NCT01832532 trial results

Inclusion Criteria: * Age 18-60 years * Diagnosis of severe obstructive sleep apnea (OSA) AHI ≥ 8 /hour of sleep * Ability and willingness to comply with all protocol procedures e.g. correct handling of trial product, compliance to visit schedule * BMI of ≥ 27 * For Cohort 1: If female of childbearing capacity, willing to use acceptable birth control during use of study drug Exclusion Criteria: * A major medical condition such as renal or hepatic failure * Treatment with glucagon-like peptide-1 (GLP-1) receptor agonists, dipeptidyl peptidase-4 inhibitors or insulin within the last 3 months prior to screening * Diagnosis of type 1 or type 2 diabetes per judgment of the investigator * BMI \< 27 * History of glycosylated hemoglobin (HbA1c) equal to or above 6.5% * Significant craniofacial abnormalities that may cause OSA * Respiratory and neuromuscular diseases that could interfere with the results of the trial in the opinion of the investigator * Use of central stimulants, hypnotics, mirtazepine, opioids, trazodone or drugs in the incretin family within the previous 3 months prior to screening * Previous surgical treatment for obesity * Familial or personal history of Multiple Endocrine Neoplasia type 2 or familial Medullary Thyroid Carcinoma * Personal or immediate family history of thyroid cancer * History of chronic pancreatitis or idiopathic acute pancreatitis * History of Major Depressive Disorder or suicide attempts * Systolic blood pressure equal to or above 160 mmHg and/or diastolic blood pressure equal to or above 100 mmHg * History of alcoholism * Pregnancy or breastfeeding