GLP-1 results compared
11 medicines, each with its own trial, dose and length. These are separate trials, not a head-to-head ranking; the evidence page shows the trials that compared two directly.
Weight loss by medicine
| Medicine | Status | Dose | Weight | Trial | A1c |
|---|---|---|---|---|---|
| Retatrutide | Investigational | 12 mg weekly (TRIUMPH-1) | -28.3% at 80 wks | TRIUMPH-1 (Phase 3) | -1.5% at 12 mg (TRIUMPH-2, Phase 3 T2D) |
| Amycretin | Investigational | 60 mg weekly (Phase 1b/2a) | -24.3% at 36 wks | Phase 1b/2a (subcutaneous) | Not reported (obesity trial) |
| CagriSema | Investigational | 2.4 mg / 2.4 mg weekly (CagriSema) | -22.7% at 68 wks | REDEFINE-1 (Phase 3) | -1.91 percentage points at 68 wks (REIMAGINE 2, type 2 diabetes, assuming adherence) |
| Tirzepatide | Approved | 15 mg weekly (Zepbound) | -20.9% at 72 wks | SURMOUNT-1 | -2.3% at 40 wks |
| Survodutide | Investigational | 6.0 mg weekly (Phase 3) | -16.6% at 76 wks | SYNCHRONIZE-1 (Phase 3) | -0.8 percentage points at 76 wks (6.0 mg; SYNCHRONIZE-2, type 2 diabetes) |
| MariTide | Investigational | Highest dose, monthly (Phase 2) | -16.2% at 52 wks | Phase 2 obesity | Not reported (obesity trial) |
| Semaglutide | Approved | 2.4 mg weekly (Wegovy) | -14.9% at 68 wks | STEP 1 | -1.6% at 68 wks |
| Orforglipron | Approved | 17.2 mg daily (Foundayo; 36 mg capsule-equivalent in ATTAIN-1) | -11.2% at 72 wks | ATTAIN-1 | -1.5 percentage points at 40 wks (36 mg, ACHIEVE-1) |
| Liraglutide | Approved | 3.0 mg daily (Saxenda) | -8.0% at 56 wks | SCALE Obesity | -1.3% at 56 wks |
| Dulaglutide | Approved | 4.5 mg weekly (Trulicity) | -4.6 kg (~4%) at 36 wks | AWARD-11 | -1.9% at 36 wks |
| Exenatide | Approved | 2 mg weekly (Bydureon) | -3.7 kg (~3.6%) at 30 wks | DURATION-1 | -1.9% at 30 wks |
GLP-1 results: common questions
Which GLP-1 causes the most weight loss?
Among approved medicines here, the largest mean weight loss in a pivotal trial is Tirzepatide (-20.9% at 72 wks in SURMOUNT-1, 15 mg weekly (Zepbound)). Those are separate trials with different people and lengths: the head-to-head trials on the evidence page are the direct comparison.
How long does a GLP-1 take to work?
Trials measure weight at their endpoint, usually 68 to 72 weeks, after the dose has been raised step by step over the first months. The dose schedule is on each brand's dosing page, and each label's clinical studies section shows how weight changed over a trial. How long each GLP-1 takes, week by week