From FDA labels and trial registries

How long does a GLP-1 take to work?

The dose steps up first, over weeks or months, and weight loss then builds for most of a year or more. On semaglutide 2.4 mg, people had lost 10.6% at week 20 and 15.6% at week 68. On tirzepatide, 20.9% at week 36 and 22.5% at week 72. After that it holds rather than grows: 15.9% at two years and 22.9% at week 176.

Schedules and half-lives from each manufacturer's FDA label on DailyMed, read every day; newest revision here Aug 28, 2026. Weight figures from 55 trials' posted results on ClinicalTrials.gov.

Why these can differ from other pages: a trial's registry entry and its headline use different analyses. The headline in the paper or label also accounts for people who stopped or were missing: 14.9% for STEP 1 and 20.9% for SURMOUNT-1, against 15.6% and 22.5% posted to the registry.

From each FDA label

How long each medicine takes to reach its dose, and how long it stays

The soonest each label's schedule allows. A prescriber can go slower: the Wegovy and Saxenda labels say to consider delaying a step that is not tolerated. The half-life is how long half of a dose takes to leave the body.

BrandFirst dose meant to treatTop dose, at the soonestHalf-lifeStays in the body
Foundayo5.5 mg from day 6117.2 mg from day 151approximately 29 to 49 hoursabout 6 to 10 days (our arithmetic)
Mounjaro5 mg from week 5 if needed15 mg from week 21approximately 5 daysabout 25 days (our arithmetic)
OzempicInjection0.5 mg from week 52 mg from week 13approximately 1 weekabout 5 weeks
Rybelsus and Ozempic tabletsRybelsus7 mg from day 3114 mg from day 61approximately one weekabout five weeks
Rybelsus and Ozempic tabletsOzempic tablets4 mg from day 319 mg from day 61
Saxenda3 mg from week 5Same doseapproximately 13 hoursabout 3 days (our arithmetic)
Trulicity1.5 mg from week 5 if needed4.5 mg from week 13approximately 5 daysabout 25 days (our arithmetic)
Victoza1.2 mg from week 21.8 mg from week 3approximately 13 hoursabout 3 days (our arithmetic)
WegovyInjection2.4 mg from week 177.2 mg from week 21approximately 1 weekabout 5 to 7 weeks
WegovyTablet25 mg from day 91Same dose
Zepbound5 mg from week 515 mg from week 21approximately 5-6 daysabout 25 to 30 days (our arithmetic)

Where a label states how long the medicine stays, that is its figure. Where it does not, we show five half-lives, the usual rule for when almost all of a dose has left.

Every registered trial

Weight change by week of treatment

Each dot is one trial's average at its top dose, in people without diabetes, on the same axes. A dot further right is a longer trial, not the same people measured again, except where a trial has two.

MedicinePlacebo in the same trial

Tirzepatide15 mg or highest tolerated dose
0-5%-10%-15%-20%-25%StartWk 52Wk 104Wk 156SURMOUNT-OSA placebo: -1.56% at week 52NCT04847557 placebo: -2.24% at week 52SURMOUNT-J placebo: -1.7% at week 72SURMOUNT-1 placebo: -2.4% at week 72SURMOUNT-1 placebo: -2.1% at week 176SURMOUNT-4 lead-in: -20.9% at week 36SURMOUNT-OSA: -17.65% at week 52NCT04847557: -13.85% at week 52SURMOUNT-J: -22.7% at week 72SURMOUNT-5: -20.2% at week 72SURMOUNT-1: -22.5% at week 72SURMOUNT-1: -22.9% at week 176-22.9%
Semaglutide injection2.4 mg and 7.2 mg
0-5%-10%-15%-20%-25%StartWk 52Wk 104Wk 156STEP12 placebo: -2.2% at week 44STEP 10 placebo: -2.7% at week 52STEP-HFpEF placebo: -2.5% at week 52NCT05064735 placebo: -2.5% at week 68STEP 1 placebo: -2.8% at week 68STEP 6 placebo: -1.9% at week 68STEP 3 placebo: -5.8% at week 68STEP UP placebo: -3.8% at week 72STEP 5 placebo: -1.9% at week 104STEP 4 lead-in: -10.6% at week 20STEP12: -12.2% at week 44STEP 10: -14.4% at week 52STEP-HFpEF: -13.9% at week 52NCT05064735: -14.2% at week 68STEP 1: -15.6% at week 68STEP 8: -16.4% at week 68STEP 6: -13.4% at week 68STEP 3: -16.5% at week 68STEP UP: -19.5% at week 72STEP UP: -16.4% at week 72SURMOUNT-5: -13.7% at week 72STEP 5: -15.9% at week 104-19.5%
Semaglutide tablets25 mg and 50 mg
0-5%-10%-15%-20%-25%StartWk 52Wk 104Wk 156OASIS 4 placebo: -2.5% at week 64OASIS 1 placebo: -2.2% at week 68OASIS 2 placebo: -1.5% at week 68OASIS 4: -14.4% at week 64OASIS 1: -15.8% at week 68OASIS 2: -14.9% at week 68-15.8%
Orforglipron36 mg in the trials, sold as Foundayo
0-5%-10%-15%-20%-25%StartWk 52Wk 104Wk 156ATTAIN-J placebo: -0.63% at week 72ATTAIN-1 placebo: -0.87% at week 72ATTAIN-J: -7.93% at week 72ATTAIN-1: -12.35% at week 72-12.35%
Liraglutide3 mg
0-5%-10%-15%-20%-25%StartWk 52Wk 104Wk 156NCT03038620 placebo: +1.19% at week 40SCALE IBT placebo: -4% at week 56NCT03038620: +6.59% at week 40SCALE IBT: -7.4% at week 56STEP 8: -6.4% at week 68-7.4%

What the longest trials add: semaglutide 2.4 mg stood at -15.6% at week 68 in STEP 1 and -15.9% at week 104 in STEP 5. Tirzepatide 15 mg stood at -22.5% at week 72 and -22.9% at week 176 in SURMOUNT-1, the week 176 figure counting only people who started with prediabetes.

Every result: 129 arms in 55 trials, including people with diabetes and every dose
Medicine and doseTrialWhoWeekWeight changePlacebo
Dulaglutide, 0.75 mgPIONEER 10Includes diabetes26+0.25%None
Dulaglutide, 0.75 mgPIONEER 10Includes diabetes52+1.25%None
Dulaglutide, 1.5 mgSURPASS-CVOTIncludes diabetes156-4.82%None
Liraglutide, 1.8 mgPIONEER 4Includes diabetes26-3.33%-0.6%
Liraglutide, 0.9 mgPIONEER 9Includes diabetes26+0.08%-1.58%
Liraglutide, 3 mgNCT03038620Without diabetes40+6.59%+1.19%
Liraglutide, 1.8 mgPIONEER 4Includes diabetes52-3.25%-0.99%
Liraglutide, 0.9 mgPIONEER 9Includes diabetes52+0.68%-1.42%
Liraglutide, 3 mgNCT01272219Includes diabetes56-7.98%-2.62%
Liraglutide, 3 mgSCALE IBTWithout diabetes56-7.4%-4%
Liraglutide, 3 mgSCALE InsulinIncludes diabetes56-6%-1.5%
Liraglutide, 3 mgNCT01272232Includes diabetes56-5.9%-2%
Liraglutide, 1.8 mgNCT01272232Includes diabetes56-4.6%-2%
Liraglutide, 3 mgNCT01272219Includes diabetes68-8.44%-6.77%
Liraglutide, 3 mgSTEP 8Without diabetes68-6.4%None
Liraglutide, 3 mgNCT01272232Includes diabetes68-4.7%-2.7%
Liraglutide, 1.8 mgNCT01272232Includes diabetes68-3.6%-2.7%
Liraglutide, 3 mgNCT01272219Includes diabetes160-6.14%-1.89%
Orforglipron, 36 mgACHIEVE-1Includes diabetes40-7.9%-1.6%
Orforglipron, 36 mgACHIEVE-2Includes diabetes40-7.3%None
Orforglipron, 12 mgACHIEVE-2Includes diabetes40-6.3%None
Orforglipron, 36 mgACHIEVE-5Includes diabetes40-6.1%+0.6%
Orforglipron, 12 mgACHIEVE-1Includes diabetes40-6.1%-1.6%
Orforglipron, 12 mgACHIEVE-5Includes diabetes40-5.8%+0.6%
Orforglipron, 3 mgACHIEVE-1Includes diabetes40-4.7%-1.6%
Orforglipron, 3 mgACHIEVE-2Includes diabetes40-3.5%None
Orforglipron, 3 mgACHIEVE-5Includes diabetes40-2.7%+0.6%
Orforglipron, 36 mgACHIEVE-3Includes diabetes52-9.2%None
Orforglipron, 12 mgACHIEVE-3Includes diabetes52-6.7%None
Orforglipron, 36 mgATTAIN-1Without diabetes72-12.35%-0.87%
Orforglipron, 36 mgATTAIN-2Includes diabetes72-10.54%-2.21%
Orforglipron, 12 mgATTAIN-1Without diabetes72-9.27%-0.87%
Orforglipron, 12 mgATTAIN-JWithout diabetes72-8.69%-0.63%
Orforglipron, 36 mgATTAIN-JWithout diabetes72-7.93%-0.63%
Orforglipron, 6 mgATTAIN-1Without diabetes72-7.82%-0.87%
Orforglipron, 12 mgATTAIN-2Includes diabetes72-7.78%-2.21%
Orforglipron, 6 mgATTAIN-JWithout diabetes72-5.9%-0.63%
Orforglipron, 6 mgATTAIN-2Includes diabetes72-5.5%-2.21%
SemaglutideNCT04944992Without diabetes24-7.1%None
Semaglutide, 1 mgSUSTAIN 9Includes diabetes30-5.4%-1%
SemaglutideNCT04998136Without diabetes44-16.4%-2.6%
Semaglutide, 2.4 mgSTEP7Includes diabetes44-12.5%-3.6%
Semaglutide, 2.4 mgSTEP12Without diabetes44-12.2%-2.2%
Semaglutide, 2.4 mgSTEP 10Without diabetes52-14.4%-2.7%
Semaglutide, 2.4 mgSTEP-HFpEFWithout diabetes52-13.9%-2.5%
Semaglutide, 2.4 mgSTEP HFpEF DMIncludes diabetes52-10.2%-3.2%
Semaglutide, 2.4 mgBARI-STEPIncludes diabetes68-18%+0.4%
Semaglutide, 2.4 mgSTEP 3Without diabetes68-16.5%-5.8%
Semaglutide, 2.4 mgSTEP 8Without diabetes68-16.4%None
Semaglutide, 2.4 mgSTEP 1Without diabetes68-15.6%-2.8%
Semaglutide, 2.4 mgNCT05064735Without diabetes68-14.2%-2.5%
Semaglutide, 2.4 mgSTEP 6Without diabetes68-13.4%-1.9%
Semaglutide, 2.4 mgSTEP 2Includes diabetes68-9.9%-3.3%
Semaglutide, 1.7 mgSTEP 6Without diabetes68-9.9%-1.9%
Semaglutide, 2.4 mgSTEP 4Without diabetes, after a lead-in68-8.3%+6.5%
Semaglutide, 1 mgSTEP 2Includes diabetes68-7.2%None
Semaglutide, 7.2 mgSTEP UPWithout diabetes72-19.5%-3.8%
Semaglutide, 2.4 mgSTEP UPWithout diabetes72-16.4%None
Semaglutide, 2.4 mgSURMOUNT-5Without diabetes72-13.7%None
Semaglutide, 7.2 mgNCT05649137Includes diabetes72-13.5%-4%
Semaglutide, 2.4 mgNCT05649137Includes diabetes72-10.7%-4%
Semaglutide, 2.4 mgSTEP 5Without diabetes104-15.9%-1.9%
Semaglutide tablets, 14 mgPIONEER 12Includes diabetes26-5%None
Semaglutide tablets, 14 mgPIONEER 4Includes diabetes26-4.89%-0.6%
Semaglutide tablets, 14 mgPIONEER 1Includes diabetes26-4.71%-1.37%
Semaglutide tablets, 14 mgPIONEER 8Includes diabetes26-4.3%-0.47%
Semaglutide tablets, 14 mgPIONEER 11Includes diabetes26-4%-1%
Semaglutide tablets, 7 mgPIONEER 12Includes diabetes26-4%None
Semaglutide tablets, 14 mgPIONEER 5Includes diabetes26-3.75%-0.92%
Semaglutide tablets, 14 mgPIONEER 9Includes diabetes26-3.54%-1.58%
Semaglutide tablets, 14 mgPIONEER 3Includes diabetes26-3.44%None
Semaglutide tablets, 14 mgPIONEER 10Includes diabetes26-3.21%None
Semaglutide tablets, 7 mgPIONEER 8Includes diabetes26-3.11%-0.47%
Semaglutide tablets, 7 mgPIONEER 11Includes diabetes26-3%-1%
Semaglutide tablets, 7 mgPIONEER 1Includes diabetes26-2.85%-1.37%
Semaglutide tablets, 7 mgPIONEER 3Includes diabetes26-2.36%None
Semaglutide tablets, 3 mgPIONEER 12Includes diabetes26-2%None
Semaglutide tablets, 3 mgPIONEER 8Includes diabetes26-1.73%-0.47%
Semaglutide tablets, 3 mgPIONEER 1Includes diabetes26-1.67%-1.37%
Semaglutide tablets, 7 mgPIONEER 9Includes diabetes26-1.63%-1.58%
Semaglutide tablets, 7 mgPIONEER 10Includes diabetes26-1.49%None
Semaglutide tablets, 3 mgPIONEER 3Includes diabetes26-1.23%None
Semaglutide tablets, 3 mgPIONEER 11Includes diabetes26-1%-1%
Semaglutide tablets, 3 mgPIONEER 9Includes diabetes26-0.64%-1.58%
Semaglutide tablets, 3 mgPIONEER 10Includes diabetes26-0.28%None
Semaglutide tablets, 50 mgPIONEER PLUSIncludes diabetes52-8.5%None
Semaglutide tablets, 25 mgPIONEER PLUSIncludes diabetes52-7.3%None
Semaglutide tablets, 14 mgACHIEVE-3Includes diabetes52-5.3%None
Semaglutide tablets, 14 mgPIONEER 4Includes diabetes52-4.94%-0.99%
Semaglutide tablets, 14 mgPIONEER PLUSIncludes diabetes52-4.7%None
Semaglutide tablets, 14 mgPIONEER 8Includes diabetes52-4.42%+0.65%
Semaglutide tablets, 14 mgPIONEER 9Includes diabetes52-4.42%-1.42%
Semaglutide tablets, 14 mgPIONEER 3Includes diabetes52-3.83%None
Semaglutide tablets, 7 mgACHIEVE-3Includes diabetes52-3.7%None
Semaglutide tabletsPIONEER 7Includes diabetes52-2.99%None
Semaglutide tablets, 7 mgPIONEER 3Includes diabetes52-2.63%None
Semaglutide tablets, 7 mgPIONEER 8Includes diabetes52-2.54%+0.65%
Semaglutide tablets, 14 mgPIONEER 10Includes diabetes52-2.33%None
Semaglutide tablets, 3 mgPIONEER 3Includes diabetes52-1.65%None
Semaglutide tablets, 7 mgPIONEER 10Includes diabetes52-1.34%None
Semaglutide tablets, 7 mgPIONEER 9Includes diabetes52-1.23%-1.42%
Semaglutide tablets, 3 mgPIONEER 8Includes diabetes52-1.18%+0.65%
Semaglutide tablets, 3 mgPIONEER 9Includes diabetes52-0.03%-1.42%
Semaglutide tablets, 3 mgPIONEER 10Includes diabetes52-0.02%None
Semaglutide tablets, 25 mgOASIS 4Without diabetes64-14.4%-2.5%
Semaglutide tablets, 50 mgOASIS 1Without diabetes68-15.8%-2.2%
Semaglutide tablets, 50 mgOASIS 2Without diabetes68-14.9%-1.5%
Semaglutide tablets, 14 mgPIONEER 3Includes diabetes78-3.47%None
Semaglutide tablets, 7 mgPIONEER 3Includes diabetes78-2.92%None
Semaglutide tablets, 3 mgPIONEER 3Includes diabetes78-1.87%None
Tirzepatide, 15 mgSURMOUNT-CNIncludes diabetes52-19.9%-2.4%
Tirzepatide, highest tolerated doseSURMOUNT-OSAWithout diabetes52-17.65%-1.56%
Tirzepatide, 10 mgSURMOUNT-CNIncludes diabetes52-14.4%-2.4%
Tirzepatide, highest tolerated doseNCT04847557Without diabetes52-13.85%-2.24%
Tirzepatide, highest tolerated doseSURMOUNT-4Without diabetes, after a lead-in64-6%+9.9%
Tirzepatide, 15 mgSURMOUNT-JWithout diabetes72-22.7%-1.7%
Tirzepatide, 15 mgSURMOUNT-1Without diabetes72-22.5%-2.4%
Tirzepatide, 10 mgSURMOUNT-1Without diabetes72-21.4%-2.4%
TirzepatideSURMOUNT-3Without diabetes72-21.1%+3.3%
Tirzepatide, 15 mgSURMOUNT-5Without diabetes72-20.2%None
Tirzepatide, 10 mgSURMOUNT-JWithout diabetes72-17.8%-1.7%
Tirzepatide, 5 mgSURMOUNT-1Without diabetes72-16%-2.4%
Tirzepatide, 15 mgSURMOUNT-2Includes diabetes72-15.7%-3.3%
Tirzepatide, 10 mgSURMOUNT-2Includes diabetes72-13.4%-3.3%
Tirzepatide, highest tolerated doseSURMOUNT-4Without diabetes, after a lead-in88-6.7%+14.8%
Tirzepatide, highest tolerated doseSURPASS-CVOTIncludes diabetes156-11.6%None
Tirzepatide, 15 mgSURMOUNT-1Without diabetes176-22.9%-2.1%
Tirzepatide, 10 mgSURMOUNT-1Without diabetes176-19.9%-2.1%
Tirzepatide, 5 mgSURMOUNT-1Without diabetes176-15.4%-2.1%

Figures are as each trial posted them on ClinicalTrials.gov, the first analysis where it posts more than one, and the trials differ in who they enrolled, so they are not a head-to-head comparison. The two lead-in figures come from the papers of STEP 4 and SURMOUNT-4.

When it levels off

When weight loss reaches a plateau

The clearest evidence is a post hoc analysis of Lilly's SURMOUNT-1 and SURMOUNT-4 trials. Among adherent people who lost at least 5%, the median time to a plateau in SURMOUNT-1 was 24.3 weeks with overweight, 26.0 weeks with class I obesity and 36.1 weeks with class II or III. By week 72, between 87.6% and 90.2% had plateaued. People on higher doses, younger people and women reached it later. The study counted a plateau as a change of under 5% over 12 weeks and every 12 weeks after, so weight can still drift slowly during one.

If it does not seem to work

Not everyone responds the same

A mean hides the spread. In STEP 1, 86.4% of people measured on semaglutide 2.4 mg lost at least 5% of their weight (1,047 of 1,212), against 31.5% on placebo. In SURMOUNT-1, 96.3% of people on tirzepatide 15 mg did, as the trial posted it. They enrolled different people and are not a head-to-head comparison.

Saxenda's label sets a point to judge it: “Evaluate the change in body weight 16 weeks after initiating SAXENDA and discontinue SAXENDA if the patient has not lost at least 4% of baseline body weight, since it is unlikely that the patient will achieve and sustain clinically meaningful weight loss with continued treatment.”

From each FDA label

How long the side effects last

What each label says about when stomach side effects happen. Where a label is not listed here, it makes no such statement.

  • Foundayo: “The incidence of nausea, vomiting, and diarrhea was higher during the FOUNDAYO dosage escalation period and decreased over time.”
  • Mounjaro: “The majority of reports of nausea, vomiting, and/or diarrhea occurred during dose escalation and decreased over time.”
  • Ozempic: “The majority of reports of nausea, vomiting, and/or diarrhea occurred during dose escalation.”
  • Rybelsus and Ozempic tablets: “The majority of reports of nausea, vomiting and/or diarrhea occurred during dose escalation.”
  • Zepbound: “The majority of nausea, vomiting, and/or diarrhea events occurred during dose escalation and decreased over time.”
If you stop

How quickly weight returns

Two trials gave everyone the medicine first, then switched half to placebo. In SURMOUNT-4, by week 64, people who stayed on it had changed -6% from that switch and people on placebo +9.9%. In STEP 4, by week 68, people who stayed on it had changed -8.3% from that switch and people on placebo +6.5%. In SURMOUNT-4, by week 88, people who stayed on it had changed -6.7% from that switch and people on placebo +14.8%. What happens when you stop a GLP-1

Questions

How long: common questions

How long does a GLP-1 take to work?

The dose steps up over weeks or months first, then weight loss builds for most of a year or more. On semaglutide 2.4 mg, people had lost 10.6% by week 20 in STEP 4's lead-in and 15.6% by week 68 in STEP 1, as the registry posts it. On tirzepatide, 20.9% by week 36 in SURMOUNT-4's lead-in and 22.5% at 15 mg by week 72 in SURMOUNT-1. These are trial averages, not a prediction for one person.

When does GLP-1 weight loss stop or plateau?

In SURMOUNT-1, among adherent people who lost at least 5%, the median time to a plateau was 24.3 weeks with overweight and 36.1 weeks with the highest BMI, and about 88 to 90% had plateaued by week 72, by that study's definition of a plateau. Semaglutide's two-year trial shows the same shape: 15.6% at week 68 in STEP 1 and 15.9% at week 104 in STEP 5.

How much weight can you lose in a month on a GLP-1?

Trials report averages over many months, not per month. By our arithmetic, the 10.6% at week 20 on semaglutide and the 20.9% at week 36 on tirzepatide each come to about 2 to 2.5% of body weight a month, while the dose was rising, and it slows as a person nears a plateau. Those are averages across many people, and individuals vary widely.

What if a GLP-1 is not working for me?

It does not work the same for everyone. In STEP 1, 86.4% of people measured on semaglutide 2.4 mg lost at least 5%, so about 14 in 100 did not. In SURMOUNT-1, 96.3% on tirzepatide 15 mg did. The trials differ, so these are not a head-to-head comparison. Weight levelling off after months is expected and is not the same as the medicine failing. Ask your prescriber: the dose may have further to go, or another medicine may suit you better.

How long do GLP-1 side effects last?

Most labels tie nausea, vomiting and diarrhea to the weeks the dose is going up. The labels of Zepbound and Mounjaro also say these decreased over time. Each label's own sentence is on this page.

How long does Foundayo stay in your system?

Foundayo's FDA label gives a half-life of approximately 29 to 49 hours and no figure for how long it stays. By the usual rule of five half-lives, that is about 6 to 10 days, which is our arithmetic and not the label's.

How long does Mounjaro stay in your system?

Mounjaro's FDA label gives a half-life of approximately 5 days and no figure for how long it stays. By the usual rule of five half-lives, that is about 25 days, which is our arithmetic and not the label's.

How long does Ozempic stay in your system?

Ozempic's FDA label says: With an elimination half-life of approximately 1 week, semaglutide will be present in the circulation for about 5 weeks after the last dose.

How long does Rybelsus and Ozempic tablets stay in your system?

Rybelsus and Ozempic tablets's FDA label says: Semaglutide is present in the circulation for about five weeks after the last semaglutide tablet dose.

How long does Saxenda stay in your system?

Saxenda's FDA label gives a half-life of approximately 13 hours and no figure for how long it stays. By the usual rule of five half-lives, that is about 3 days, which is our arithmetic and not the label's.

How long does Trulicity stay in your system?

Trulicity's FDA label gives a half-life of approximately 5 days and no figure for how long it stays. By the usual rule of five half-lives, that is about 25 days, which is our arithmetic and not the label's.

How long does Victoza stay in your system?

Victoza's FDA label gives a half-life of approximately 13 hours and no figure for how long it stays. By the usual rule of five half-lives, that is about 3 days, which is our arithmetic and not the label's.

How long does Wegovy stay in your system?

Wegovy's FDA label says: With an elimination half-life of approximately 1 week, semaglutide will be present in the circulation for about 5 to 7 weeks after the last injectable dose of 2.4 mg or 7.2 mg or oral dose of 25 mg.

How long does Zepbound stay in your system?

Zepbound's FDA label gives a half-life of approximately 5-6 days and no figure for how long it stays. By the usual rule of five half-lives, that is about 25 to 30 days, which is our arithmetic and not the label's.

Averages from trials. How long a medicine takes for you is a question for your prescriber.

GLPcompare is an informational data platform, not a medical provider or pharmacy. Nothing here is medical advice, a diagnosis, or a recommendation to start, stop, or change any treatment. Data is aggregated from public sources and can be incomplete or out of date. Always confirm with a licensed clinician and the current FDA label.