NCT00781937 trial results

Inclusion Criteria: * Body Mass Index (BMI) of either 30 kg/m\^2 or more or BMI of less than 30 kg/m\^2 to 27 kg/m\^2 with presence of co-morbidities * Stable body weight during the previous 3 months (less than 5 kg self-reported weight change) * Previously undergone dietary weight loss and was not able to maintain reduced weight Exclusion Criteria: * Diagnosis of type 1 or type 2 diabetes * Previous treatment with GLP-1 (glucagon-like peptide-1) receptor agonists (including liraglutide or exenatide), within the last 3 months * Visit 1 thryoid stimulating hormone (TSH) outside of the range of 0.4-6.0 mIU/L * History of chronic pancreatitis or idiopathic acute pancreatitis * Obesity induced by other endocrinologic disorders (e.g., Cushing Syndrome) * Current or history of treatment with medications that may cause significant weight gain for at least 3 months before this trial * Current participation in an organized diet reduction program (or within the last 3 months) * Currently using or have used within three months before this trial: pramlintide, sibutramine, orlistat, zonisamide, topiramate, phenteremine, or metformin * Previous surgical treatment for obesity (excluding liposuction if performed more than one year before trial entry) * History of major depressive disorder or a PHQ-9 (Patient Health Questionnaire-9) score of more than 15 within the last 2 years or history of other severe psychiatric disorders or diagnosis of an eating disorder * Subjects with a lifetime history of a suicide attempt or history of any suicidal behavior within the past month before entry into the trial