Compounded semaglutide and tirzepatide with B12, B6 or glycine
Read Nov 6, 2026
Of 85 US sellers whose pages we read, 16 state an additive in their compounded semaglutide or tirzepatide, most often B12, glycine, and B6. An additive does not make a compounded drug FDA-approved, and the FDA has told one pharmacy that such products "appear to be essentially copies of FDA-approved semaglutide and tirzepatide products." FDA letter (FDA warning letter to Empower Pharmacy)
What the FDA has written about these products
From its warning letter of Sep 18, 2026 to Empower Pharmacy. It is about that pharmacy's products, and it is the FDA's clearest statement on additives we have read.
“Specifically, your firm compounded products including TIRZEPATIDE/NIACINAMIDE (4 ML)(17/2 MG/ML), SEMAGLUTIDE/CYANOCOBALAMIN (1 ML)(5/0.5 MG/ML), and TIRZEPATIDE/NIACINAMIDE (2.5 ML)(8/2 MG/ML), which appear to be essentially copies of FDA-approved semaglutide and tirzepatide products.”
“The volume of products you are producing suggests that differences between products you are compounding and the FDA-approved products are pretextual.”
Compounded GLP-1 with B12
Sellers in price order, with each one's lowest current compounded price and its own words.
Wellmedr · semaglutide: from $41/mo
“Compounded Semaglutide injection formulated with NAD+ and Vitamin B12 to help support balanced energy, focus, and metabolic performance.” source (wellmedr.com) (Wellmedr source)View offer
CoreAge Rx · tirzepatide: from $129/mo
“Our compounded tirzepatide is typically formulated with B-12.” source (coreagerx.com) (CoreAge Rx source)View offer
Eden · semaglutide and tirzepatide: $129/mo
“(B3, B6, B12, or glycine when appropriate)” source (eden.health) (Eden source)View offer
Telos Rx · tirzepatide: from $139/mo
“You can also add B12 to your GLP-1 protocol to help minimize nausea, your clinician can include it when it's a good fit for you.” source (telosrx.com) (Telos Rx source)View offer
Ondra Health · semaglutide and tirzepatide: $149/mo
“Vials RX (B12 or Glycine)” source (ondra.health) (Ondra Health source)View offer
OrderlyMeds · semaglutide: $149/mo
“your medication may include supportive supplements (like B6 or B12), as selected by your prescriber.” source (orderlymeds.com) (OrderlyMeds source)View offer
Ozari Health · semaglutide and tirzepatide: $175/mo
“Two plans. Ozari One is semaglutide with B12, billed every three months, at the lower price.” source (ozarihealth.com) (Ozari Health source)View offer
Join Luma · tirzepatide: $219/mo
“a formulation with a glycine or vitamin B12 additive is prepared by VialsRx Pharmacy” source (joinluma.com) (Join Luma source)View offer
Peak Wellness · semaglutide and tirzepatide: $249/mo
“Semaglutide or tirzepatide base, the form used in the clinical research, not the cheaper salt form some compounders use. Stabilized with glycine, with vitamin B12.” source (trypeak.com) (Peak Wellness source)View offer
Found · semaglutide and tirzepatide: $289/28 days
“Your compounded semaglutide + B12/Glycine is prepared by a licensed compounding pharmacy and shipped to your door.” source (joinfound.com) (Found source)View offer
Lemonaid Health · semaglutide: $348/mo
“Added B12 support, may help sustain energy” source (lemonaidhealth.com) (Lemonaid Health source)View offer
Compounded GLP-1 with B6
Sellers in price order, with each one's lowest current compounded price and its own words.
Pepti · semaglutide: $99/28 days
“paired with B6 to ease nausea.” source (hellopepti.com) (Pepti source)View offer
Eden · semaglutide and tirzepatide: $129/mo
“(B3, B6, B12, or glycine when appropriate)” source (eden.health) (Eden source)View offer
Brello Health · semaglutide: $133/mo average
“Compounded Semaglutide With B6 (Pyridoxine)” source (brellohealth.com) (Brello Health source)View offer
Ondra Health · semaglutide and tirzepatide: $149/mo
“Southend Pharmacy (B6)” source (ondra.health) (Ondra Health source)View offer
OrderlyMeds · semaglutide: $149/mo
“your medication may include supportive supplements (like B6 or B12), as selected by your prescriber.” source (orderlymeds.com) (OrderlyMeds source)View offer
MangoRx · semaglutide: $299/30 days
“Slim is a compounded medication that combines Semaglutide with Vitamin B6 in oral dissolving tablets (ODT).” source (mangorx.com) (MangoRx source)View offer
Compounded GLP-1 with B3 (niacinamide)
Sellers in price order, with each one's lowest current compounded price and its own words.
Eden · semaglutide and tirzepatide: $129/mo
“(B3, B6, B12, or glycine when appropriate)” source (eden.health) (Eden source)View offer
Ondra Health · semaglutide and tirzepatide: $149/mo
“Optio RX (B3 as Niacinamide)” source (ondra.health) (Ondra Health source)View offer
Compounded GLP-1 with Glycine
Sellers in price order, with each one's lowest current compounded price and its own words.
Eden · semaglutide and tirzepatide: $129/mo
“(B3, B6, B12, or glycine when appropriate)” source (eden.health) (Eden source)View offer
PreventiveMD · tirzepatide: $139/mo
“When my Tirzepatide / Glycine vials from Empower Pharmacy arrive, should I store them in the freezer or the fridge?” source (preventivemd.com) (PreventiveMD source)View offer
Ondra Health · semaglutide and tirzepatide: $149/mo
“Boudreaux's New Drug Store (Glycine)” source (ondra.health) (Ondra Health source)View offer
Ozari Health · semaglutide and tirzepatide: $175/mo
“Three formulations: with B12, with glycine, or no additives” source (ozarihealth.com) (Ozari Health source)View offer
Tomorrow · semaglutide and tirzepatide: $199/mo
“It is compounded with glycine by a licensed 503A pharmacy” source (trytomorrow.com) (Tomorrow source)View offer
Join Luma · tirzepatide: $219/mo
“a formulation with a glycine or vitamin B12 additive is prepared by VialsRx Pharmacy” source (joinluma.com) (Join Luma source)View offer
Peak Wellness · semaglutide and tirzepatide: $249/mo
“Semaglutide or tirzepatide base, the form used in the clinical research, not the cheaper salt form some compounders use. Stabilized with glycine, with vitamin B12.” source (trypeak.com) (Peak Wellness source)View offer
Found · semaglutide and tirzepatide: $289/28 days
“Your compounded semaglutide + B12/Glycine is prepared by a licensed compounding pharmacy and shipped to your door.” source (joinfound.com) (Found source)View offer
Compounded GLP-1 with NAD+
Sellers in price order, with each one's lowest current compounded price and its own words.
Wellmedr · semaglutide: from $41/mo
“Compounded Semaglutide injection formulated with NAD+ and Vitamin B12 to help support balanced energy, focus, and metabolic performance.” source (wellmedr.com) (Wellmedr source)View offer
Sellers that state a formulation with no additives
Most sellers' pages do not say either way, so ask before you pay.
Join Luma: $149/mo
“the additive-free formulation is prepared by Hallandale Pharmacy where it ships.”View offer
Ondra Health: $149/mo
“Hallandale Pharmacy and Quaker Community / New Life RX offer no-additive formulations.”View offer
Ozari Health: $175/mo
“Ozari Select also offers a formulation with glycine and one with no additives.”View offer
Who makes these products: which pharmacy each seller names.
GLPcompare links out only to sellers with a referral program: if you sign up or buy through one of those links, we may earn a commission at no extra cost to you. For other sellers we show the price and the seller's address, and suggest sellers we can link to. It never changes the price you pay or the underlying data. Partner status and commission rates contribute to offer and provider value scores and can change their order. Every partner is labeled. Value scores are not medical recommendations; a higher-ranked offer is not necessarily the lowest price or the right product for you.
Common questions
Why is B12 or glycine added to compounded tirzepatide or semaglutide?
Sellers give their own reasons, quoted on this page. In a letter to one pharmacy the FDA wrote: "The volume of products you are producing suggests that differences between products you are compounding and the FDA-approved products are pretextual." GLPcompare makes no claim that an additive does anything. A clinician can say whether it matters for you.
Does adding B12 make compounded tirzepatide legal or FDA-approved?
It does not make it FDA-approved. Compounded drugs are not FDA-approved: the FDA does not review them for safety, effectiveness or quality before they are marketed. In its letter of Sep 18, 2026 to Empower Pharmacy, the FDA wrote: "Specifically, your firm compounded products including TIRZEPATIDE/NIACINAMIDE (4 ML)(17/2 MG/ML), SEMAGLUTIDE/CYANOCOBALAMIN (1 ML)(5/0.5 MG/ML), and TIRZEPATIDE/NIACINAMIDE (2.5 ML)(8/2 MG/ML), which appear to be essentially copies of FDA-approved semaglutide and tirzepatide products."
Which sellers offer compounded tirzepatide without additives?
Join Luma: "the additive-free formulation is prepared by Hallandale Pharmacy where it ships." Ondra Health: "Hallandale Pharmacy and Quaker Community / New Life RX offer no-additive formulations." Ozari Health: "Ozari Select also offers a formulation with glycine and one with no additives." Read Nov 6, 2026. Most sellers' pages do not say either way, so ask before you pay.
Which compounded GLP-1 sellers add B12?
Wellmedr, CoreAge Rx, Eden, Telos Rx, Ondra Health, OrderlyMeds, Ozari Health, Join Luma, Peak Wellness, Found, Lemonaid Health state it on their own pages, read Nov 6, 2026. A seller may offer it only on some plans or when its prescriber selects it: the words beside each name say which.