Drug class

The Small-molecule GLP-1 class

Small-molecule GLP-1 medications, with sourced prices, shortage reports and study results.

Last checked · Oct 3, 2026 UTC

1approved

1in development

Approved in this class

Alphabetical by active ingredient. Approved uses depend on the specific brand and formulation.

Small-molecule GLP-1

Orforglipron

Foundayo

Oral tablet (any time of day, no food or water restriction) · Once daily

FDA shortage report

Published entry quote

from $149/mo

Foundayo (LillyDirect self-pay) · LillyDirect (Eli Lilly)

Checked Sep 30, 2026

Price conditions

self-pay cash, lowest dose; ~$25/mo with commercial coverage

The first oral small-molecule GLP-1 pill for weight loss; FDA-approved April 2026. LillyDirect self-pay ladder: $149 (0.8 mg), $199 (2.5 mg), $299 (5.5 and 9 mg), $299 (14.5 and 17.2 mg with a 45-day refill, else $349); the 2.5 mg and 5.5 mg doses are temporarily $149 and $199 through Dec 31, 2026.

30-day supply

Checked Sep 30, 2026. Entry quotes are not estimates of ongoing treatment cost.

Prices, evidence & safety

Investigational (pipeline)

Alphabetical by active ingredient. These entries are not FDA-approved for this category; open a record for the studied uses and evidence.

Small-molecule GLP-1Phase 3

Aleniglipron

Aleniglipron (investigational)

Oral tablet · Once daily

Investigational. No FDA-approved purchase option.

Study evidence & development

GLPcompare is an informational data platform, not a medical provider or pharmacy. Nothing here is medical advice, a diagnosis, or a recommendation to start, stop, or change any treatment. Data is aggregated from public sources and can be incomplete or out of date. Always confirm with a licensed clinician and the current FDA label.