Zepbound dosage
The recommended starting dosage of ZEPBOUND for all indications is 2.5 mg injected subcutaneously once weekly for 4 weeks. The maximum dosage of ZEPBOUND for all indications is 15 mg injected subcutaneously once weekly.
Word for word from the FDA label on DailyMed (Eli Lilly and Company), revised , version 40. Read every day: a new FDA version updates this page by itself.
Zepbound dosage chart
The soonest the label's schedule allows. A clinician can go slower.
| When | Dose |
|---|---|
| Weeks 1 to 4 | 2.5 mg |
| Weeks 5 to 8 | 5 mg |
| Week 9 or later | 7.5 mgif needed and tolerated |
| Week 13 or later | 10 mgif needed and tolerated |
| Week 17 or later | 12.5 mgif needed and tolerated |
| Week 21 or later | 15 mgif needed and tolerated |
Zepbound dosing and administration
Recommended Dose Escalation Schedule
- The recommended starting dosage of ZEPBOUND for all indications is 2.5 mg injected subcutaneously once weekly for 4 weeks.
- The 2.5 mg dosage is for treatment initiation and is not approved as a maintenance dosage.
- Follow the dosage escalation below for all indications to reduce the risk of gastrointestinal adverse reactions [see Warnings and Precautions (5.2) and Adverse Reactions (6.1)] .
- After 4 weeks, increase the dosage to 5 mg injected subcutaneously once weekly. The dosage may be increased in 2.5 mg increments, after at least 4 weeks on the current dose [see Dosage and Administration (2.2)] .
- Consider treatment response and tolerability when selecting the maintenance dosage. If patients do not tolerate a maintenance dosage, consider a lower maintenance dosage.
Recommended Maintenance and Maximum Dosage
Recommended Maintenance Dosage
Weight Reduction and Long-Term Maintenance
The recommended maintenance dosage is 5 mg, 10 mg, or 15 mg, injected subcutaneously once weekly.
OSA
The recommended maintenance dosage is 10 mg or 15 mg injected subcutaneously once weekly.
Maximum Recommended Dosage
The maximum dosage of ZEPBOUND for all indications is 15 mg injected subcutaneously once weekly.
Recommendations Regarding Missed Dose
- If a dose is missed, instruct patients to administer ZEPBOUND as soon as possible within 4 days (96 hours) after the missed dose. If more than 4 days have passed, skip the missed dose and administer the next dose on the regularly scheduled day. In each case, patients can then resume their regular once weekly dosing schedule.
- The day of weekly administration can be changed, if necessary, as long as the time between the two doses is at least 3 days (72 hours).
Important Administration Instructions
- Inform patients and their caregiver(s) which ZEPBOUND presentation (e.g., vial, prefilled single-dose pen, single-patient-use KwikPen) they will receive and ensure they receive training appropriate for that specific presentation. If the prescribed ZEPBOUND presentation changes, ensure patients and caregivers receive appropriate training and instruct them to consult the Instructions for Use for the newly prescribed presentation.
- Prior to initiation, train patients and their caregiver(s) on proper injection technique for the prescribed ZEPBOUND presentation [see Instructions for Use] . After training, a patient may self-inject ZEPBOUND if the healthcare provider determines that it can be properly administered, except for the following: ZEPBOUND KwikPen is not recommended for self-administration by those who are visually impaired.
- Instruct patients using ZEPBOUND vials to use a syringe appropriate for dose administration (e.g., a 1 mL syringe capable of measuring a 0.5 mL or 0.6 mL dose) and always use a new syringe and needle for each injection.
- Inspect ZEPBOUND visually before use. It should appear clear and colorless to slightly yellow. Do not use ZEPBOUND if particulate matter or discoloration is seen.
- Administer ZEPBOUND in combination with a reduced-calorie diet and increased physical activity.
- Administer ZEPBOUND once weekly at any time of day, with or without meals.
- Inject ZEPBOUND subcutaneously in the abdomen, thigh, or another person should inject in the back of the upper arm.
- Rotate injection sites with each dose.
Source: Zepbound prescribing information (FDA label on DailyMed), revised 2026-08-28
Zepbound strengths and forms
Injection: Clear, colorless to slightly yellow solution in pre-filled single-dose pens, single-dose vials, multi-dose vials, or single-patient-use KwikPens, each available in the following strengths. The multi-dose vials and single-patient-use KwikPen each contain 4 doses:
| Single-dose Pen or Vial |
|---|
| 2.5 mg/0.5 mL |
| 5 mg/0.5 mL |
| 7.5 mg/0.5 mL |
| 10 mg/0.5 mL |
| 12.5 mg/0.5 mL |
| 15 mg/0.5 mL |
| Multi-dose Vial (4 doses per vial) | Multi-dose Vial (4 doses per vial) | Multi-dose Vial (4 doses per vial) |
|---|---|---|
| Dose per Injection | Total Strength per Total Volume | Strength per mL |
| 2.5 mg/0.6 mL | 10 mg/2.4 mL | 4.17 mg/mL |
| 5 mg/0.6 mL | 20 mg/2.4 mL | 8.33 mg/mL |
| 7.5 mg/0.6 mL | 30 mg/2.4 mL | 12.5 mg/mL |
| 10 mg/0.6 mL | 40 mg/2.4 mL | 16.7 mg/mL |
| 12.5 mg/0.6 mL | 50 mg/2.4 mL | 20.8 mg/mL |
| 15 mg/0.6 mL | 60 mg/2.4 mL | 25 mg/mL |
| Single-Patient-Use KwikPen (4 doses per KwikPen) | Single-Patient-Use KwikPen (4 doses per KwikPen) | Single-Patient-Use KwikPen (4 doses per KwikPen) |
|---|---|---|
| Dose per Injection | Total Strength per Total Volume | Strength per mL |
| 2.5 mg | 10 mg/2.4 mL | 4.17 mg/mL |
| 5 mg | 20 mg/2.4 mL | 8.33 mg/mL |
| 7.5 mg | 30 mg/2.4 mL | 12.5 mg/mL |
| 10 mg | 40 mg/2.4 mL | 16.7 mg/mL |
| 12.5 mg | 50 mg/2.4 mL | 20.8 mg/mL |
| 15 mg | 60 mg/2.4 mL | 25 mg/mL |
Source: Zepbound prescribing information (FDA label on DailyMed), revised 2026-08-28
How to store Zepbound
How Supplied
ZEPBOUND (tirzepatide) is a clear, colorless to slightly yellow solution available in cartons containing 4 pre-filled single-dose pens, 1 single-dose vial, 4 single-dose vials, 1 multi-dose vial, or 1 single-patient-use KwikPen as follows:
| Single-Dose Vial and Prefilled Pen | Single-Dose Vial and Prefilled Pen | Single-Dose Vial and Prefilled Pen | Single-Dose Vial and Prefilled Pen |
|---|---|---|---|
| Strength | 4 pack Single-dose Pen NDC | 1 pack Single-dose Vial NDC | 4 pack Single-dose Vial NDC |
| 2.5 mg/0.5 mL | 0002-2506-80 | 0002-0152-01 | 0002-0152-04 |
| 5 mg/0.5 mL | 0002-2495-80 | 0002-0243-01 | 0002-0243-04 |
| 7.5 mg/0.5 mL | 0002-2484-80 | 0002-1214-01 | 0002-1214-04 |
| 10 mg/0.5 mL | 0002-2471-80 | 0002-1340-01 | 0002-1340-04 |
| 12.5 mg/0.5 mL | 0002-2460-80 | 0002-1423-01 | 0002-1423-04 |
| 15 mg/0.5 mL | 0002-2457-80 | 0002-2002-01 | 0002-2002-04 |
| Multi-Dose Vial | Multi-Dose Vial | Multi-Dose Vial |
|---|---|---|
| Doses per Vial | Strength | 1 pack Multi-Dose Vial NDC |
| 4 doses of 2.5 mg/0.6 mL | 10 mg/2.4 mL (4.17 mg/mL) | 0002-6052-11 |
| 4 doses of 5 mg/0.6 mL | 20 mg/2.4 mL (8.33 mg/mL) | 0002-6103-11 |
| 4 doses of 7.5 mg/0.6 mL | 30 mg/2.4 mL (12.5 mg/mL) | 0002-6210-11 |
| 4 doses of 10 mg/0.6 mL | 40 mg/2.4 mL (16.7 mg/mL) | 0002-6304-11 |
| 4 doses of 12.5 mg/0.6 mL | 50 mg/2.4 mL (20.8 mg/mL) | 0002-6523-11 |
| 4 doses of 15 mg/0.6 mL | 60 mg/2.4 mL (25 mg/mL) | 0002-6612-11 |
| Single-Patient-Use KwikPen (with four weekly doses) | Single-Patient-Use KwikPen (with four weekly doses) | Single-Patient-Use KwikPen (with four weekly doses) |
|---|---|---|
| Doses per KwikPen | Strength | 1 pack Single-Patient-Use KwikPen NDC |
| 4 doses of 2.5 mg | 10 mg/2.4 mL (4.17 mg/mL) | 0002-3566-11 |
| 4 doses of 5 mg | 20 mg/2.4 mL (8.33 mg/mL) | 0002-3555-11 |
| 4 doses of 7.5 mg | 30 mg/2.4 mL (12.5 mg/mL) | 0002-3544-11 |
| 4 doses of 10 mg | 40 mg/2.4 mL (16.7 mg/mL) | 0002-3533-11 |
| 4 doses of 12.5 mg | 50 mg/2.4 mL (20.8 mg/mL) | 0002-3522-11 |
| 4 doses of 15 mg | 60 mg/2.4 mL (25 mg/mL) | 0002-3511-11 |
Storage and Handling
- Do not freeze ZEPBOUND. Do not use ZEPBOUND if frozen.
- Protect ZEPBOUND from heat and light.
- Store ZEPBOUND in the original carton to protect from light.
ZEPBOUND Single-dose Pen and Single-dose Vial
- Store ZEPBOUND single-dose pen and single-dose vial in a refrigerator at 2°C to 8°C (36°F to 46°F).
- If needed, each single-dose pen or single-dose vial can be stored unrefrigerated at temperatures not to exceed 30°C (86°F) for up to a total of 21 days.
- Discard single-dose pen and single-dose vial after a total of 21 days at room temperature.
ZEPBOUND Multi-dose Vial or Single-Patient-Use KwikPen
Unopened vial or single-patient-use KwikPen:
- Store unopened multi-dose vial or single-patient-use KwikPen in the refrigerator at 2°C to 8°C (36°F to 46°F). The unopened multi-dose vial or single-patient-use KwikPen can be used until the expiration date on the label if kept in the refrigerator.
- If stored at room temperature [up to 30°C (86°F)], throw away unopened multi-dose vial or single-patient-use KwikPen after 30 days.
After vial or single-patient-use KwikPen has been opened:
- Store opened (in-use) multi-dose vial or single-patient-use KwikPen in the original carton in the refrigerator at 2°C to 8°C (36°F to 46°F) or at room temperature [up to 30°C (86°F)].
- Throw away opened multi-dose vial or single-patient-use KwikPen after a total of 30 days at room temperature, 30 days after first use, or after taking 4 weekly doses, even if there is medicine left in it.
Source: Zepbound prescribing information (FDA label on DailyMed), revised 2026-08-28
Zepbound dosing: common questions
What should you expect in the first week of Zepbound?
From its FDA label: The recommended starting dosage of ZEPBOUND for all indications is 2.5 mg injected subcutaneously once weekly for 4 weeks. Your clinician may adjust this.
Can you skip a week of Zepbound?
Its FDA label covers a missed dose, not a planned break, so ask your prescriber before skipping one on purpose. On a missed dose it says: If a dose is missed, instruct patients to administer ZEPBOUND as soon as possible within 4 days (96 hours) after the missed dose.
What is the starting dose of Zepbound?
The recommended starting dosage of ZEPBOUND for all indications is 2.5 mg injected subcutaneously once weekly for 4 weeks.
What is the maximum or maintenance dose of Zepbound?
The maximum dosage of ZEPBOUND for all indications is 15 mg injected subcutaneously once weekly.
What if you miss a dose of Zepbound?
If a dose is missed, instruct patients to administer ZEPBOUND as soon as possible within 4 days (96 hours) after the missed dose.
How long can Zepbound stay out of the fridge?
If needed, each single-dose pen or single-dose vial can be stored unrefrigerated at temperatures not to exceed 30°C (86°F) for up to a total of 21 days.
Where do you inject Zepbound?
Inject ZEPBOUND subcutaneously in the abdomen, thigh, or another person should inject in the back of the upper arm.
When should you take Zepbound?
Administer ZEPBOUND once weekly at any time of day, with or without meals.
How do you use Zepbound?
From its FDA-approved Medication Guide: Read the Instructions for Use that comes with ZEPBOUND. Use ZEPBOUND exactly as your healthcare provider tells you to. Your healthcare provider should show you how to prepare to inject your dose of ZEPBOUND before injecting the first time. A caregiver may give you ZEPBOUND injections or you may self-inject if a healthcare provider determines that it is appropriate. Self-injection is not recommended for people who are visually impaired. Use ZEPBOUND with a reduced-calorie diet and increased physical activity. If using ZEPBOUND vials, always use a new syringe and needle for each injection. Inject ZEPBOUND under the skin (subcutaneously) of your stomach (abdomen), thigh, or another person should inject in the back of the upper arm. Do not inject ZEPBOUND into a muscle (intramuscularly) or vein (intravenously). Use ZEPBOUND 1 time each week, at any time of the day. You may change the day of the week you use ZEPBOUND as long as the time between the 2 doses is at least 3 days (72 hours). If you miss a dose of ZEPBOUND, take the missed dose as soon as possible within 4 days (96 hours) after the missed dose.
Dosing is decided by your clinician. This is the label's text for reference, not instructions for you.