GLPcompareGLPcompare
DrugsPricesCompareShortagesEvidenceSupplementsWatchlist
CompareLiraglutide vs Tirzepatide
Ingredient comparison

Liraglutide vs Tirzepatide

Compare the ingredients, then check the specific brand, formulation, and dose. Approved uses and prices vary by product.

Every cash quote was checked on or after Sep 26, 2026.Data feeds · Oct 3, 2026 UTC
OverviewDirect evidenceCash pricesTrial resultsChange comparison
Liraglutide vs Tirzepatide: overview
CompareLiraglutideTirzepatide
Brands

Liraglutide

Victoza, Saxenda

GLP-1

Tirzepatide

Mounjaro, Zepbound

GIP/GLP-1

Route & frequency

Liraglutide

Subcutaneous injection

Once daily

Tirzepatide

What was tested together

Direct comparative evidence

No direct comparative trial is included for these ingredients in our reviewed catalog. The separate trial results below do not establish which works better.

Product-specific self-pay

What the quoted price covers

Lowest tracked quotes for FDA-approved products, selected separately for each price basis. Entry prices may refer to different brands or formulations. Supply periods, eligibility, refill deadlines, and additional fees can change what you pay.

Liraglutide vs Tirzepatide: sourced cash quotes
CompareLiraglutideTirzepatide
Advertised entry price

Liraglutide

~$372/mo

Generic liraglutide 3 mg pens (Saxenda generic), GoodRx coupon

GoodRx

GoodRx coupon, lowest listed price for one carton of five 18 mg/3 mL pens

Third-party reported price

Supply period unverified; excluded from cost ranking.

Separate studies

Trial outcomes in context

Each result belongs to its own trial, population, dose, and analysis. Weight loss, HbA1c change, and adverse events may come from different studies even within one ingredient. These are study averages, not predictions of your result.

Liraglutide vs Tirzepatide: individual trial outcomes
CompareLiraglutideTirzepatide
Weight change

Liraglutide

−8% (-8.0% at 56 wks · SCALE Obesity · 3.0 mg daily (Saxenda))

-8.0% at 56 wks

SCALE Obesity

3.0 mg daily (Saxenda)

Analysis not classified; see trial methods

Check the product label

Approved uses & full records

Liraglutide

Indications depend on the brand and formulation. Read the product-specific indications and prescribing information in the full record.

514 registered ingredient studies. Count checked Oct 3, 2026. Research activity, not a measure of evidence quality.

Open full record

Tirzepatide

Indications depend on the brand and formulation. Read the product-specific indications and prescribing information in the full record.

296 registered ingredient studies. Count checked Oct 3, 2026. Research activity, not a measure of evidence quality.

Open full record
Reading the comparison

Common questions

Which costs less: Liraglutide or Tirzepatide?

Compare the named products and price conditions below. A tracked entry quote can be a different brand or formulation from the product studied in a trial. A trial-dose quote applies only to the named product and dose; neither figure is an estimate of your whole treatment cost or an insurance quote.

Do these trial results tell me which medication is best?

Direct trials compare the treatments, doses, and participants they studied. Results from separate trials differ in population, duration, dose, and analysis, so their percentages do not establish a treatment ranking. Discuss your medical history and the specific product label with a licensed clinician.

Does FDA shortage status mean my pharmacy has stock?

No. FDA shortage records describe national supply reports and covered presentations, not inventory at an individual pharmacy. Unknown status means the data cannot establish a current assessment. Confirm local stock with your pharmacy.

Other comparisons
Semaglutide vs TirzepatideSemaglutide vs LiraglutideTirzepatide vs DulaglutideTirzepatide vs ExenatideTirzepatide vs OrforglipronLiraglutide vs Dulaglutide

Automated feed checks do not constitute a clinical or editorial review. Sources & methodology

GLPcompare is an informational data platform, not a medical provider or pharmacy. Nothing here is medical advice, a diagnosis, or a recommendation to start, stop, or change any treatment. Data is aggregated from public sources and can be incomplete or out of date. Always confirm with a licensed clinician and the current FDA label.
GLPcompareGLPcompare

The live, fully-cited reference for the GLP-1 ecosystem. Every figure traces to its source. Informational only, not medical advice.

Product

  • Drugs
  • Prices
  • Compare
  • Shortages
  • Evidence
  • Supplements

Legal

  • Methodology
  • About
  • News
  • Price updates
  • Privacy Policy
  • Terms of Service
  • Support

Some outbound links on GLPcompare are referral links. If you sign up or buy through one, we may earn a commission at no extra cost to you. It never changes the price you pay or the underlying data. Partner status and commission rates contribute to offer and provider value scores and can change their order. Every partner is labeled. Value scores are not medical recommendations; a higher-ranked offer is not necessarily the lowest price or the right product for you.

© 2026 GLPcompare. All rights reserved.

Fazier

Subcutaneous injection

Once weekly

FDA shortage report

Liraglutide

In shortage

National reporting does not confirm stock at your pharmacy.

Coverage & source records

Tirzepatide

National reporting does not confirm stock at your pharmacy.

Coverage & source records
Checked Sep 30, 2026
Price conditions

GoodRx coupon, lowest listed price for one carton of five 18 mg/3 mL pens

GoodRx lists brand Saxenda separately; this is its generic liraglutide listing (Teva launched the first generic GLP-1 for weight loss in August 2025). Prices vary by pharmacy.

Tirzepatide

$299-$449/28 days

Zepbound KwikPen (multi-dose pen)

LillyDirect (Eli Lilly)

self-pay cash, by dose ($299 / $399 / $449)

28-day supply

≈ $320.36 per 30 days at this quoted rate

Checked Sep 30, 2026

Price conditions

self-pay cash, by dose ($299 / $399 / $449)

Four weekly doses per pen; pen needles must be purchased separately. $299 at 2.5 mg, $399 at 5 mg, and $449 at higher doses under the Self Pay Journey offer with a refill within 45 days.

28-day supply

At the named trial dose

Liraglutide

~$372/mo

Generic liraglutide 3 mg pens (Saxenda generic), GoodRx coupon

At 3 mg

GoodRx

Published price at 3 mg

Third-party reported price

Supply period unverified; excluded from cost ranking.

Checked Sep 30, 2026

Price conditions

Published price at 3 mg

GoodRx lists brand Saxenda separately; this is its generic liraglutide listing (Teva launched the first generic GLP-1 for weight loss in August 2025). Prices vary by pharmacy.

Five pens hold 90 mg: 30 days at the 3 mg daily dose.

Tirzepatide

$449/28 days

Zepbound KwikPen (multi-dose pen)

At 15 mg

LillyDirect (Eli Lilly)

Published price at 15 mg

28-day supply

≈ $481.07 per 30 days at this quoted rate

Checked Sep 30, 2026

Price conditions

Published price at 15 mg

Four weekly doses per pen; pen needles must be purchased separately. $299 at 2.5 mg, $399 at 5 mg, and $449 at higher doses under the Self Pay Journey offer with a refill within 45 days.

Self Pay Journey price for 7.5-15 mg with a refill within 45 days; otherwise $499 (7.5 mg) or $699 (10-15 mg). Pen needles cost extra.

28-day supply

Explore product prices

Liraglutide

All Liraglutide offers

Tirzepatide

All Tirzepatide offers

USD self-pay, not insurance or pharmacy acquisition cost. A trial dose is not a personal dosing recommendation. Compounded offers are shown separately in the offer browser and are not FDA-approved.

Tirzepatide

−20.9% (-20.9% at 72 wks · SURMOUNT-1 · 15 mg weekly (Zepbound))

-20.9% at 72 wks

SURMOUNT-1

15 mg weekly (Zepbound)

Accounts for treatment discontinuation

Study context

SURMOUNT-1 studied adults with obesity or overweight without diabetes. This result belongs to the 15 mg arm and the treatment-regimen analysis; other doses and analyses have different results.

HbA1c change (percentage points)

Liraglutide

−1.3 pp (-1.3% at 56 wks · SCALE Diabetes · HbA1c change in percentage points)

-1.3 percentage points at 56 wks

SCALE Diabetes

Tirzepatide

−2.3 pp (-2.3% at 40 wks · SURPASS-2 · HbA1c change in percentage points)

-2.3 percentage points at 40 wks

SURPASS-2
Study context

SURMOUNT-1 studied adults with obesity or overweight without diabetes. This result belongs to the 15 mg arm and the treatment-regimen analysis; other doses and analyses have different results.

Adverse events

Liraglutide

Stopped treatment for adverse events

9.8% (9.8% vs 4.3% placebo (3.0 mg) · FDA Saxenda label, pooled 3.0 mg obesity trials (SCALE))

Reported nausea

39.3% (Nausea in the drug arm · FDA Saxenda label, pooled 3.0 mg obesity trials (SCALE))

FDA Saxenda label, pooled 3.0 mg obesity trials (SCALE)

from the FDA Saxenda adverse-reactions table (the SCALE Obesity trial paper is paywalled); essentially identical to the trial's own ~9.9% / ~40% figures

Tirzepatide

Stopped treatment for adverse events

6.2% (6.2% vs 2.6% placebo (15 mg) · SURMOUNT-1 (15 mg, 72 wks, obesity))

Reported nausea

31% (Nausea in the drug arm · SURMOUNT-1 (15 mg, 72 wks, obesity))

SURMOUNT-1 (15 mg, 72 wks, obesity)