Rybelsus and Ozempic tablets dosage
Starting Dosage (Initiation Phase) (Days 1 to 30): The recommended starting dosage is 3 mg orally once daily (this dosage is not effective for glycemic control).
Word for word from the FDA label on DailyMed (Novo Nordisk Pharmaceutical Industries, LP), revised , version 14. Read every day: a new FDA version updates this page by itself.
Rybelsus and Ozempic tablets dosage chart
The soonest the label's schedule allows. A clinician can go slower.
| Rybelsus | Dose |
|---|---|
| Days 1 to 30 | 3 mg |
| Days 31 to 60 | 7 mg |
| Day 61 or later | 14 mgif more control is needed |
| Ozempic tablets | Dose |
|---|---|
| Days 1 to 30 | 1.5 mg |
| Days 31 to 60 | 4 mg |
| Day 61 or later | 9 mgif more control is needed |
Rybelsus and Ozempic tablets dosing and administration
Important Administration Instructions
- RYBELSUS and OZEMPIC tablets are not substitutable on a mg-to-mg basis.
- Take one RYBELSUS or OZEMPIC tablet orally once daily on an empty stomach in the morning with water (up to 4 ounces of water). Do not take RYBELSUS or OZEMPIC tablets with other liquids besides water [see Clinical Pharmacology ( 12.3 )] .
- Do not take more than one tablet per day.
- Swallow tablets whole. Do not split, crush, chew or dissolve in any solution.
- After taking RYBELSUS or OZEMPIC tablets, wait at least 30 minutes before eating food, drinking beverages or taking other oral medications [see Clinical Pharmacology ( 12.3 )] .
- If a dose is missed, skip the missed dose and take the next dose the following day.
Recommended Starting, Escalation and Maintenance Dosage of RYBELSUS and OZEMPIC Tablets
RYBELSUS: Recommended Dosage
Follow the RYBELSUS starting, escalation, and maintenance dosage described below to reduce the risk of gastrointestinal (GI) adverse reactions [see Warnings and Precautions ( 5.6 ), Adverse Reactions ( 6.1 )] :
- Starting Dosage (Initiation Phase) (Days 1 to 30): The recommended starting dosage is 3 mg orally once daily (this dosage is not effective for glycemic control).
- Escalation and Maintenance Dosage (Days 31 and beyond):
- Days 31 to 60: Increase the dosage to 7 mg orally once daily.
- On Day 61 or thereafter, if:
- No additional glycemic control is needed, maintain the dosage at 7 mg orally once daily.
- Additional glycemic control is needed, increase the dosage to 14 mg orally once daily.
OZEMPIC Tablets: Recommended Dosage
Follow the OZEMPIC tablets starting, escalation, and maintenance dosage described below to reduce the risk of GI adverse reactions [see Warnings and Precautions ( 5.6 ), Adverse Reactions ( 6.1 )] :
- Starting Dosage (Initiation Phase) (Days 1 through 30): The recommended starting dosage is 1.5 mg orally once daily (this dosage is not effective for glycemic control).
- Escalation and Maintenance Dosage (Days 31 and beyond):
- Days 31 to 60: Increase the dosage to 4 mg orally once daily.
- On Day 61 or thereafter, if:
- No additional glycemic control is needed, maintain the dosage at 4 mg orally once daily.
- Additional glycemic control is needed, increase the dosage to 9 mg orally once daily.
Switching Between RYBELSUS and OZEMPIC Tablets
- Do not switch between RYBELSUS and OZEMPIC tablets during the initiation phase (Days 1 to 30) [see Dosage and Administration ( 2.2 )] .
- After 30 days of RYBELSUS or OZEMPIC tablet treatment (after the initiation phase) [see Dosage and Administration ( 2.2 )] , patients may switch between RYBELSUS and OZEMPIC tablet products (see Table 1).
- When switching between RYBELSUS and OZEMPIC tablets, initiate the other semaglutide tablet product the day after discontinuing the previous semaglutide tablet product.
Table 1. Switching Between Escalation or Maintenance Dosage of RYBELSUS and OZEMPIC Tablets
| RYBELSUS | OZEMPIC Tablets |
|---|---|
| 7 mg orally once daily | 4 mg orally once daily |
| 14 mg orally once daily | 9 mg orally once daily |
Switching from OZEMPIC Injection to RYBELSUS or OZEMPIC Tablets
Switching from OZEMPIC Injection to RYBELSUS Tablets
- Patients taking the 0.5 mg dose of OZEMPIC injection may switch to RYBELSUS tablets.
- One week after discontinuing 0.5 mg of subcutaneous OZEMPIC injection, start 7 mg or 14 mg of RYBELSUS orally once daily.
Switching from OZEMPIC Injection to OZEMPIC Tablets
- Patients taking the 0.5 mg dose of OZEMPIC injection may switch to OZEMPIC tablets.
- One week after discontinuing 0.5 mg of subcutaneous OZEMPIC injection, start 4 mg or 9 mg of OZEMPIC tablets orally once daily.
Source: Rybelsus and Ozempic tablets prescribing information (FDA label on DailyMed), revised 2026-01-30
Rybelsus and Ozempic tablets strengths and forms
RYBELSUS (semaglutide) tablets are available as:
- 3 mg: white to light yellow, oval shaped debossed with “3” on one side and “novo” on the other side.
- 7 mg: white to light yellow, oval shaped debossed with “7” on one side and “novo” on the other side.
- 14 mg: white to light yellow, oval shaped debossed with “14” on one side and “novo” on the other side.
OZEMPIC (semaglutide) tablets are available as:
- 1.5 mg: white to light yellow, round shaped debossed with “1.5” on one side and “novo” on the other side.
- 4 mg: white to light yellow, round shaped debossed with “4” on one side and “novo” on the other side.
- 9 mg: white to light yellow, round shaped debossed with “9” on one side and “novo” on the other side.
Source: Rybelsus and Ozempic tablets prescribing information (FDA label on DailyMed), revised 2026-01-30
How to store Rybelsus and Ozempic tablets
How Supplied
RYBELSUS strengths are available as follows:
| Tablet Strength | Description | Package Configuration | NDC Number |
|---|---|---|---|
| 3 mg | White to light yellow, oval shaped debossed with “3” on one side and “novo” on the other side | Bottle of 30 tablets | 0169-4303-30 |
| 7 mg | White to light yellow, oval shaped debossed with “7” on one side and “novo” on the other side | Bottle of 30 tablets | 0169-4307-30 |
| 14 mg | White to light yellow, oval shaped debossed with “14” on one side and “novo” on the other side | Bottle of 30 tablets | 0169-4314-30 |
OZEMPIC tablet strengths are available as follows:
| Tablet Strength | Description | Package Configuration | NDC Number |
|---|---|---|---|
| 1.5 mg | White to light yellow, round shaped debossed with “1.5” on one side and “novo” on the other side | Bottle of 30 tablets | 0169-1715-30 |
| 4 mg | White to light yellow, round shaped debossed with “4” on one side and “novo” on the other side | Bottle of 30 tablets | 0169-1704-30 |
| 9 mg | White to light yellow, round shaped debossed with “9” on one side and “novo” on the other side | Bottle of 30 tablets | 0169-1709-30 |
Storage and Handling
Store RYBELSUS and OZEMPIC tablets at 20°C to 25°C (68°F to 77°F); excursions permitted to 15°C to 30°C (59°F to 86°F) [see USP Controlled Room Temperature]. Store and dispense in the original bottle.
Store tablets in the original bottle until use to protect tablets from moisture. Store product in a dry place away from moisture.
Source: Rybelsus and Ozempic tablets prescribing information (FDA label on DailyMed), revised 2026-01-30
Rybelsus and Ozempic tablets dosing: common questions
What should you expect in the first week of Rybelsus and Ozempic tablets?
From its FDA label: Starting Dosage (Initiation Phase) (Days 1 to 30): The recommended starting dosage is 3 mg orally once daily (this dosage is not effective for glycemic control). Your clinician may adjust this.
Can you drink coffee after taking Rybelsus and Ozempic tablets?
Not straight away. Its FDA label says: After taking RYBELSUS or OZEMPIC tablets, wait at least 30 minutes before eating food, drinking beverages or taking other oral medications.
What is the starting dose of Rybelsus and Ozempic tablets?
Starting Dosage (Initiation Phase) (Days 1 to 30): The recommended starting dosage is 3 mg orally once daily (this dosage is not effective for glycemic control).
What if you miss a dose of Rybelsus and Ozempic tablets?
If a dose is missed, skip the missed dose and take the next dose the following day.
When should you take Rybelsus and Ozempic tablets?
Take one RYBELSUS or OZEMPIC tablet orally once daily on an empty stomach in the morning with water (up to 4 ounces of water). After taking RYBELSUS or OZEMPIC tablets, wait at least 30 minutes before eating food, drinking beverages or taking other oral medications.
How do you use Rybelsus and Ozempic tablets?
From its FDA-approved Medication Guide: Take RYBELSUS or OZEMPIC tablets exactly as your healthcare provider tells you to. Take 1 RYBELSUS or OZEMPIC tablet by mouth on an empty stomach in the morning with water (no more than 4 ounces). Do not take RYBELSUS or OZEMPIC tablets with any other liquids besides water. Do not split, crush, chew, or dissolve RYBELSUS or OZEMPIC tablets. Swallow RYBELSUS or OZEMPIC tablets whole. After 30 minutes, you can eat, drink, or take other oral medicines. Do not take more than 1 RYBELSUS or OZEMPIC tablet each day. If you miss a dose of RYBELSUS or OZEMPIC tablets, skip the missed dose and go back to your regular schedule. If you take too much RYBELSUS or OZEMPIC tablets, call your healthcare provider or Poison Help line at 1-800-222-1222, or go to the nearest hospital emergency room right away. Advice is also available online at poisonhelp.org. Your dose of RYBELSUS or OZEMPIC tablets and other diabetes medicines may need to change because of: change in level of physical activity or exercise, weight gain or loss, increased stress, illness, change in diet, fever, trauma, infection, surgery or because of other medicines you take.
Dosing is decided by your clinician. This is the label's text for reference, not instructions for you.