Wegovy
- Semaglutide lowers body weight with greater fat mass loss than lean mass loss.
Label revised Jun 18, 2026. DailyMed
From each FDA label
Do GLP-1s cause muscle loss?
Wegovy, Zepbound and Foundayo say the weight lost is more fat than lean mass, which also means some lean mass is lost. The other labels do not say.
Read from each manufacturer's FDA label on DailyMed. The newest revision saying anything on this is Aug 28, 2026.
Word for word
What each label says about muscle loss
Sentences from each label, in its own words. Only cross-references are removed.
Zepbound
- Tirzepatide lowers body weight with greater fat mass loss than lean mass loss.
Label revised Aug 28, 2026. DailyMed
Foundayo
- Foundayo reduces body weight, with greater fat mass loss than lean mass loss.
Label revised Jul 29, 2026. DailyMed
Ozempic, Rybelsus and Ozempic tablets, Mounjaro, Trulicity, Saxenda, Victoza, Byetta: no finding on this in the sections read here.
Updated automatically
Latest FDA label updates
- FDA labelFDA label updated: Zepbound (Eli Lilly and Company), effective 2026-08-28
- FDA labelFDA label updated: Mounjaro (Eli Lilly and Company), effective 2026-08-27
- FDA labelFDA label updated: Foundayo (Eli Lilly and Company), effective 2026-07-29
- FDA labelFDA label updated: Liraglutide (Meitheal Pharmaceuticals Inc.), effective 2026-07-27
- FDA labelFDA label updated: Liraglutide (NorthStar Rx LLC), effective 2026-06-24
Written from each source's own record as it changes. Every change on GLPcompare
Questions
Muscle loss on a GLP-1: common questions
Does Wegovy cause muscle loss?
Its FDA label: Semaglutide lowers body weight with greater fat mass loss than lean mass loss.
Does Zepbound cause muscle loss?
Its FDA label: Tirzepatide lowers body weight with greater fat mass loss than lean mass loss.
Does Foundayo cause muscle loss?
Its FDA label: Foundayo reduces body weight, with greater fat mass loss than lean mass loss.
Other side effects
- Nausea
- Vomiting
- Diarrhea
- Constipation
- Stomach pain
- Indigestion
- Acid reflux
- Burping
- Gas
- Bloating
- Fatigue
- Headache
- Dizziness
- Hair loss
- Injection site reactions
- Skin sensitivity and tingling
- Taste changes
- Pancreatitis
- Gallbladder problems
- Low blood sugar
- Kidney problems
- Gastroparesis and severe stomach problems
- Allergic reactions
- Thyroid cancer
- Eye problems
- Fast heart rate
- Aspiration under anesthesia
- Depression and suicidal thoughts
- Birth control
- Drug interactions
- Metformin
- Pregnancy
- Breastfeeding
Trial rates describe groups, not what one person will feel. Talk to your clinician before starting, stopping or changing a medicine.
GLPcompare is an informational data platform, not a medical provider or pharmacy. Nothing here is medical advice, a diagnosis, or a recommendation to start, stop, or change any treatment. Data is aggregated from public sources and can be incomplete or out of date. Always confirm with a licensed clinician and the current FDA label.