From the FDA label

How to use Trulicity

Trulicity's FDA-approved Instructions for Use cover 4 products: 0.75 mg single-dose pen; 1.5 mg single-dose pen; 3 mg single-dose pen; 4.5 mg single-dose pen. Each is below in the label's own words. Talk to your healthcare provider about how to inject it the right way.

The label's pictures are in the original: FDA label on DailyMed (Eli Lilly and Company), revised , version 62. Read every day: a new FDA version updates this page by itself.

Instructions for Use

Trulicity: 0.75 mg single-dose pen

Every step, in the label's own words
  • Instructions for Use
  • Trulicity (TRU-li-si-tee) (dulaglutide) injection, for subcutaneous use 0.75 mg/0.5 mL Single-Dose Pen use 1 time each week (once weekly)
  • Information About Trulicity Single-Dose Pen Please read this Instructions for Use and the Medication Guide carefully and completely before using your Trulicity Single-Dose Pen. Talk to your healthcare provider about how to inject Trulicity the right way. Trulicity Single-Dose Pen (Pen) is a disposable, prefilled medicine delivery device. Each Pen contains 1 dose of Trulicity (0.75 mg/0.5 mL). Each Pen should only be used 1 time. Trulicity is used 1 time each week. You may want to mark your calendar to remind you when to take your next dose.
  • Before You Get Started
  • Remove Check Inspect Prepare
  • Remove the Pen from the refrigerator. Leave the Base Cap on until you are ready to inject. Check the Pen label to make sure you have the right medicine and it has not expired. Check the Pen to make sure that it is not damaged and inspect the medicine to make sure it is not cloudy, discolored or has particles in it. Wash your hands.
  • Choose Your Injection Site
  • Your healthcare provider can help you choose the injection site that is best for you.
  • Change (rotate) your injection site each week. You may use the same area of your body, but be sure to choose a different injection site in that area. You may inject the medicine into your stomach (abdomen) or thigh.
  • Another person should give you the injection in the back of your upper arm.
  • Step 1 Uncap the Pen Make sure the Pen is locked. Pull the Base Cap straight off and throw it away in your household trash. Do not put the Base Cap back on — this could damage the needle. Do not touch the needle.
  • Step 2 Place and Unlock Place the Clear Base flat and firmly against your skin at the injection site. Unlock by turning the Lock Ring.
  • Step 3 Press and Hold Press and hold the green Injection Button. You will hear a loud click. Continue holding the Clear Base firmly against your skin until you hear a second click. This happens when the needle starts retracting in about 5-10 seconds. Remove the Pen from your skin. You will know your injection is complete when the gray plunger is visible.
  • Important Information Disposal of Pen Storage and Handling Commonly Asked Questions Other Information Where to Learn More
  • Disposing of Your Used Pens Put your used Pens in a FDA-cleared sharps disposal container right away after use. Do not throw away (dispose of) Pens in your household trash. If you do not have a FDA-cleared sharps disposal container, you may use a household container that is: - made of a heavy-duty plastic, - can be closed with a tight-fitting, puncture-resistant lid, without sharps being able to come out, - upright and stable during use, - leak-resistant, and - properly labeled to warn of hazardous waste inside the container. When your sharps disposal container is almost full, you will need to follow your community guidelines for the right way to dispose of your sharps disposal container. There may be state or local laws about how you should throw away used needles and syringes. For more information about safe sharps disposal, and for specific information about sharps disposal in the state that you live in, go to the FDA's website at: http://www.fda.gov/safesharpsdisposal. Do not recycle your used sharps disposal container.
  • Storage and Handling
  • Store your Pen in the refrigerator between 36°F to 46°F (2°C to 8°C). You may store your Pen at room temperature below 86°F (30°C) for up to a total of 14 days. Do not freeze your Pen. If the Pen has been frozen, throw the Pen away and use a new Pen. Storage of your Pen in the original carton is recommended. Protect your Pen from direct heat and light. The Pen has glass parts. Handle it carefully. If you drop it on a hard surface, do not use it. Use a new Pen for your injection. Keep your Trulicity Pen and all medicines out of the reach of children.
  • Commonly Asked Questions
  • What if I see air bubbles in my Pen? Air bubbles are normal. What if I unlock the Pen and press the green Injection Button before pulling off the Base Cap? Do not remove the Base Cap. Throw away the Pen and get a new Pen. What if there is a drop of liquid on the tip of the needle when I remove the Base Cap? A drop of liquid on the tip of the needle is normal. Do I need to hold the Injection Button down until the injection is complete? This is not necessary, but it may help you keep the Pen steady and firm against your skin. I heard more than 2 clicks during my injection—2 louder clicks and 1 soft one. Did I get my complete injection? Some patients may hear a soft click right before the second loud click. That is the normal operation of the Pen. Do not remove the Pen from your skin until you hear the second louder click. What if there is a drop of liquid or blood on my skin after my injection? This is normal. I am not sure if my Pen worked the right way. Check to see if you have received your dose. Your dose was delivered the right way if the gray plunger is visible (see step 3). Also contact Lilly at 1-800-Lilly-Rx (1-800-545-5979) for further instructions. Until then, store your Pen safely to avoid an accidental needle stick.
  • Other Information
  • If you have vision problems, do not use your Pen without help from a person trained to use the Trulicity Pen.
  • Where to Learn More
  • If you have any questions or problems with your Trulicity Single-Dose Pen, contact Lilly at 1-800-Lilly-Rx (1-800-545-5979) or call your healthcare provider. For more information about Trulicity Single-Dose Pen, visit our website at: www.trulicity.com.
  • SCAN THIS CODE TO LAUNCH www.trulicity.com
Instructions for Use

Trulicity: 1.5 mg single-dose pen

Every step, in the label's own words
  • Instructions for Use
  • Trulicity (TRU-li-si-tee) (dulaglutide) injection, for subcutaneous use 1.5 mg/0.5 mL Single-Dose Pen use 1 time each week (once weekly)
  • Information About Trulicity Single-Dose Pen Please read this Instructions for Use and the Medication Guide carefully and completely before using your Trulicity Single-Dose Pen. Talk to your healthcare provider about how to inject Trulicity the right way. Trulicity Single-Dose Pen (Pen) is a disposable, prefilled medicine delivery device. Each Pen contains 1 dose of Trulicity (1.5 mg/0.5 mL). Each Pen should only be used 1 time. Trulicity is used 1 time each week. You may want to mark your calendar to remind you when to take your next dose.
  • Before You Get Started
  • Remove Check Inspect Prepare
  • Remove the Pen from the refrigerator. Leave the Base Cap on until you are ready to inject. Check the Pen label to make sure you have the right medicine and it has not expired. Check the Pen to make sure that it is not damaged and inspect the medicine to make sure it is not cloudy, discolored or has particles in it. Wash your hands.
  • Choose Your Injection Site
  • Your healthcare provider can help you choose the injection site that is best for you.
  • Change (rotate) your injection site each week. You may use the same area of your body, but be sure to choose a different injection site in that area. You may inject the medicine into your stomach (abdomen) or thigh.
  • Another person should give you the injection in the back of your upper arm.
  • Step 1 Uncap the Pen Make sure the Pen is locked. Pull the Base Cap straight off and throw it away in your household trash. Do not put the Base Cap back on — this could damage the needle. Do not touch the needle.
  • Step 2 Place and Unlock Place the Clear Base flat and firmly against your skin at the injection site. Unlock by turning the Lock Ring.
  • Step 3 Press and Hold Press and hold the green Injection Button. You will hear a loud click. Continue holding the Clear Base firmly against your skin until you hear a second click. This happens when the needle starts retracting in about 5-10 seconds. Remove the Pen from your skin. You will know your injection is complete when the gray plunger is visible.
  • Important Information Disposal of Pen Storage and Handling Commonly Asked Questions Other Information Where to Learn More
  • Disposing of Your Used Pens Put your used Pens in a FDA-cleared sharps disposal container right away after use. Do not throw away (dispose of) Pens in your household trash. If you do not have a FDA-cleared sharps disposal container, you may use a household container that is: - made of a heavy-duty plastic, - can be closed with a tight-fitting, puncture-resistant lid, without sharps being able to come out, - upright and stable during use, - leak-resistant, and - properly labeled to warn of hazardous waste inside the container. When your sharps disposal container is almost full, you will need to follow your community guidelines for the right way to dispose of your sharps disposal container. There may be state or local laws about how you should throw away used needles and syringes. For more information about safe sharps disposal, and for specific information about sharps disposal in the state that you live in, go to the FDA's website at: http://www.fda.gov/safesharpsdisposal. Do not recycle your used sharps disposal container.
  • Storage and Handling
  • Store your Pen in the refrigerator between 36°F to 46°F (2°C to 8°C). You may store your Pen at room temperature below 86°F (30°C) for up to a total of 14 days. Do not freeze your Pen. If the Pen has been frozen, throw the Pen away and use a new Pen. Storage of your Pen in the original carton is recommended. Protect your Pen from direct heat and light. The Pen has glass parts. Handle it carefully. If you drop it on a hard surface, do not use it. Use a new Pen for your injection. Keep your Trulicity Pen and all medicines out of the reach of children.
  • Commonly Asked Questions
  • What if I see air bubbles in my Pen? Air bubbles are normal. What if I unlock the Pen and press the green Injection Button before pulling off the Base Cap? Do not remove the Base Cap. Throw away the Pen and get a new Pen. What if there is a drop of liquid on the tip of the needle when I remove the Base Cap? A drop of liquid on the tip of the needle is normal. Do I need to hold the Injection Button down until the injection is complete? This is not necessary, but it may help you keep the Pen steady and firm against your skin. I heard more than 2 clicks during my injection—2 louder clicks and 1 soft one. Did I get my complete injection? Some patients may hear a soft click right before the second loud click. That is the normal operation of the Pen. Do not remove the Pen from your skin until you hear the second louder click. What if there is a drop of liquid or blood on my skin after my injection? This is normal. I am not sure if my Pen worked the right way. Check to see if you have received your dose. Your dose was delivered the right way if the gray plunger is visible (see step 3). Also contact Lilly at 1-800-Lilly-Rx (1-800-545-5979) for further instructions. Until then, store your Pen safely to avoid an accidental needle stick.
  • Other Information
  • If you have vision problems, do not use your Pen without help from a person trained to use the Trulicity Pen.
  • Where to Learn More
  • If you have any questions or problems with your Trulicity Single-Dose Pen, contact Lilly at 1-800-Lilly-Rx (1-800-545-5979) or call your healthcare provider. For more information about Trulicity Single-Dose Pen, visit our website at: www.trulicity.com.
  • SCAN THIS CODE TO LAUNCH www.trulicity.com
Instructions for Use

Trulicity: 3 mg single-dose pen

Every step, in the label's own words
  • Instructions for Use
  • Trulicity (TRU-li-si-tee) (dulaglutide) injection, for subcutaneous use 3 mg/0.5 mL Single-Dose Pen use 1 time each week (once weekly)
  • Information About Trulicity Single-Dose Pen
  • Please read this Instructions for Use and the Medication Guide carefully and completely before using your Trulicity Single-Dose Pen. Talk to your healthcare provider about how to inject Trulicity the right way.
  • Trulicity Single-Dose Pen (Pen) is a disposable, prefilled medicine delivery device. Each Pen contains 1 dose of Trulicity (3 mg/0.5 mL). Each Pen should only be used 1 time.
  • Trulicity is used 1 time each week. You may want to mark your calendar to remind you when to take your next dose.
  • Before You Get Started
  • Remove Check Inspect Prepare
  • Remove the Pen from the refrigerator. Leave the Base Cap on until you are ready to inject. Check the Pen label to make sure you have the right medicine and it has not expired. Expiration Date Check the Pen to make sure that it is not damaged and inspect the medicine to make sure it is not cloudy, discolored or has particles in it. Wash your hands.
  • Choose Your Injection Site
  • Your healthcare provider can help you choose the injection site that is best for you.
  • Change (rotate) your injection site each week. You may use the same area of your body, but be sure to choose a different injection site in that area. You may inject the medicine into your stomach (abdomen) or thigh.
  • Another person should give you the injection in the back of your upper arm.
  • Step 1 Uncap the Pen Make sure the Pen is locked. Pull the Base Cap straight off and throw it away in your household trash. Do not put the Base Cap back on — this could damage the needle. Do not touch the needle.
  • Step 2 Place and Unlock Place the Clear Base flat and firmly against your skin at the injection site. Unlock by turning the Lock Ring.
  • Step 3 Press and Hold Press and hold the green Injection Button. You will hear a loud click. Continue holding the Clear Base firmly against your skin until you hear a second click. This happens when the needle starts retracting in about 5-10 seconds. Remove the Pen from your skin.
  • Important Information
  • Disposal of Pen
  • Storage and Handling
  • Commonly Asked Questions
  • Other Information
  • Where to Learn More
  • Disposing of Your Used Pens Put your used Pens in a FDA-cleared sharps disposal container right away after use. Do not throw away (dispose of) Pens in your household trash. If you do not have a FDA-cleared sharps disposal container, you may use a household container that is: - made of a heavy-duty plastic, - can be closed with a tight-fitting, puncture-resistant lid, without sharps being able to come out, - upright and stable during use, - leak-resistant, and - properly labeled to warn of hazardous waste inside the container. When your sharps disposal container is almost full, you will need to follow your community guidelines for the right way to dispose of your sharps disposal container. There may be state or local laws about how you should throw away used needles and syringes. For more information about safe sharps disposal, and for specific information about sharps disposal in the state that you live in, go to the FDA's website at: http://www.fda.gov/safesharpsdisposal. Do not recycle your used sharps disposal container.
  • Store your Pen in the refrigerator between 36°F to 46°F (2°C to 8°C).
  • You may store your Pen at room temperature below 86°F (30°C) for a total of 14 days.
  • Do not freeze your Pen. If the Pen has been frozen, throw the Pen away and use a new Pen.
  • Storage of your Pen in the original carton is recommended. Protect your Pen from direct heat and light.
  • The Pen has glass parts. Handle it carefully. If you drop it on a hard surface, do not use it. Use a new Pen for your injection.
  • Keep your Trulicity Pen and all medicines out of the reach of children.
  • What if I see air bubbles in my Pen?
  • Air bubbles are normal.
  • What if I unlock the Pen and press the green Injection Button before pulling off the Base Cap?
  • Do not remove the Base Cap. Throw away the Pen and get a new Pen.
  • What if there is a drop of liquid on the tip of the needle when I remove the Base Cap?
  • A drop of liquid on the tip of the needle is normal.
  • Do I need to hold the Injection Button down until the injection is complete?
  • This is not necessary, but it may help you keep the Pen steady and firm against your skin.
  • I heard more than 2 clicks during my injection—2 louder clicks and 1 soft one. Did I get my complete injection?
  • Some people may hear a soft click right before the second loud click. That is the normal operation of the Pen. Do not remove the Pen from your skin until you hear the second louder click.
  • What if there is a drop of liquid or blood on my skin after my injection?
  • This is normal.
  • I am not sure if my Pen worked the right way.
  • Check to see if you have received your dose. Your dose was delivered the right way if the gray plunger is visible (see step 3). Also contact Lilly at 1-800-Lilly-Rx (1-800-545-5979) for further instructions. Until then, store your Pen safely to avoid an accidental needle stick.
  • If you have vision problems, do not use your Pen without help from a person trained to use the Trulicity Pen.
  • If you have any questions or problems with your Trulicity Single-Dose Pen, contact Lilly at 1-800-Lilly-Rx (1-800-545-5979) or call your healthcare provider.
  • Scan this code to launch www.trulicity.com
  • Eli Lilly and Company Indianapolis, IN 46285, USA US License Number 1891 Trulicity is a registered trademark of Eli Lilly and Company.
  • The Trulicity Pen meets the current dose accuracy and functional requirements of ISO 11608-1:2012 and 11608-5:2012.
  • Implemented: 04/2023
  • TRU3MG-0002-IFU-20230407
Instructions for Use

Trulicity: 4.5 mg single-dose pen

Every step, in the label's own words
  • Instructions for Use
  • Trulicity (TRU-li-si-tee) (dulaglutide) injection, for subcutaneous use 4.5 mg/0.5 mL Single-Dose Pen use 1 time each week (once weekly)
  • Information About Trulicity Single-Dose Pen
  • Please read this Instructions for Use and the Medication Guide carefully and completely before using your Trulicity Single-Dose Pen. Talk to your healthcare provider about how to inject Trulicity the right way.
  • Trulicity Single-Dose Pen (Pen) is a disposable, prefilled medicine delivery device. Each Pen contains 1 dose of Trulicity (4.5 mg/0.5 mL). Each Pen should only be used 1 time.
  • Trulicity is used 1 time each week. You may want to mark your calendar to remind you when to take your next dose.
  • Before You Get Started
  • Remove Check Inspect Prepare
  • Remove the Pen from the refrigerator. Leave the Base Cap on until you are ready to inject. Check the Pen label to make sure you have the right medicine and it has not expired. Expiration Date Check the Pen to make sure that it is not damaged and inspect the medicine to make sure it is not cloudy, discolored or has particles in it. Wash your hands.
  • Choose Your Injection Site
  • Your healthcare provider can help you choose the injection site that is best for you.
  • Change (rotate) your injection site each week. You may use the same area of your body, but be sure to choose a different injection site in that area. You may inject the medicine into your stomach (abdomen) or thigh.
  • Another person should give you the injection in the back of your upper arm.
  • Step 1 Uncap the Pen Make sure the Pen is locked. Pull the Base Cap straight off and throw it away in your household trash. Do not put the Base Cap back on — this could damage the needle. Do not touch the needle.
  • Step 2 Place and Unlock Place the Clear Base flat and firmly against your skin at the injection site. Unlock by turning the Lock Ring.
  • Step 3 Press and Hold Press and hold the green Injection Button. You will hear a loud click. Continue holding the Clear Base firmly against your skin until you hear a second click. This happens when the needle starts retracting in about 5-10 seconds. Remove the Pen from your skin.
  • Important Information
  • Disposal of Pen
  • Storage and Handling
  • Commonly Asked Questions
  • Other Information
  • Where to Learn More
  • Disposing of Your Used Pens Put your used Pens in a FDA-cleared sharps disposal container right away after use. Do not throw away (dispose of) Pens in your household trash. If you do not have a FDA-cleared sharps disposal container, you may use a household container that is: - made of a heavy-duty plastic, - can be closed with a tight-fitting, puncture-resistant lid, without sharps being able to come out, - upright and stable during use, - leak-resistant, and - properly labeled to warn of hazardous waste inside the container. When your sharps disposal container is almost full, you will need to follow your community guidelines for the right way to dispose of your sharps disposal container. There may be state or local laws about how you should throw away used needles and syringes. For more information about safe sharps disposal, and for specific information about sharps disposal in the state that you live in, go to the FDA's website at: http://www.fda.gov/safesharpsdisposal. Do not recycle your used sharps disposal container.
  • Store your Pen in the refrigerator between 36°F to 46°F (2°C to 8°C).
  • You may store your Pen at room temperature below 86°F (30°C) for a total of 14 days.
  • Do not freeze your Pen. If the Pen has been frozen, throw the Pen away and use a new Pen.
  • Storage of your Pen in the original carton is recommended. Protect your Pen from direct heat and light.
  • The Pen has glass parts. Handle it carefully. If you drop it on a hard surface, do not use it. Use a new Pen for your injection.
  • Keep your Trulicity Pen and all medicines out of the reach of children.
  • What if I see air bubbles in my Pen?
  • Air bubbles are normal.
  • What if I unlock the Pen and press the green Injection Button before pulling off the Base Cap?
  • Do not remove the Base Cap. Throw away the Pen and get a new Pen.
  • What if there is a drop of liquid on the tip of the needle when I remove the Base Cap?
  • A drop of liquid on the tip of the needle is normal.
  • Do I need to hold the Injection Button down until the injection is complete?
  • This is not necessary, but it may help you keep the Pen steady and firm against your skin.
  • I heard more than 2 clicks during my injection—2 louder clicks and 1 soft one. Did I get my complete injection?
  • Some people may hear a soft click right before the second loud click. That is the normal operation of the Pen. Do not remove the Pen from your skin until you hear the second louder click.
  • What if there is a drop of liquid or blood on my skin after my injection?
  • This is normal.
  • I am not sure if my Pen worked the right way.
  • Check to see if you have received your dose. Your dose was delivered the right way if the gray plunger is visible (see step 3). Also contact Lilly at 1-800-Lilly-Rx (1-800-545-5979) for further instructions. Until then, store your Pen safely to avoid an accidental needle stick.
  • If you have vision problems, do not use your Pen without help from a person trained to use the Trulicity Pen.
  • If you have any questions or problems with your Trulicity Single-Dose Pen, contact Lilly at 1-800-Lilly-Rx (1-800-545-5979) or call your healthcare provider.
  • Scan this code to launch www.trulicity.com
  • The Trulicity Pen meets the current dose accuracy and functional requirements of ISO 11608-1:2012 and 11608-5:2012.
  • Implemented: 04/2023
  • TRU4.5MG-0002-IFU-20230407
Questions

Using Trulicity: common questions

How do you inject Trulicity?

Follow the FDA-approved Instructions for Use for your product, listed on this page. They differ by product: 0.75 mg single-dose pen; 1.5 mg single-dose pen; 3 mg single-dose pen; 4.5 mg single-dose pen. Your healthcare provider should show you how before your first dose.

Do you need to change where you inject Trulicity?

From its FDA label: Rotate injection sites with each dose.

GLPcompare is an informational data platform, not a medical provider or pharmacy. Nothing here is medical advice, a diagnosis, or a recommendation to start, stop, or change any treatment. Data is aggregated from public sources and can be incomplete or out of date. Always confirm with a licensed clinician and the current FDA label.