US self-pay prices · compounded, not FDA-approved

Microdose GLP-1 prices

13 US sellers publish a price for a microdose GLP-1 plan: compounded semaglutide or tirzepatide at a dose below the maintenance doses on the FDA labels. Advertised prices run from $79/mo for microdose semaglutide at CoreAge Rx (a starting price) to $274.99/mo for microdose tirzepatide at Ivim Health. 3 state the supply the price buys; the lowest of those is ≈ $138 per 30 days for microdose semaglutide at NiceRx. Every price below shows its seller, terms and check date.

Compare all 23 microdose plansMicrodose vs regular plan, by seller

Lowest with a stated supply

≈ $138 per 30 days, ranked among 3 plans that state what the price buys

Advertised price

$129/28 days

28-day supply

≈ $138.21 per 30 days at this quoted rate

Checked

Microdose semaglutide via NiceRx

NiceRx · Sourced provider quote

monthly plan billed every 4 weeks; $249 every 12 weeks on 3 months, $459 every 24 weeks on 6 months, $799 every 48 weeks on 12 months; 0.25 or 0.5 mg weekly at one price; clinician evaluation, medication and delivery included, no membership fee

Price conditions

monthly plan billed every 4 weeks; $249 every 12 weeks on 3 months, $459 every 24 weeks on 6 months, $799 every 48 weeks on 12 months; 0.25 or 0.5 mg weekly at one price; clinician evaluation, medication and delivery included, no membership fee

Available in most U.S. states; the card is charged only if a clinician prescribes. Compounded; not FDA-approved.

28-day supply

View offer

Lowest advertised

No verified supply period, so not ranked per 30 days

Advertised price

from $79/mo

Supply period unverified; excluded from cost ranking.

Checked

Microdose semaglutide via CoreAge Rx

CoreAge Rx · Sourced provider quote

starting price; no membership fees and no long-term contract

Price conditions

starting price; no membership fees and no long-term contract

The same starting price as CoreAge Rx's regular compounded semaglutide. Compounded; not FDA-approved.

View offer

By ingredient

Every cash quote was checked on or after . Each quote shows its own check date. A quoted plan is not a recommendation of a product or a dose. How we source prices

Microdose plans are compounded, off-label and untested in published trials.

Compounded drugs are not FDA-approved: the FDA does not review them for safety, effectiveness or quality before they are marketed. FDA: concerns with unapproved GLP-1 drugs used for weight loss

Wegovy's label starts the injection at 0.25 mg once weekly for 4 weeks, then raises the dose every 4 weeks; the maintenance dosage for weight reduction in adults is 1.7 mg or 2.4 mg (recommended) once weekly. Wegovy prescribing information (DailyMed, June 30, 2026)

Zepbound's label says the 2.5 mg dosage is for treatment initiation and is not approved as a maintenance dosage; the recommended maintenance dosage for weight reduction is 5 mg, 10 mg or 15 mg once weekly. Zepbound prescribing information (DailyMed, September 2, 2026)

ClinicalTrials.gov lists 3 registered studies of GLP-1 microdosing, none with posted results (checked Oct 19, 2026): AgelessRx's randomized, placebo-controlled early phase 1 trial of microdosed GLP-1 for health, quality of life and longevity measures, planned for 150 people, enrolling by invitation NCT07092605; a University of Texas Health Science Center at Houston phase 2 trial of semaglutide 0.5 mg weekly after a 2 mg course, against stopping, planned for 30 people with HIV, recruiting NCT07325500; Noom's observational cohort (FLOURISH) comparing microdose and standard-dose compounded semaglutide and tirzepatide over 24 months, not yet recruiting NCT07588984.

Every sourced plan

All microdose GLP-1 plans

Telehealth microdose plans for compounded semaglutide and tirzepatide, lowest 30-day cost first where the seller states its supply. Regular compounded plans are on their own price pages.

23 offers · US self-pay

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  • Microdose semaglutide via NiceRx

    Semaglutide · Compounded

    Compounded · Not FDA-approved
    N
    NiceRx
    Advertised price$129/28 days

    28-day supply

    ≈ $138.21 per 30 days

    Checked

    Maintenance price

    No separate dose price verified

    View offer
    Price conditions & source

    Advertised price: monthly plan billed every 4 weeks; $249 every 12 weeks on 3 months, $459 every 24 weeks on 6 months, $799 every 48 weeks on 12 months; 0.25 or 0.5 mg weekly at one price; clinician evaluation, medication and delivery included, no membership fee

    Available in most U.S. states; the card is charged only if a clinician prescribes. Compounded; not FDA-approved.

    Confirm the prescribed dose, supply length, membership or consultation fees, and refill conditions with the provider. A listed offer does not confirm eligibility or stock.

    Read the advertised-price source
  • Microdose tirzepatide via Enhance.MD

    Tirzepatide · Compounded

    Compounded · Not FDA-approved
    EM
    Enhance.MD
    Advertised price$169/mo

    28-day supply · 12-month upfront payment required

    ≈ $181.07 per 30 days

    Checked

    Maintenance price

    No separate dose price verified

    View offer
    Price conditions & source

    Advertised price: 12-month plan billed every 48 weeks; $179/mo on 6 months, $189/mo on 3 months; 1 mg weekly; medication delivered every 12 weeks, provider care and shipping included

    The page publishes no price for its 1-month plan. Compounded; not FDA-approved.

    Confirm the prescribed dose, supply length, membership or consultation fees, and refill conditions with the provider. A listed offer does not confirm eligibility or stock.

    Read the advertised-price source
  • Microdose tirzepatide via NiceRx

    Tirzepatide · Compounded

    Compounded · Not FDA-approved
    N
    NiceRx
    Advertised price$169/28 days

    28-day supply

    ≈ $181.07 per 30 days

    Checked

    Maintenance price

    No separate dose price verified

    View offer
    Price conditions & source

    Advertised price: monthly plan billed every 4 weeks; $465 every 12 weeks on 3 months, $840 every 24 weeks on 6 months, $1,548 every 48 weeks on 12 months; 2.5 or 5 mg weekly at one price; clinician evaluation, medication and delivery included, no membership fee

    On 3-month plans NiceRx's regular compounded tirzepatide ($449 every 12 weeks) costs less than this microdose plan ($465). Available in most U.S. states. Compounded; not FDA-approved.

    Confirm the prescribed dose, supply length, membership or consultation fees, and refill conditions with the provider. A listed offer does not confirm eligibility or stock.

    Read the advertised-price source
  • Microdose semaglutide via AgelessRx

    Semaglutide · Compounded

    Compounded · Not FDA-approved
    A
    AgelessRx
    Advertised price$99/mo

    4-month upfront payment required

    Supply period unverified; excluded from cost ranking.

    Checked

    Maintenance price

    No separate dose price verified

    View offer
    Price conditions & source

    Advertised price: 4-month plan billed in full, then $159/mo; monthly and 2-month plans also offered at prices shown during sign-up; pause or cancel anytime

    Weekly injection formulated with glycine; HSA and FSA accepted. Compounded; not FDA-approved.

    Confirm the prescribed dose, supply length, membership or consultation fees, and refill conditions with the provider. A listed offer does not confirm eligibility or stock.

    Read the advertised-price source
  • Microdose semaglutide via bmiMD

    Semaglutide · Compounded

    Compounded · Not FDA-approved
    B
    bmiMD
    Advertised price$129/mo

    Supply period unverified; excluded from cost ranking.

    Checked

    Maintenance price

    No separate dose price verified

    View offer
    Price conditions & source

    Advertised price: 1-month plan; $119/mo on 3 months ($357), $109/mo on 6 months ($654), $99/mo on 12 months ($1,188), each billed for the period and shown as a limited-time price; free shipping and clinician access included

    A subscription that can be cancelled at any time; fully refunded if you are not eligible. Compounded; not FDA-approved.

    Confirm the prescribed dose, supply length, membership or consultation fees, and refill conditions with the provider. A listed offer does not confirm eligibility or stock.

    Read the advertised-price source
  • Microdose semaglutide via CoreAge Rx

    Semaglutide · Compounded

    Compounded · Not FDA-approved
    CR
    CoreAge Rx
    Advertised pricefrom $79/mo

    Supply period unverified; excluded from cost ranking.

    Checked

    Maintenance price

    No separate dose price verified

    View offer
    Price conditions & source

    Advertised price: starting price; no membership fees and no long-term contract

    The same starting price as CoreAge Rx's regular compounded semaglutide. Compounded; not FDA-approved.

    Confirm the prescribed dose, supply length, membership or consultation fees, and refill conditions with the provider. A listed offer does not confirm eligibility or stock.

    Read the advertised-price source
  • Microdose semaglutide via Direct Meds

    Semaglutide · Compounded

    Compounded · Not FDA-approved
    DM
    Direct Meds
    Advertised price$129/mo

    Supply period unverified; excluded from cost ranking.

    Checked

    Maintenance price

    No separate dose price verified

    View offer
    Price conditions & source

    Advertised price: monthly subscription, 90-day supply option; 0.25 to 0.5 mg weekly; free shipping, no membership fee, cancel anytime

    Direct Meds says this program is for longevity and metabolic health support, not for active weight loss. Compounded; not FDA-approved.

    Confirm the prescribed dose, supply length, membership or consultation fees, and refill conditions with the provider. A listed offer does not confirm eligibility or stock.

    Read the advertised-price source
  • Microdose semaglutide tablets via Fridays

    Semaglutide · Compounded

    Compounded · Not FDA-approved
    F
    Fridays
    Advertised price$249/mo

    Supply period unverified; excluded from cost ranking.

    Checked

    Maintenance price

    No separate dose price verified

    View offer
    Price conditions & source

    Advertised price: monthly price of the daily oral tablet on Fridays' microdosing page

    Prescribed only if a clinician finds it appropriate; not available in all 50 states. Compounded; not FDA-approved.

    Confirm the prescribed dose, supply length, membership or consultation fees, and refill conditions with the provider. A listed offer does not confirm eligibility or stock.

    Read the advertised-price source
  • Microdose semaglutide via Ivim Health

    Semaglutide · Compounded

    Compounded · Not FDA-approved
    IH
    Ivim Health
    Advertised price$174.99/mo

    Calculated: $100 medication + $74.99 ongoing membership/provider fee. Charges billed separately.

    Separate billing cycles; excluded from cost ranking.

    Checked

    Maintenance price

    No separate dose price verified

    View offer
    Price conditions & source

    2-month plan; the medication is $75 a month on 4- or 6-month plans, and the $74.99 monthly program fee applies to each. BMI restrictions apply. Compounded; not FDA-approved.

    Confirm the prescribed dose, supply length, membership or consultation fees, and refill conditions with the provider. A listed offer does not confirm eligibility or stock.

    Read the advertised-price source
  • Microdose semaglutide via Lemonaid Health

    Semaglutide · Compounded

    Compounded · Not FDA-approved
    LH
    Lemonaid Health
    Advertised price$248/mo

    Calculated: $199 medication + $49 ongoing membership/provider fee. Charges billed separately.

    Separate billing cycles; excluded from cost ranking.

    Checked

    Maintenance price

    No separate dose price verified

    View offer
    Price conditions & source

    Monthly; the $49 membership is required. Compounded; not FDA-approved.

    Confirm the prescribed dose, supply length, membership or consultation fees, and refill conditions with the provider. A listed offer does not confirm eligibility or stock.

    Read the advertised-price source
  • Microdose semaglutide via Maximus

    Semaglutide · Compounded

    Compounded · Not FDA-approved
    M
    Maximus
    Advertised price$99.99/mo

    Supply period unverified; excluded from cost ranking.

    Checked

    Maintenance price

    No separate dose price verified

    View offer
    Price conditions & source

    Advertised price: starting dose 0.25 mg weekly; physician-supervised; compounded and shipped from a licensed U.S. pharmacy

    Maximus calls low-dose use an off-label use and says its microdosing protocol is not a weight-loss protocol. Compounded; not FDA-approved.

    Confirm the prescribed dose, supply length, membership or consultation fees, and refill conditions with the provider. A listed offer does not confirm eligibility or stock.

    Read the advertised-price source
  • Microdose GLP-1Rx via Noom Med

    Semaglutide · Compounded

    Compounded · Not FDA-approved
    N
    Noom
    Advertised price$179/mo

    Supply period unverified; excluded from cost ranking.

    Checked

    Maintenance price

    No separate dose price verified

    View offer
    Price conditions & source

    Advertised price: after $79 for the first 4 weeks of medication (a 3-week initial subscription), on a 12-week subscription, plus tax; medication and the Noom program included; final pricing depends on program selection

    Noom's microdose program offers compounded semaglutide and tirzepatide; its page states this one starting price. New-account pricing since July 27, 2026; not available in all states; HSA and FSA eligible. Noom has registered an observational study of its microdose programs (NCT07588984). Compounded; not FDA-approved.

    Confirm the prescribed dose, supply length, membership or consultation fees, and refill conditions with the provider. A listed offer does not confirm eligibility or stock.

    Read the advertised-price source

Read prices in context. Compare the same product, dose, and payment terms. A prepaid monthly rate is not a monthly payment. Cost order uses current, recently checked quotes with documented supply periods, converted to 30 days. Other prices are unranked references. Dose changes, introductory terms and added fees affect what you pay.

Missing prices are not estimated. A listed maintenance dose is not a dosing recommendation.

The FDA declared the tirzepatide (December 2024) and semaglutide (February 2025) shortages resolved, ending the exemption that let pharmacies mass-produce compounded copies, and the 503A/503B enforcement-discretion grace periods ended in 2025. The FDA is now actively enforcing (warning letters and takedowns, including a September 2026 warning letter to Empower Pharmacy, a large compounder, over products it called essentially copies of approved semaglutide and tirzepatide), and in 2026 proposed permanently excluding semaglutide, tirzepatide, and liraglutide from the 503B bulks list (the public comment period, extended 30 days, closed July 30, 2026; a final decision is pending). Liraglutide is different: it is still on the FDA drug shortage list (brand Victoza and Saxenda in limited supply, generics available, as of September 2026). Compounded GLP-1s are not FDA-approved and are now generally limited to narrow, patient-specific 503A prescriptions, so broad low-cost availability has largely wound down. They also carry safety risks the branded products do not: FDA adverse-event reports, at least one sterility recall (ProRx, October 2025), and counterfeit product found in the US supply chain, so a low price is not a low-risk signal. Prices and availability below may lag these changes; confirm current terms with the provider.

Some outbound links on GLPcompare are referral links. If you sign up or buy through one, we may earn a commission at no extra cost to you. It never changes the price you pay or the underlying data. Partner status and commission rates contribute to offer and provider value scores and can change their order. Every partner is labeled. Value scores are not medical recommendations; a higher-ranked offer is not necessarily the lowest price or the right product for you.

Some outbound links on GLPcompare are referral links. If you sign up or buy through one, we may earn a commission at no extra cost to you. It never changes the price you pay or the underlying data. Partner status and commission rates contribute to offer and provider value scores and can change their order. Every partner is labeled. Value scores are not medical recommendations; a higher-ranked offer is not necessarily the lowest price or the right product for you.

Seller by seller

Microdose cost at each seller

Each seller's microdose plan beside its own regular plan of the same ingredient. A saving is stated only when both prices say what they buy.

AgelessRx microdose GLP-1 cost

  • Microdose semaglutide: $99/mo. 4-month plan billed in full, then $159/mo; monthly and 2-month plans also offered at prices shown during sign-up; pause or cancel anytime. Weekly injection formulated with glycine; HSA and FSA accepted. Checked Oct 19, 2026, source (AgelessRx price source).
  • Microdose tirzepatide: $159/mo. Billed $318 every 2 months after a $109 first month; clinician-guided dosing, protocol adjustments and messaging included; cancel anytime. Formulated with glycine; HSA and FSA accepted. AgelessRx sponsors a placebo-controlled trial of microdosed GLP-1 (NCT07092605). Checked Oct 19, 2026, source (AgelessRx price source).
Every AgelessRx price

bmiMD microdose GLP-1 cost

  • Microdose semaglutide: $129/mo. 1-month plan; $119/mo on 3 months ($357), $109/mo on 6 months ($654), $99/mo on 12 months ($1,188), each billed for the period and shown as a limited-time price; free shipping and clinician access included. A subscription that can be cancelled at any time; fully refunded if you are not eligible. Checked Oct 19, 2026, source (bmiMD price source).Regular compounded semaglutide plan: $159/mo.
  • Microdose tirzepatide: $179/mo. 1-month plan; $159/mo on 3 months ($477), $149/mo on 6 months ($894), $139/mo on 12 months ($1,668), each billed for the period and shown as a limited-time price; free shipping and clinician access included. A subscription that can be cancelled at any time; fully refunded if you are not eligible. Checked Oct 19, 2026, source (bmiMD price source).Regular compounded tirzepatide plan: $249/mo.
Every bmiMD price

CoreAge Rx microdose GLP-1 cost

  • Microdose semaglutide: from $79/mo. Starting price; no membership fees and no long-term contract. The same starting price as CoreAge Rx's regular compounded semaglutide. Checked Oct 19, 2026, source (CoreAge Rx price source).Regular compounded semaglutide plan: from $79/mo.
  • Microdose tirzepatide: from $129/mo. Starting price; no membership fees and no long-term contract. The same starting price as CoreAge Rx's regular compounded tirzepatide. Checked Oct 19, 2026, source (CoreAge Rx price source).Regular compounded tirzepatide plan: from $129/mo.
Every CoreAge Rx price

Direct Meds microdose GLP-1 cost

  • Microdose semaglutide: $129/mo. Monthly subscription, 90-day supply option; 0.25 to 0.5 mg weekly; free shipping, no membership fee, cancel anytime. Direct Meds says this program is for longevity and metabolic health support, not for active weight loss. Checked Oct 19, 2026, source (Direct Meds price source).Regular compounded semaglutide plan: $297/mo.
  • Microdose tirzepatide: $149/mo. Monthly subscription, 90-day supply option; 2.5 to 5 mg weekly; free shipping, no membership fee, cancel anytime. Direct Meds says this program is for longevity and metabolic health support, not for active weight loss. Checked Oct 19, 2026, source (Direct Meds price source).Regular compounded tirzepatide plan: $399/mo.
Every Direct Meds price

Enhance.MD microdose GLP-1 cost

  • Microdose tirzepatide: $169/mo (≈ $181 per 30 days). 12-month plan billed every 48 weeks; $179/mo on 6 months, $189/mo on 3 months; 1 mg weekly; medication delivered every 12 weeks, provider care and shipping included. The page publishes no price for its 1-month plan. Checked Oct 19, 2026, source (Enhance.MD price source).Regular compounded tirzepatide plan: from $280/mo, so the microdose plan is $119 less per 30 days than its regular plan.
Every Enhance.MD price

Fridays microdose GLP-1 cost

  • Microdose semaglutide tablets: $249/mo. Monthly price of the daily oral tablet on Fridays' microdosing page. Prescribed only if a clinician finds it appropriate; not available in all 50 states. Checked Oct 19, 2026, source (Fridays price source).
  • Microdose tirzepatide: $198/mo. Monthly price of the weekly injection on Fridays' microdosing page. Prescribed only if a clinician finds it appropriate; not available in all 50 states. Checked Oct 19, 2026, source (Fridays price source).Regular compounded tirzepatide plan: $259/mo.
Every Fridays price

Ivim Health microdose GLP-1 cost

  • Microdose semaglutide: $174.99/mo. Calculated: $100 medication + $74.99 ongoing membership/provider fee. 2-month plan; the medication is $75 a month on 4- or 6-month plans, and the $74.99 monthly program fee applies to each. BMI restrictions apply. Checked Oct 19, 2026, source (Ivim Health price source).Regular compounded semaglutide plan: $224.99/mo.
  • Microdose tirzepatide: $274.99/mo. Calculated: $200 medication + $74.99 ongoing membership/provider fee. 2-month plan; the medication is $150 a month on 4 months and $133 on 6, and the $74.99 monthly program fee applies to each. BMI restrictions apply. Checked Oct 19, 2026, source (Ivim Health price source).Regular compounded tirzepatide plan: $324.99/mo.
Every Ivim Health price

Lemonaid Health microdose GLP-1 cost

  • Microdose semaglutide: $248/mo. Calculated: $199 medication + $49 ongoing membership/provider fee. Monthly; the $49 membership is required. Checked Oct 19, 2026, source (Lemonaid Health price source).Regular compounded semaglutide plan: $348/mo.
  • Microdose tirzepatide: $248/mo. Calculated: $199 medication + $49 ongoing membership/provider fee. Monthly; doses capped at 25% of the standard maintenance dose; the $49 membership is required. Checked Oct 19, 2026, source (Lemonaid Health price source).Regular compounded tirzepatide plan: $348/mo.
Every Lemonaid Health price

Maximus microdose GLP-1 cost

  • Microdose semaglutide: $99.99/mo. Starting dose 0.25 mg weekly; physician-supervised; compounded and shipped from a licensed U.S. pharmacy. Maximus calls low-dose use an off-label use and says its microdosing protocol is not a weight-loss protocol. Checked Oct 19, 2026, source (Maximus price source).
  • Microdose tirzepatide: $132.99/mo. Starting dose 1.5 mg weekly; physician-supervised; compounded and shipped from a licensed U.S. pharmacy. Maximus calls low-dose use an off-label use and says its microdosing protocol is not a weight-loss protocol. Checked Oct 19, 2026, source (Maximus price source).Regular compounded tirzepatide plan: $249.99/mo.
Every Maximus price

NiceRx microdose GLP-1 cost

  • Microdose semaglutide: $129/28 days (≈ $138 per 30 days). Monthly plan billed every 4 weeks; $249 every 12 weeks on 3 months, $459 every 24 weeks on 6 months, $799 every 48 weeks on 12 months; 0.25 or 0.5 mg weekly at one price; clinician evaluation, medication and delivery included, no membership fee. Available in most U.S. states; the card is charged only if a clinician prescribes. Checked Oct 19, 2026, source (NiceRx price source).Regular compounded semaglutide plan: $149/28 days, so the microdose plan is $21 less per 30 days than its regular plan.
  • Microdose tirzepatide: $169/28 days (≈ $181 per 30 days). Monthly plan billed every 4 weeks; $465 every 12 weeks on 3 months, $840 every 24 weeks on 6 months, $1,548 every 48 weeks on 12 months; 2.5 or 5 mg weekly at one price; clinician evaluation, medication and delivery included, no membership fee. On 3-month plans NiceRx's regular compounded tirzepatide ($449 every 12 weeks) costs less than this microdose plan ($465). Available in most U.S. states. Checked Oct 19, 2026, source (NiceRx price source).Regular compounded tirzepatide plan: $249/28 days, so the microdose plan is $86 less per 30 days than its regular plan.
Every NiceRx price

Noom microdose GLP-1 cost

  • Microdose GLP-1Rx: $179/mo. After $79 for the first 4 weeks of medication (a 3-week initial subscription), on a 12-week subscription, plus tax; medication and the Noom program included; final pricing depends on program selection. Noom's microdose program offers compounded semaglutide and tirzepatide; its page states this one starting price. New-account pricing since July 27, 2026; not available in all states; HSA and FSA eligible. Noom has registered an observational study of its microdose programs (NCT07588984). Checked Oct 19, 2026, source (Noom price source).Regular compounded semaglutide plan: $279/28 days.
Every Noom price

Shed microdose GLP-1 cost

  • Microdose semaglutide: from $149/mo. Starting price; 2-month minimum; provider-led plan. Checked Oct 19, 2026, source (Shed price source).Regular compounded semaglutide plan: $199/mo.
  • Microdose tirzepatide: from $199/mo. Starting price; 2-month minimum; provider-led plan. Checked Oct 19, 2026, source (Shed price source).Regular compounded tirzepatide plan: $299/mo.
Every Shed price

Telos Rx microdose GLP-1 cost

  • Microdose tirzepatide: from $116/mo. As low as, depending on plan length; the price does not change as the dose is adjusted; weekly injection; shipping, messaging, dose adjustments and quarterly labs included. FSA and HSA eligible; cancel anytime. Checked Oct 19, 2026, source (Telos Rx price source).Regular compounded tirzepatide plan: from $139/mo.
Every Telos Rx price
Every price, in words

Every microdose GLP-1 price

Plans that state what the price buys are ranked per 30 days; the rest are listed alphabetically with their own terms.

Ranked per 30 days

  1. NiceRx (microdose semaglutide): ≈ $138 per 30 days, advertised as $129/28 days. Checked Oct 19, 2026, source (NiceRx price source).
  2. Enhance.MD (microdose tirzepatide): ≈ $181 per 30 days, advertised as $169/mo (12 months paid upfront). Checked Oct 19, 2026, source (Enhance.MD price source).
  3. NiceRx (microdose tirzepatide): ≈ $181 per 30 days, advertised as $169/28 days. Checked Oct 19, 2026, source (NiceRx price source).

Not ranked: supply period not verified

Questions

Microdose GLP-1 cost: common questions

How much does microdosing GLP-1 cost without insurance?

13 US sellers publish a self-pay price for a microdose GLP-1 plan, checked Oct 19, 2026. Advertised prices run from $79/mo for microdose semaglutide at CoreAge Rx (a starting price) to $274.99/mo for microdose tirzepatide at Ivim Health. Among the 3 that state the supply the price buys, costs run from ≈ $138 per 30 days (microdose semaglutide at NiceRx) to ≈ $181 per 30 days (microdose tirzepatide at NiceRx). Every plan is compounded, and insurance does not cover compounded GLP-1s; these are the sellers' own advertised prices, and the conditions listed with each apply.

What is the cheapest microdose GLP-1?

Ranked per 30 days, the lowest is microdose semaglutide at NiceRx at ≈ $138 per 30 days (advertised as $129/28 days), then microdose tirzepatide at Enhance.MD (≈ $181 per 30 days) and microdose tirzepatide at NiceRx (≈ $181 per 30 days). The lowest advertised figure, $79/mo for microdose semaglutide at CoreAge Rx (a starting price), has no verified supply period, so it is not ranked per 30 days. Microdose plans are compounded and not FDA-approved, so a lower price says nothing about quality.

How much does microdose semaglutide cost?

11 sellers publish a microdose semaglutide price, from $79/mo for microdose semaglutide at CoreAge Rx (a starting price) to $249/mo for microdose semaglutide tablets at Fridays. The lowest that states its supply is ≈ $138 per 30 days for microdose semaglutide at NiceRx. Wegovy's label starts the injection at 0.25 mg once weekly for 4 weeks, then raises the dose every 4 weeks; the maintenance dosage for weight reduction in adults is 1.7 mg or 2.4 mg (recommended) once weekly. Regular compounded semaglutide prices

How much does microdose tirzepatide cost?

12 sellers publish a microdose tirzepatide price, from $116/mo for microdose tirzepatide at Telos Rx (a starting price) to $274.99/mo for microdose tirzepatide at Ivim Health. The lowest that states its supply is ≈ $181 per 30 days for microdose tirzepatide at Enhance.MD (12-month plan paid upfront) and NiceRx. Zepbound's label says the 2.5 mg dosage is for treatment initiation and is not approved as a maintenance dosage; the recommended maintenance dosage for weight reduction is 5 mg, 10 mg or 15 mg once weekly. Regular compounded tirzepatide prices

Does microdosing GLP-1 cost less than a regular plan?

Only the same seller's two plans can be compared, and only when both state their supply. 3 plans allow that: Enhance.MD's microdose tirzepatide is $119 less per 30 days than its regular plan; NiceRx's microdose semaglutide is $21 less per 30 days than its regular plan; NiceRx's microdose tirzepatide is $86 less per 30 days than its regular plan. At CoreAge Rx, the microdose plan is advertised at the same price as the regular plan.

Is GLP-1 microdosing FDA-approved?

No. Every microdose plan tracked here is compounded, and compounded drugs are not FDA-approved: the FDA does not review them for safety, effectiveness or quality before they are marketed. Wegovy's label starts the injection at 0.25 mg once weekly for 4 weeks, then raises the dose every 4 weeks; the maintenance dosage for weight reduction in adults is 1.7 mg or 2.4 mg (recommended) once weekly. Zepbound's label says the 2.5 mg dosage is for treatment initiation and is not approved as a maintenance dosage; the recommended maintenance dosage for weight reduction is 5 mg, 10 mg or 15 mg once weekly. A microdose is a dose below those maintenance doses, chosen by the prescriber. FDA: concerns with unapproved GLP-1 drugs used for weight loss

Has GLP-1 microdosing been tested in clinical trials?

Not with published results. ClinicalTrials.gov lists 3 registered studies of GLP-1 microdosing, none with posted results (checked Oct 19, 2026): AgelessRx's randomized, placebo-controlled early phase 1 trial of microdosed GLP-1 for health, quality of life and longevity measures, planned for 150 people (NCT07092605, enrolling by invitation); a University of Texas Health Science Center at Houston phase 2 trial of semaglutide 0.5 mg weekly after a 2 mg course, against stopping, planned for 30 people with HIV (NCT07325500, recruiting); Noom's observational cohort (FLOURISH) comparing microdose and standard-dose compounded semaglutide and tirzepatide over 24 months (NCT07588984, not yet recruiting). The weight-loss results on the FDA labels come from trials of the full maintenance doses. ClinicalTrials.gov: NCT07092605

GLPcompare is an informational data platform, not a medical provider or pharmacy. Nothing here is medical advice, a diagnosis, or a recommendation to start, stop, or change any treatment. Data is aggregated from public sources and can be incomplete or out of date. Always confirm with a licensed clinician and the current FDA label.