Which GLP-1 gives the most weight loss for the money?
Prices checked through Nov 4, 2026
By cost per 1% of body weight lost in its pivotal trial, Wegovy pill is lowest at about $329, and the rest run up to about $448. People on Zepbound lost the most weight, 20.9%, at about $387 per 1%. These figures take today's lowest self-pay price at the trial's dose over the trial's length; the trials enrolled different people and ran for different times, so they are a guide to value and not a head-to-head result.
Cost per 1% of body weight lost
Lowest first. The price at the trial's dose, carried over the trial's length, divided by the mean percent lost.
Wegovy pill at 25 mg
about $329 per 1%
13.6% of body weight at 64 weeks in OASIS 4 source (OASIS 4 source). Lowest price at that dose: $299/mo at NovoCare (Novo Nordisk), checked Nov 4, 2026. About $4,470 over 64 weeks.View offer
Wegovy HD at 7.2 mg
about $384 per 1%
18.7% of body weight at 72 weeks in STEP UP source (STEP UP source). Lowest price at that dose: $399/28 days at NovoCare (Novo Nordisk), checked Nov 4, 2026. About $7,180 over 72 weeks.View offer
Zepbound at 15 mg
about $387 per 1%
20.9% of body weight at 72 weeks in SURMOUNT-1 source (SURMOUNT-1 source). Lowest price at that dose: $449/28 days at LillyDirect (Eli Lilly), checked Nov 4, 2026. About $8,080 over 72 weeks.View offer
Wegovy injection at 2.4 mg
about $398 per 1%
14.9% of body weight at 68 weeks in STEP 1 source (STEP 1 source). Lowest price at that dose: $349/28 days at NovoCare (Novo Nordisk), checked Nov 4, 2026. About $5,930 over 68 weeks.View offer
Foundayo at 17.2 mg
about $448 per 1%
11.2% of body weight at 72 weeks in ATTAIN-1 source (ATTAIN-1 source). Lowest price at that dose: $299/mo at LillyDirect (Eli Lilly), checked Nov 4, 2026. About $5,020 over 72 weeks.View offer
What this figure does and does not say
- The trials are separate. They enrolled different people and ran for different lengths, so a small gap between two rows may mean little.
- It counts the full-dose price from the first week. A course that starts on lower doses often costs less while the dose rises, for every medication alike.
- It leaves out any membership a seller adds, and a trial average is not what any one person will lose.
- It says nothing about side effects or which medicine suits you. A clinician can.
GLPcompare links out only to sellers with a referral program: if you sign up or buy through one of those links, we may earn a commission at no extra cost to you. For other sellers we show the price and the seller's address, and suggest sellers we can link to. It never changes the price you pay or the underlying data. Partner status and commission rates contribute to offer and provider value scores and can change their order. Every partner is labeled. Value scores are not medical recommendations; a higher-ranked offer is not necessarily the lowest price or the right product for you.
Common questions
Which GLP-1 is the best value for weight loss?
By cost per 1% of body weight lost in its pivotal trial, Wegovy pill is lowest at about $329, and the rest run up to about $448. People on Zepbound lost the most weight, 20.9%, at about $387 per 1%. These figures take today's lowest self-pay price at the trial's dose over the trial's length; the trials enrolled different people and ran for different times, so they are a guide to value and not a head-to-head result.
Which GLP-1 causes the most weight loss?
Among those with a price stated at their trial dose, Zepbound at 15 mg: a mean of 20.9% of body weight at 72 weeks in SURMOUNT-1. Individual results vary, and a clinician can say which is right for you.
How is the cost per 1% worked out?
The lowest self-pay price at the dose the trial tested, per 30 days, carried over the length of the trial, divided by the mean percent of body weight lost. It counts the full-dose price from the first week, so it overstates what a course costs while the dose is rising, for every medication alike. It leaves out any membership a seller adds.
Why is compounded semaglutide or tirzepatide not on this list?
No pivotal trial tested a compounded product, so there is no result to set a compounded price against. Compounded drugs are not FDA-approved: the FDA does not review them for safety, effectiveness or quality before they are marketed.