Ozempic vs Trulicity
Change comparisonOzempic contains semaglutide. Trulicity contains dulaglutide. Compare approved uses, formulations, and self-pay prices.
| Compare | Ozempic | Trulicity |
|---|---|---|
| Active ingredient | SemaglutideGLP-1 | DulaglutideGLP-1 |
| How it is taken | Injection Once weekly Tablet Once daily, on an empty stomach | Injection Once weekly |
| Manufacturer | Novo Nordisk | Eli Lilly |
What was actually compared
No direct trial comparing these exact brands is included in our reviewed catalog. Results from separate trials are not a direct comparison of these products.
Weight-loss results by formulation
Each result belongs to its named trial and dose. Separate trials have different participants and methods; these figures are not a direct comparison.
| Compare | Ozempic | Trulicity |
|---|---|---|
| Injection evidence | No reviewed weight-loss result for this brand and formulation. | ≈−4% (-4.6 kg (~4%) at 36 wks · AWARD-11 · 4.5 mg weekly (Trulicity)) AWARD-11 · -4.6 kg (~4%) at 36 wks 4.5 mg weekly (Trulicity) Approximation from kilograms; see trial methods |
| Tablet evidence | No reviewed weight-loss result for this brand and formulation. | No reviewed weight-loss result for this brand and formulation. |
Entry price and maintenance price
Self-pay quotes, not insurance estimates. Each figure identifies the product, provider, and dose where published.
| Compare | Ozempic | Trulicity |
|---|---|---|
| Injection prices | Advertised entry price $199/fill initially≈ $213.21 per 30 days at this quoted rate Offer through Checked Ozempic pen NovoCare (Novo Nordisk) · Manufacturer direct first two monthly fills at 0.25 or 0.5 mg for new patients, prescribed by Dec 31, 2026 Price conditionsfirst two monthly fills at 0.25 or 0.5 mg for new patients, prescribed by Dec 31, 2026 After the introductory offer: $349 per monthly fill for 0.25, 0.5, or 1 mg; $499 for 2 mg. NovoCare defines one injection fill as a 28-day supply. Eligibility and restrictions apply. 28-day supply Published maintenance dose $499/28 days≈ $534.64 per 30 days at this quoted rate Checked At 2 mg Ozempic pen NovoCare (Novo Nordisk) · Manufacturer direct Published price at 2 mg Price conditionsPublished price at 2 mg After the introductory offer: $349 per monthly fill for 0.25, 0.5, or 1 mg; $499 for 2 mg. NovoCare defines one injection fill as a 28-day supply. Eligibility and restrictions apply. 28-day supply | Advertised entry price from $389/28 days≈ $416.79 per 30 days at this quoted rate Checked Trulicity single-dose pens LillyDirect (Eli Lilly) · Manufacturer direct self-pay, four weekly pens; published starting rate at each dose Price conditionsself-pay, four weekly pens; published starting rate at each dose The self-pay program requires a prescription for an approved use, age 18+, and US or Puerto Rico residence. Purchases cannot be submitted to insurance or counted toward deductibles or out-of-pocket limits. Four once-weekly pens cover 28 days. 28-day supply Published maintenance dose from $389/28 days≈ $416.79 per 30 days at this quoted rate Checked At 4.5 mg Trulicity single-dose pens LillyDirect (Eli Lilly) · Manufacturer direct Published price at 4.5 mg Price conditionsPublished price at 4.5 mg The self-pay program requires a prescription for an approved use, age 18+, and US or Puerto Rico residence. Purchases cannot be submitted to insurance or counted toward deductibles or out-of-pocket limits. Four once-weekly pens cover 28 days. The same starting rate is published for 0.75, 1.5, 3 and 4.5 mg. Taxes and additional fees may apply. 28-day supply |
| Tablet prices | Advertised entry price $149/30 days$149 per 30 days at this quoted rate Checked Ozempic tablets NovoCare (Novo Nordisk) · Manufacturer direct self-pay, 1.5 mg starting dose Price conditionsself-pay, 1.5 mg starting dose A prescription is required. The 1.5 mg initiation dose costs $149 for 30 tablets. Self-pay purchases are processed outside insurance and do not count toward deductibles or out-of-pocket limits. Ozempic tablet prices are separate from Wegovy tablet prices. 30-day supply Published maintenance dose $299/30 days$299 per 30 days at this quoted rate Checked At 9 mg Ozempic tablets NovoCare (Novo Nordisk) · Manufacturer direct Published price at 9 mg Price conditionsPublished price at 9 mg A prescription is required. The 1.5 mg initiation dose costs $149 for 30 tablets. Self-pay purchases are processed outside insurance and do not count toward deductibles or out-of-pocket limits. Ozempic tablet prices are separate from Wegovy tablet prices. 30 tablets per bottle. The 4 mg strength costs $199 per 30-day fill; 9 mg costs $299. 30-day supply | No reviewed tablet formulation in this brand record. |
How these quotes are selected
For each price basis, we prefer a recently checked manufacturer-direct quote, then a recently checked provider quote for that brand and formulation. Within each group, documented 30-day costs come first, lowest to highest. Quotes without a documented supply period have no cost rank. Older quotes appear as dated references only when no current quote is tracked. Providers may differ between entry and maintenance prices. Missing maintenance prices are never replaced with entry prices. Compounded products, combined brand quotes, and membership-only fees are excluded. Prices at different doses are not equivalent treatment costs; confirm supply length, eligibility, and added fees.
Every cash quote was checked on or after . Each quote shows its own check date. A quoted maintenance dose is not a dosing recommendation. Our methodology
Approved uses by formulation
Eligibility, contraindications, and warnings are in each product's full prescribing information.
| Compare | Ozempic | Trulicity |
|---|---|---|
| Injection | Adults with type 2 diabetes: glucose control; cardiovascular risk reduction with established cardiovascular disease; kidney and cardiovascular protection with chronic kidney disease. US prescribing information (Ozempic Injection prescribing information)Reviewed Sep 6, 2026 | Glucose control in adults and children 10+ with type 2 diabetes; cardiovascular risk reduction in adults with type 2 diabetes and established cardiovascular disease or multiple cardiovascular risk factors. US prescribing information (Trulicity Injection prescribing information)Reviewed Sep 22, 2026 |
| Tablet | Adults with type 2 diabetes: glucose control and cardiovascular risk reduction in those at high risk. The tablet label does not include the injection's kidney indication. US prescribing information (Ozempic Tablet prescribing information)Reviewed Sep 6, 2026 | No reviewed tablet label in this brand record. Ingredient record |