Ozempic vs Rybelsus
Change comparisonThese brands contain semaglutide. Compare their approved uses, formulations, and self-pay prices. Products are not interchangeable.
| Compare | Ozempic | Rybelsus |
|---|---|---|
| Active ingredient | SemaglutideGLP-1 | SemaglutideGLP-1 |
| How it is taken | Injection Once weekly Tablet Once daily, on an empty stomach | Tablet Once daily, on an empty stomach |
| Manufacturer | Novo Nordisk | Novo Nordisk |
What was actually compared
No direct trial comparing these exact brands is included in our reviewed catalog. Sharing an ingredient does not establish the same outcomes at different doses or formulations.
Weight-loss results by formulation
Each result belongs to its named trial and dose. Separate trials have different participants and methods; these figures are not a direct comparison.
| Compare | Ozempic | Rybelsus |
|---|---|---|
| Injection evidence | No reviewed weight-loss result for this brand and formulation. | No reviewed weight-loss result for this brand and formulation. |
| Tablet evidence | No reviewed weight-loss result for this brand and formulation. | No reviewed weight-loss result for this brand and formulation. |
Entry price and maintenance price
Self-pay quotes, not insurance estimates. Each figure identifies the product, provider, and dose where published.
| Compare | Ozempic | Rybelsus |
|---|---|---|
| Injection prices | Advertised entry price $199/fill initially≈ $213.21 per 30 days at this quoted rate Offer through Checked Ozempic pen NovoCare (Novo Nordisk) · Manufacturer direct first two monthly fills at 0.25 or 0.5 mg for new patients, prescribed by Dec 31, 2026 Price conditionsfirst two monthly fills at 0.25 or 0.5 mg for new patients, prescribed by Dec 31, 2026 After the introductory offer: $349 per monthly fill for 0.25, 0.5, or 1 mg; $499 for 2 mg. NovoCare defines one injection fill as a 28-day supply. Eligibility and restrictions apply. 28-day supply Published maintenance dose $499/28 days≈ $534.64 per 30 days at this quoted rate Checked At 2 mg Ozempic pen NovoCare (Novo Nordisk) · Manufacturer direct Published price at 2 mg Price conditionsPublished price at 2 mg After the introductory offer: $349 per monthly fill for 0.25, 0.5, or 1 mg; $499 for 2 mg. NovoCare defines one injection fill as a 28-day supply. Eligibility and restrictions apply. 28-day supply | No reviewed injection formulation in this brand record. |
| Tablet prices | Advertised entry price $149/30 days$149 per 30 days at this quoted rate Checked Ozempic tablets NovoCare (Novo Nordisk) · Manufacturer direct self-pay, 1.5 mg starting dose Price conditionsself-pay, 1.5 mg starting dose A prescription is required. The 1.5 mg initiation dose costs $149 for 30 tablets. Self-pay purchases are processed outside insurance and do not count toward deductibles or out-of-pocket limits. Ozempic tablet prices are separate from Wegovy tablet prices. 30-day supply Published maintenance dose $299/30 days$299 per 30 days at this quoted rate Checked At 9 mg Ozempic tablets NovoCare (Novo Nordisk) · Manufacturer direct Published price at 9 mg Price conditionsPublished price at 9 mg A prescription is required. The 1.5 mg initiation dose costs $149 for 30 tablets. Self-pay purchases are processed outside insurance and do not count toward deductibles or out-of-pocket limits. Ozempic tablet prices are separate from Wegovy tablet prices. 30 tablets per bottle. The 4 mg strength costs $199 per 30-day fill; 9 mg costs $299. 30-day supply | Advertised entry price No product-specific quote tracked. Published maintenance dose No dose-specific quote tracked. |
How these quotes are selected
For each price basis, we prefer a recently checked manufacturer-direct quote, then a recently checked provider quote for that brand and formulation. Within each group, documented 30-day costs come first, lowest to highest. Quotes without a documented supply period have no cost rank. Older quotes appear as dated references only when no current quote is tracked. Providers may differ between entry and maintenance prices. Missing maintenance prices are never replaced with entry prices. Compounded products, combined brand quotes, and membership-only fees are excluded. Prices at different doses are not equivalent treatment costs; confirm supply length, eligibility, and added fees.
Every cash quote was checked on or after . Each quote shows its own check date. A quoted maintenance dose is not a dosing recommendation. Our methodology
Approved uses by formulation
Eligibility, contraindications, and warnings are in each product's full prescribing information.
| Compare | Ozempic | Rybelsus |
|---|---|---|
| Injection | Adults with type 2 diabetes: glucose control; cardiovascular risk reduction with established cardiovascular disease; kidney and cardiovascular protection with chronic kidney disease. US prescribing information (Ozempic Injection prescribing information)Reviewed Sep 6, 2026 | No reviewed injection label in this brand record. Ingredient record |
| Tablet | Adults with type 2 diabetes: glucose control and cardiovascular risk reduction in those at high risk. The tablet label does not include the injection's kidney indication. US prescribing information (Ozempic Tablet prescribing information)Reviewed Sep 6, 2026 | Adults with type 2 diabetes: glucose control and cardiovascular risk reduction in those at high risk. Rybelsus and Ozempic tablets are not substitutable milligram for milligram. US prescribing information (Rybelsus Tablet prescribing information)Reviewed Sep 6, 2026 |