Trulicity dosage
The recommended starting dosage of TRULICITY is 0.75 mg injected subcutaneously once weekly. The maximum recommended dosage is 4.5 mg injected subcutaneously once weekly.
Word for word from the FDA label on DailyMed (Eli Lilly and Company), revised , version 62. Read every day: a new FDA version updates this page by itself.
Trulicity dosage chart
The soonest the label's schedule allows. A clinician can go slower.
| When | Dose |
|---|---|
| Weeks 1 to 4 | 0.75 mg |
| Week 5 or later | 1.5 mgif more control is needed |
| Week 9 or later | 3 mgif more control is needed |
| Week 13 or later | 4.5 mgif more control is needed |
Trulicity dosing and administration
Adult Dosage
- The recommended starting dosage of TRULICITY is 0.75 mg injected subcutaneously once weekly. Follow the dosage escalation below to reduce the risk of gastrointestinal adverse reactions [see Warnings and Precautions (5.6) and Adverse Reactions (6.1)].
- After 4 weeks, the dosage may be increased to 1.5 mg once weekly for additional glycemic control.
- If additional glycemic control is needed, increase the dosage in 1.5 mg increments after at least 4 weeks on the current dosage.
- The maximum recommended dosage is 4.5 mg injected subcutaneously once weekly.
Pediatric Dosage
- The recommended starting dosage of TRULICITY is 0.75 mg injected subcutaneously once weekly.
- If additional glycemic control is needed, increase the dosage to the maximum recommended dosage of 1.5 mg once weekly after at least 4 weeks on the 0.75 mg dosage to reduce the risk of gastrointestinal adverse reactions [see Warnings and Precautions (5.6) and Adverse Reactions (6.1)] .
Recommendations Regarding Missed Dose
- If a dose is missed, instruct patients to administer the dose as soon as possible if there are at least 3 days (72 hours) until the next scheduled dose. If less than 3 days remain before the next scheduled dose, skip the missed dose and administer the next dose on the regularly scheduled day. In each case, patients can then resume their regular once weekly dosing schedule.
- The day of weekly administration can be changed, if necessary, as long as the last dose was administered 3 or more days before the new day of administration.
Important Administration Instructions
- Prior to initiation, train patients and caregivers on proper injection technique [see Instructions for Use] .
- Administer TRULICITY once weekly, any time of day, with or without food.
- Inject TRULICITY subcutaneously in the abdomen, thigh, or upper arm.
- Rotate injection sites with each dose.
- Inspect TRULICITY visually before use. It should appear clear and colorless. Do not use TRULICITY if particulate matter or coloration is seen.
- When using TRULICITY with insulin, administer as separate injections and never mix. It is acceptable to inject TRULICITY and insulin in the same body region, but the injections should not be adjacent to each other.
Source: Trulicity prescribing information (FDA label on DailyMed), revised 2026-06-16
Trulicity strengths and forms
Injection: TRULICITY is a clear and colorless solution available as:
- 0.75 mg/0.5 mL solution in a single-dose pen
- 1.5 mg/0.5 mL solution in a single-dose pen
- 3 mg/0.5 mL solution in a single-dose pen
- 4.5 mg/0.5 mL solution in a single-dose pen
Source: Trulicity prescribing information (FDA label on DailyMed), revised 2026-06-16
How to store Trulicity
How Supplied
TRULICITY (dulaglutide) injection is a clear and colorless solution supplied in single-dose pens. TRULICITY is packaged in a cardboard outer carton containing 4 single-dose TRULICITY pens and is supplied as follows:
| Total Strength per Total Volume | NDC |
|---|---|
| 0.75 mg/0.5 mL | NDC 0002-1433-80 |
| 1.5 mg/0.5 mL | NDC 0002-1434-80 |
| 3 mg/0.5 mL | NDC 0002-2236-80 |
| 4.5 mg/0.5 mL | NDC 0002-3182-80 |
Storage and Handling
- Store TRULICITY in the refrigerator at 36°F to 46°F (2°C to 8°C).
- If needed, each single-dose pen can be kept at room temperature, not to exceed 86°F (30°C) for a total of 14 days.
- Do not freeze TRULICITY. Do not use TRULICITY if it has been frozen.
- Protect TRULICITY from light. Storage of TRULICITY in the original carton is recommended until time of administration.
Source: Trulicity prescribing information (FDA label on DailyMed), revised 2026-06-16
Trulicity dosing: common questions
What should you expect in the first week of Trulicity?
From its FDA label: The recommended starting dosage of TRULICITY is 0.75 mg injected subcutaneously once weekly. Your clinician may adjust this.
Can you skip a week of Trulicity?
Its FDA label covers a missed dose, not a planned break, so ask your prescriber before skipping one on purpose. On a missed dose it says: If a dose is missed, instruct patients to administer the dose as soon as possible if there are at least 3 days (72 hours) until the next scheduled dose.
What is the starting dose of Trulicity?
The recommended starting dosage of TRULICITY is 0.75 mg injected subcutaneously once weekly.
What is the maximum or maintenance dose of Trulicity?
The maximum recommended dosage is 4.5 mg injected subcutaneously once weekly.
What if you miss a dose of Trulicity?
If a dose is missed, instruct patients to administer the dose as soon as possible if there are at least 3 days (72 hours) until the next scheduled dose.
How long can Trulicity stay out of the fridge?
If needed, each single-dose pen can be kept at room temperature, not to exceed 86°F (30°C) for a total of 14 days.
Where do you inject Trulicity?
Inject TRULICITY subcutaneously in the abdomen, thigh, or upper arm.
When should you take Trulicity?
Administer TRULICITY once weekly, any time of day, with or without food.
How do you use Trulicity?
From its FDA-approved Medication Guide: Read the Instructions for Use that comes with TRULICITY. Use TRULICITY exactly as your healthcare provider tells you to. Your healthcare provider should show you how to use TRULICITY before you use it for the first time. Inject TRULICITY under the skin (subcutaneously) of your stomach (abdomen), thigh, or upper arm. Do not inject TRULICITY into a muscle (intramuscularly) or vein (intravenously). Use TRULICITY 1 time each week on the same day each week at any time of the day. You may change the day of the week as long as your last dose was given 3 or more days before. If you miss a dose of TRULICITY, take the missed dose as soon as possible if there are at least 3 days (72 hours) until your next scheduled dose. If there are less than 3 days remaining, skip the missed dose and take your next dose on the regularly scheduled day. Do not take 2 doses of TRULICITY within 3 days of each other. TRULICITY may be taken with or without food. Do not mix insulin and TRULICITY together in the same injection.
Dosing is decided by your clinician. This is the label's text for reference, not instructions for you.