Ozempic vs Zepbound
Change comparisonOzempic contains semaglutide. Zepbound contains tirzepatide. Compare approved uses, formulations, and self-pay prices.
| Compare | Ozempic | Zepbound |
|---|---|---|
| Active ingredient | SemaglutideGLP-1 | TirzepatideGIP/GLP-1 |
| How it is taken | Injection Once weekly Tablet Once daily, on an empty stomach | Injection Once weekly |
| Manufacturer | Novo Nordisk | Eli Lilly |
What was actually compared
No direct trial comparing these exact brands is included in our reviewed catalog. Results from separate trials are not a direct comparison of these products.
Weight-loss results by formulation
Each result belongs to its named trial and dose. Separate trials have different participants and methods; these figures are not a direct comparison.
| Compare | Ozempic | Zepbound |
|---|---|---|
| Injection evidence | No reviewed weight-loss result for this brand and formulation. | −20.9% (-20.9% at 72 wks · SURMOUNT-1 · 15 mg weekly (Zepbound)) SURMOUNT-1 · -20.9% at 72 wks 15 mg weekly (Zepbound) Accounts for treatment discontinuation |
| Tablet evidence | No reviewed weight-loss result for this brand and formulation. | No reviewed weight-loss result for this brand and formulation. |
Entry price and maintenance price
Self-pay quotes, not insurance estimates. Each figure identifies the product, provider, and dose where published.
| Compare | Ozempic | Zepbound |
|---|---|---|
| Injection prices | Advertised entry price $199/fill initially≈ $213.21 per 30 days at this quoted rate Offer through Checked Ozempic pen NovoCare (Novo Nordisk) · Manufacturer direct first two monthly fills at 0.25 or 0.5 mg for new patients, prescribed by Dec 31, 2026 Price conditionsfirst two monthly fills at 0.25 or 0.5 mg for new patients, prescribed by Dec 31, 2026 After the introductory offer: $349 per monthly fill for 0.25, 0.5, or 1 mg; $499 for 2 mg. NovoCare defines one injection fill as a 28-day supply. Eligibility and restrictions apply. 28-day supply Published maintenance dose $499/28 days≈ $534.64 per 30 days at this quoted rate Checked At 2 mg Ozempic pen NovoCare (Novo Nordisk) · Manufacturer direct Published price at 2 mg Price conditionsPublished price at 2 mg After the introductory offer: $349 per monthly fill for 0.25, 0.5, or 1 mg; $499 for 2 mg. NovoCare defines one injection fill as a 28-day supply. Eligibility and restrictions apply. 28-day supply | Advertised entry price $299-$449/28 days≈ $320.36 per 30 days at this quoted rate Checked Zepbound KwikPen (multi-dose pen) LillyDirect (Eli Lilly) · Manufacturer direct self-pay cash, by dose ($299 / $399 / $449) Price conditionsself-pay cash, by dose ($299 / $399 / $449) Four weekly doses per pen; pen needles must be purchased separately. $299 at 2.5 mg, $399 at 5 mg, and $449 at higher doses under the Self Pay Journey offer with a refill within 45 days. 28-day supply Published maintenance dose $449/28 days≈ $481.07 per 30 days at this quoted rate Checked At 15 mg Zepbound KwikPen (multi-dose pen) LillyDirect (Eli Lilly) · Manufacturer direct Published price at 15 mg Price conditionsPublished price at 15 mg Four weekly doses per pen; pen needles must be purchased separately. $299 at 2.5 mg, $399 at 5 mg, and $449 at higher doses under the Self Pay Journey offer with a refill within 45 days. Self Pay Journey price for 7.5-15 mg with a refill within 45 days; otherwise $499 (7.5 mg) or $699 (10-15 mg). Pen needles cost extra. 28-day supply |
| Tablet prices | Advertised entry price $149/30 days$149 per 30 days at this quoted rate Checked Ozempic tablets NovoCare (Novo Nordisk) · Manufacturer direct self-pay, 1.5 mg starting dose Price conditionsself-pay, 1.5 mg starting dose A prescription is required. The 1.5 mg initiation dose costs $149 for 30 tablets. Self-pay purchases are processed outside insurance and do not count toward deductibles or out-of-pocket limits. Ozempic tablet prices are separate from Wegovy tablet prices. 30-day supply Published maintenance dose $299/30 days$299 per 30 days at this quoted rate Checked At 9 mg Ozempic tablets NovoCare (Novo Nordisk) · Manufacturer direct Published price at 9 mg Price conditionsPublished price at 9 mg A prescription is required. The 1.5 mg initiation dose costs $149 for 30 tablets. Self-pay purchases are processed outside insurance and do not count toward deductibles or out-of-pocket limits. Ozempic tablet prices are separate from Wegovy tablet prices. 30 tablets per bottle. The 4 mg strength costs $199 per 30-day fill; 9 mg costs $299. 30-day supply | No reviewed tablet formulation in this brand record. |
How these quotes are selected
For each price basis, we prefer a recently checked manufacturer-direct quote, then a recently checked provider quote for that brand and formulation. Within each group, documented 30-day costs come first, lowest to highest. Quotes without a documented supply period have no cost rank. Older quotes appear as dated references only when no current quote is tracked. Providers may differ between entry and maintenance prices. Missing maintenance prices are never replaced with entry prices. Compounded products, combined brand quotes, and membership-only fees are excluded. Prices at different doses are not equivalent treatment costs; confirm supply length, eligibility, and added fees.
Every cash quote was checked on or after . Each quote shows its own check date. A quoted maintenance dose is not a dosing recommendation. Our methodology
Approved uses by formulation
Eligibility, contraindications, and warnings are in each product's full prescribing information.
| Compare | Ozempic | Zepbound |
|---|---|---|
| Injection | Adults with type 2 diabetes: glucose control; cardiovascular risk reduction with established cardiovascular disease; kidney and cardiovascular protection with chronic kidney disease. US prescribing information (Ozempic Injection prescribing information)Reviewed Sep 6, 2026 | Weight management in adults with obesity, or overweight with a weight-related condition; moderate to severe obstructive sleep apnea in adults with obesity. US prescribing information (Zepbound Injection prescribing information)Reviewed Sep 6, 2026 |
| Tablet | Adults with type 2 diabetes: glucose control and cardiovascular risk reduction in those at high risk. The tablet label does not include the injection's kidney indication. US prescribing information (Ozempic Tablet prescribing information)Reviewed Sep 6, 2026 | No reviewed tablet label in this brand record. Ingredient record |