Ozempic dosage
Initiate OZEMPIC with a dosage of 0.25 mg injected subcutaneously once weekly for 4 weeks. The maximum recommended dosage is 2 mg once weekly.
Word for word from the FDA label on DailyMed (Novo Nordisk Pharmaceutical Industries, LP), revised , version 20. Read every day: a new FDA version updates this page by itself.
Ozempic dosage chart
The soonest the label's schedule allows. A clinician can go slower.
| Injection | Dose |
|---|---|
| Weeks 1 to 4 | 0.25 mg |
| Weeks 5 to 8 | 0.5 mg |
| Week 9 or later | 1 mgif more control is needed |
| Week 13 or later | 2 mgif more control is needed |
Ozempic dosing and administration
Important Administration Instructions
- Inspect OZEMPIC visually before use. It should appear clear and colorless. Do not use OZEMPIC if particulate matter and coloration is seen.
- Administer OZEMPIC once weekly, on the same day each week, at any time of the day, with or without meals.
- Inject OZEMPIC subcutaneously in the abdomen, thigh, or upper arm. Instruct patients to use a different injection site each week when injecting in the same body region.
- When using OZEMPIC with insulin, instruct patients to administer as separate injections and to never mix the products. It is acceptable to inject OZEMPIC and insulin in the same body region, but the injections should not be adjacent to each other.
- The day of weekly administration can be changed if necessary as long as the time between two doses is at least 2 days (>48 hours).
- If a dose is missed, administer OZEMPIC as soon as possible within 5 days after the missed dose. If more than 5 days have passed, skip the missed dose and administer the next dose on the regularly scheduled day. In each case, patients can then resume their regular once-weekly dosing schedule.
Recommended Dosage
Recommended Initiation Dosage
Initiate OZEMPIC with a dosage of 0.25 mg injected subcutaneously once weekly for 4 weeks. Follow the dosage escalation below to reduce the risk of gastrointestinal adverse reactions [see Warnings and Precautions (5.7), Adverse Reactions (6.1)].
After 4 weeks on the 0.25 mg dosage, increase the dosage to 0.5 mg once weekly.
Recommended Maintenance and Maximum Dosages for Glycemic Control
The recommended maintenance dosage is 0.5 mg, 1 mg, or 2 mg, injected subcutaneously once weekly, based on glycemic control.
If additional glycemic control is needed after at least 4 weeks on the:
- 0.5 mg dosage, the dosage may be increased to 1 mg once weekly.
- 1 mg dosage, the dosage may be increased to 2 mg once weekly.
The maximum recommended dosage is 2 mg once weekly.
Recommended Maintenance Dosage in Patients with Type 2 Diabetes Mellitus and Chronic Kidney Disease
Increase the dosage to the maintenance dosage, 1 mg once weekly, after at least 4 weeks on the 0.5 mg dosage.
Source: Ozempic prescribing information (FDA label on DailyMed), revised 2026-06-01
Ozempic strengths and forms
Injection: clear, colorless solution available as follows:
| Single-Patient-Use Pens (with multiple weekly doses) | Single-Patient-Use Pens (with multiple weekly doses) | Single-Patient-Use Pens (with multiple weekly doses) |
|---|---|---|
| Dose per Injection | Total Strength per Total Volume | Strength per mL |
| 0.25 mg 0.5 mg | 2 mg / 3 mL | 0.68 mg/mL |
| 1 mg | 4 mg / 3 mL | 1.34 mg/mL |
| 2 mg | 8 mg / 3 mL | 2.68 mg/mL |
| Single-Dose Prefilled Syringes | Single-Dose Prefilled Syringes |
|---|---|
| Dose per Injection | Total Strength per Total Volume |
| 0.25 mg | 0.25 mg / 0.5 mL |
| 0.5 mg | 0.5 mg / 0.5 mL |
| 1 mg | 1 mg / 0.5 mL |
Source: Ozempic prescribing information (FDA label on DailyMed), revised 2026-06-01
How to store Ozempic
How Supplied Single-patient-use pens (with multiple weekly doses): Injection: clear, colorless solution of 0.68 mg/mL, 1.34 mg/mL or 2.68 mg/mL of semaglutide available in the following packaging configurations:
| Single-Patient-Use Pens (with multiple weekly doses) | Single-Patient-Use Pens (with multiple weekly doses) | Single-Patient-Use Pens (with multiple weekly doses) | Single-Patient-Use Pens (with multiple weekly doses) | Single-Patient-Use Pens (with multiple weekly doses) | Single-Patient-Use Pens (with multiple weekly doses) |
|---|---|---|---|---|---|
| Dose per Injection | Use For | Total Strength per Total Volume | Doses per Pen | Carton Contents | NDC |
| 0.25 mg 0.5 mg | Initiation Maintenance | 2 mg/3 mL | 4 doses of 0.25 mg and 2 doses of 0.5 mg or 4 doses of 0.5 mg | 1 pen 6 NovoFine Plus needles | 0169-4181-13 |
| 1 mg | Maintenance | 4 mg/3 mL | 4 doses of 1 mg | 1 pen 4 NovoFine Plus needles | 0169-4130-13 |
| 2 mg | Maintenance | 8 mg/3 mL | 4 doses of 2 mg | 1 pen 4 NovoFine Plus needles | 0169-4772-12 |
Each OZEMPIC multi-dose pen is for use by a single patient. An OZEMPIC pen must never be shared between patients, even if the needle is changed [see Warnings and Precautions (5.4)] .
Single-dose prefilled syringes:
Injection: clear, colorless solution of 0.5 mg/mL, 1 mg/mL, 2 mg/mL of semaglutide available in the following packaging configurations:
| Single-Dose Prefilled Syringes | Single-Dose Prefilled Syringes | Single-Dose Prefilled Syringes | Single-Dose Prefilled Syringes | Single-Dose Prefilled Syringes | Single-Dose Prefilled Syringes |
|---|---|---|---|---|---|
| Dose per Injection | Use For | Total Strength per Total Volume | Doses per Syringe | Carton Contents | NDC |
| 0.25 mg | Initiation | 0.25 mg / 0.5 mL | Single-dose | 4 Prefilled Syringes | 0169-1302-14 |
| 0.5 mg | Maintenance | 0.5 mg / 0.5 mL | Single-dose | 4 Prefilled Syringes | 0169-1305-14 |
| 1 mg | Maintenance | 1 mg / 0.5 mL | Single-dose | 4 Prefilled Syringes | 0169-1310-14 |
Recommended Storage Conditions for OZEMPIC
Single-patient-use pens (with multiple weekly doses):
Prior to first use, the OZEMPIC pen should be stored in a refrigerator between 2°C to 8°C (36°F to 46°F). Do not store in the freezer or directly adjacent to the refrigerator cooling element. Do not freeze OZEMPIC and do not use OZEMPIC if it has been frozen. OZEMPIC must be kept in the original carton until time of administration.
After first use of the OZEMPIC pen, the pen can be stored for 56 days at controlled room temperature 15°C to 30°C (59°F to 86°F) or in a refrigerator 2°C to 8°C (36°F to 46°F). Do not freeze. Keep the pen cap on when not in use. OZEMPIC should be protected from excessive heat and sunlight.
Always remove and safely discard the needle after each injection and store the OZEMPIC pen without an injection needle attached. Always use a new needle for each injection.
| Single-Patient-Use Pens (with multiple weekly doses) | Single-Patient-Use Pens (with multiple weekly doses) | Single-Patient-Use Pens (with multiple weekly doses) |
|---|---|---|
| Prior to first use | After first use | After first use |
| Refrigerated 2°C to 8°C (36°F to 46°F) | Room Temperature 15°C to 30°C (59°F to 86°F) | Refrigerated 2°C to 8°C (36°F to 46°F) |
| Until expiration date | 56 days | 56 days |
Single-dose prefilled syringes: Store the OZEMPIC prefilled syringe refrigerated at 2°C to 8°C (36°F to 46°F). If needed, the syringe can be kept from 8°C to 30°C (46°F to 86°F) up to 28 days. Do not freeze OZEMPIC and do not use OZEMPIC if it has been frozen. Protect OZEMPIC from light. OZEMPIC must be kept in the original carton until time of administration. Discard the OZEMPIC syringe after use.
| Single-Dose Prefilled Syringes | Single-Dose Prefilled Syringes |
|---|---|
| Refrigerated 2°C to 8°C (36°F to 46°F) | Room Temperature 8°C to 30°C (46°F to 86°F) |
| Until expiration date | 28 days |
Source: Ozempic prescribing information (FDA label on DailyMed), revised 2026-06-01
Ozempic dosing: common questions
What should you expect in the first week of Ozempic?
From its FDA label: Initiate OZEMPIC with a dosage of 0.25 mg injected subcutaneously once weekly for 4 weeks. Your clinician may adjust this.
Can you skip a week of Ozempic?
Its FDA label covers a missed dose, not a planned break, so ask your prescriber before skipping one on purpose. On a missed dose it says: If a dose is missed, administer OZEMPIC as soon as possible within 5 days after the missed dose.
What is the starting dose of Ozempic?
Initiate OZEMPIC with a dosage of 0.25 mg injected subcutaneously once weekly for 4 weeks.
What is the maximum or maintenance dose of Ozempic?
The maximum recommended dosage is 2 mg once weekly.
What if you miss a dose of Ozempic?
If a dose is missed, administer OZEMPIC as soon as possible within 5 days after the missed dose.
How long can Ozempic stay out of the fridge?
After first use of the OZEMPIC pen, the pen can be stored for 56 days at controlled room temperature 15°C to 30°C (59°F to 86°F) or in a refrigerator 2°C to 8°C (36°F to 46°F).
Where do you inject Ozempic?
Inject OZEMPIC subcutaneously in the abdomen, thigh, or upper arm.
When should you take Ozempic?
Administer OZEMPIC once weekly, on the same day each week, at any time of the day, with or without meals.
How do you use Ozempic?
From its FDA-approved Medication Guide: Read the Instructions for Use that comes with OZEMPIC. Use OZEMPIC exactly as your healthcare provider tells you to. Your healthcare provider should show you how to use OZEMPIC before you use it for the first time. OZEMPIC is injected under the skin (subcutaneously) of your stomach (abdomen), thigh, or upper arm. Do not inject OZEMPIC into a muscle (intramuscularly) or vein (intravenously). Use OZEMPIC 1 time each week, on the same day each week, at any time of the day. You may change the day of the week you use OZEMPIC as long as your last dose was given 2 or more days before. If you miss a dose of OZEMPIC, take the missed dose as soon as possible within 5 days after the missed dose. If more than 5 days have passed, skip the missed dose and take your next dose on the regularly scheduled day. OZEMPIC may be taken with or without food. Do not mix insulin and OZEMPIC together in the same injection. You may give an injection of OZEMPIC and insulin in the same body area (such as your stomach area), but not right next to each other.
Dosing is decided by your clinician. This is the label's text for reference, not instructions for you.