NCT03961256 trial results

Inclusion criteria: * Recipients of solitary kidney transplants (i.e. not combined liver-kidney, pancreas-kidney etc.) * At 4 months after transplantation: Prediabetes (fasting blood glucose 100-125 mg/dl; or 2 hr glucose 140-199 or HgbA1c 5.7-6.4%) Exclusion criteria: * Diabetes pre-transplantation * Diabetes at 4 months * \<18 years of age * eGFR \<30 ml/min (estimated by MDRD equation from serum creatinine) * Active acute cellular rejection including borderline (If treated and resolved, these patients can be included) * BK nephropathy active * History of pancreatitis, pre-existing moderate-to-severe gastroparesis, liver cirrhosis or family /personal history of multiple endocrine neoplasia 2 or medullary thyroid cancer * Pregnant or breastfeeding women. Female Subject must be either: * Of non-child bearing potential: Post-menopausal (defined as at least 1 year without any menses) prior to screening , or documented surgically sterile or status post-hysterectomy * Or if childbearing potential, agree not to try and become pregnant during the study for at least 90 days after the final study drug administration. And have a negative serum or urine pregnancy test. And if heterosexually active, agree to consistently use two forms of highly effective birth control. * Hypersensitivity to Exenatide