy has stock?

No. FDA shortage records describe national supply reports and covered presentations, not inventory at an individual pharmacy. Unknown status means the data cannot establish a current assessment. Confirm local stock with your pharmacy.

Other comparisons
Semaglutide vs TirzepatideSemaglutide vs DulaglutideSemaglutide vs ExenatideSemaglutide vs OrforglipronTirzepatide vs LiraglutideLiraglutide vs Dulaglutide

Automated feed checks do not constitute a clinical or editorial review. Sources & methodology

GLPcompare is an informational data platform, not a medical provider or pharmacy. Nothing here is medical advice, a diagnosis, or a recommendation to start, stop, or change any treatment. Data is aggregated from public sources and can be incomplete or out of date. Always confirm with a licensed clinician and the current FDA label.
GLPcompareGLPcompare

The live, fully-cited reference for the GLP-1 ecosystem. Every figure traces to its source. Informational only, not medical advice.

Product

  • Drugs
  • Prices
  • Compare
  • Shortages
  • Evidence
  • Supplements

Legal

  • Methodology
  • About
  • News
  • Price updates
  • Privacy Policy
  • Terms of Service
  • Support

Some outbound links on GLPcompare are referral links. If you sign up or buy through one, we may earn a commission at no extra cost to you. It never changes the price you pay or the underlying data. Partner status and commission rates contribute to offer and provider value scores and can change their order. Every partner is labeled. Value scores are not medical recommendations; a higher-ranked offer is not necessarily the lowest price or the right product for you.

© 2026 GLPcompare. All rights reserved.

Fazier

Subcutaneous injection (Ozempic, Wegovy); oral tablet (Rybelsus, oral Ozempic, Wegovy pill)

Once weekly (injectable); once daily (oral)

FDA shortage report

Liraglutide

In shortage

National reporting does not confirm stock at your pharmacy.

Coverage & source records

Semaglutide

National reporting does not confirm stock at your pharmacy.

Coverage & source records
Checked Sep 30, 2026
Price conditions

GoodRx coupon, lowest listed price for one carton of five 18 mg/3 mL pens

GoodRx lists brand Saxenda separately; this is its generic liraglutide listing (Teva launched the first generic GLP-1 for weight loss in August 2025). Prices vary by pharmacy.

Semaglutide

$149-$299/mo

Wegovy pill (oral semaglutide) via GoodRx

GoodRx

by dose; Novo Nordisk's self-pay price through a GoodRx coupon

Third-party reported price

30-day supply

$149 per 30 days at this quoted rate

Checked Sep 30, 2026

Price conditions

by dose; Novo Nordisk's self-pay price through a GoodRx coupon

The same oral semaglutide and prices as the NovoCare offer: $149 (1.5 mg), $199 (4 mg), $299 (9 mg and 25 mg), per Novo Nordisk's published self-pay ladder. FDA-approved product.

30-day supply

At the named trial dose

Liraglutide

~$372/mo

Generic liraglutide 3 mg pens (Saxenda generic), GoodRx coupon

At 3 mg

GoodRx

Published price at 3 mg

Third-party reported price

Supply period unverified; excluded from cost ranking.

Checked Sep 30, 2026

Price conditions

Published price at 3 mg

GoodRx lists brand Saxenda separately; this is its generic liraglutide listing (Teva launched the first generic GLP-1 for weight loss in August 2025). Prices vary by pharmacy.

Five pens hold 90 mg: 30 days at the 3 mg daily dose.

Semaglutide

$349/28 days

Wegovy pen (standard doses 0.25-2.4 mg)

At 2.4 mg

NovoCare (Novo Nordisk)

Published price at 2.4 mg

28-day supply

≈ $373.93 per 30 days at this quoted rate

Checked Sep 30, 2026

Price conditions

Published price at 2.4 mg

After the introductory offer, standard doses cost $349 per box of four weekly pens. Wegovy HD (7.2 mg) is $399. Eligibility and restrictions apply.

One price for every standard dose (0.25-2.4 mg).

28-day supply

Explore product prices

Liraglutide

All Liraglutide offers

Semaglutide

All Semaglutide offers

USD self-pay, not insurance or pharmacy acquisition cost. A trial dose is not a personal dosing recommendation. Compounded offers are shown separately in the offer browser and are not FDA-approved.

Semaglutide

−14.9% (-14.9% at 68 wks · STEP 1 · 2.4 mg weekly (Wegovy))

-14.9% at 68 wks

STEP 1

2.4 mg weekly (Wegovy)

Accounts for treatment discontinuation

Study context

The headline is the standard 2.4 mg maintenance dose (Wegovy), the dose used in STEP 1 and one of the permitted doses in SURMOUNT-5. Other doses and formulations have their own trials, including STEP UP and OASIS 4. Their results are not interchangeable.

HbA1c change (percentage points)

Liraglutide

−1.3 pp (-1.3% at 56 wks · SCALE Diabetes · HbA1c change in percentage points)

-1.3 percentage points at 56 wks

SCALE Diabetes

Semaglutide

−1.6 pp (-1.6% at 68 wks · STEP 2 · HbA1c change in percentage points)

-1.6 percentage points at 68 wks

STEP 2
Study context

The headline is the standard 2.4 mg maintenance dose (Wegovy), the dose used in STEP 1 and one of the permitted doses in SURMOUNT-5. Other doses and formulations have their own trials, including STEP UP and OASIS 4. Their results are not interchangeable.

Adverse events

Liraglutide

Stopped treatment for adverse events

9.8% (9.8% vs 4.3% placebo (3.0 mg) · FDA Saxenda label, pooled 3.0 mg obesity trials (SCALE))

Reported nausea

39.3% (Nausea in the drug arm · FDA Saxenda label, pooled 3.0 mg obesity trials (SCALE))

FDA Saxenda label, pooled 3.0 mg obesity trials (SCALE)

from the FDA Saxenda adverse-reactions table (the SCALE Obesity trial paper is paywalled); essentially identical to the trial's own ~9.9% / ~40% figures

Semaglutide

Stopped treatment for adverse events

7% (7.0% vs 3.1% placebo · STEP 1 (2.4 mg, 68 wks, obesity))

Reported nausea

44.2% (Nausea in the drug arm · STEP 1 (2.4 mg, 68 wks, obesity))

STEP 1 (2.4 mg, 68 wks, obesity)