Ozempic
- Other adverse reactions with a frequency of >0.4% were associated with Ozempic include fatigue, dysgeusia and dizziness.
Label revised Jun 1, 2026. DailyMed
From each FDA label
Do GLP-1s make you tired?
Fatigue is in the main trial table of 5 labels. The highest rate printed is 11% on Wegovy 2.4 mg (5% on placebo) and the lowest 5.6% on Trulicity 1.5 mg (2.6% on placebo). Separate trials, so not a ranking.
Read from each manufacturer's FDA label on DailyMed. The newest revision saying anything on this is Aug 27, 2026.
Rate against placebo
How often fatigue happened in each medicine's trials
At the highest dose in each label's main table. Separate trials with different people, so compare each rate with its own placebo group, not with another medicine.
Word for word
What each label says about fatigue
Sentences from each label's warnings and side effect sections. Only cross-references are removed.
Mounjaro
- In a CV outcomes trial of 6,647 adults with type 2 diabetes mellitus and established CV disease exposed to Mounjaro, adverse reactions reported with Mounjaro were similar with the exception of dysesthesia (0.7%), decreased appetite (17%), constipation (13%), vomiting (12%), abdominal pain (10%), and fatigue (10%).
Label revised Aug 27, 2026. DailyMed
Saxenda
- Events of asthenia, fatigue, malaise, dysgeusia and dizziness were mainly reported within the first 12 weeks of treatment with Saxenda and were often co-reported with gastrointestinal events such as nausea, vomiting, and diarrhea.
Label revised Feb 25, 2026. DailyMed
Wegovy, Rybelsus and Ozempic tablets, Zepbound, Foundayo, Trulicity, Victoza, Byetta: no finding on this in the sections read here.
Not from trials
Reports to FDA about fatigue
Counts of voluntary reports from patients and doctors. They cannot show that a medicine caused anything and cannot give a rate, and a brand used by more people draws more reports.
| Medicine | Reports naming | All reports on it |
|---|---|---|
| Zepbound | Fatigue: 2,973 · Weakness: 851 | 80,835 |
| Ozempic | Fatigue: 2,967 · Weakness: 1,864 | 70,863 |
| Mounjaro | Fatigue: 2,597 · Weakness: 1,060 | 97,440 |
| Trulicity | Fatigue: 2,421 · Weakness: 1,299 | 87,279 |
| Byetta | Fatigue: 1,762 · Weakness: 1,545 | 52,087 |
| Victoza | Fatigue: 1,305 · Weakness: 851 | 41,462 |
| Wegovy | Fatigue: 1,116 · Weakness: 385 | 25,993 |
| Saxenda | Fatigue: 325 · Weakness: 125 | 7,270 |
| Rybelsus and Ozempic tablets | Fatigue: 313 · Weakness: 242 | 7,758 |
| Foundayo | Fatigue: 226 · Weakness: 52 | 3,050 |
Counted through openFDA from FDA's Adverse Event Reporting System, refreshed weekly. One report can name several terms.
Updated automatically
Latest FDA label updates
- FDA labelFDA label updated: Zepbound (Eli Lilly and Company), effective 2026-08-28
- FDA labelFDA label updated: Mounjaro (Eli Lilly and Company), effective 2026-08-27
- FDA labelFDA label updated: Foundayo (Eli Lilly and Company), effective 2026-07-29
- FDA labelFDA label updated: Liraglutide (Meitheal Pharmaceuticals Inc.), effective 2026-07-27
- FDA labelFDA label updated: Liraglutide (NorthStar Rx LLC), effective 2026-06-24
Written from each source's own record as it changes. Every change on GLPcompare
Questions
Fatigue on a GLP-1: common questions
Which GLP-1 causes the most fatigue?
No trial here ranks them. By the rates each label prints, Wegovy 2.4 mg is highest at 11% (placebo 5%) and Trulicity 1.5 mg lowest at 5.6% (placebo 2.6%). These come from separate trials with different people and doses, so compare each to its own placebo group.
Does Wegovy make you tired?
In its FDA label, 11% of people taking Wegovy 2.4 mg reported fatigue, against 5% on placebo.
Does Foundayo make you tired?
In its FDA label, 9% of people taking Foundayo 17.2 mg reported fatigue, against 4% on placebo.
Does Saxenda make you tired?
In its FDA label, 7.5% of people taking Saxenda 3 mg reported fatigue, against 4.6% on placebo.
Does Zepbound make you tired?
In its FDA label, 7% of people taking Zepbound 15 mg reported fatigue, against 3% on placebo.
Does Trulicity make you tired?
In its FDA label, 5.6% of people taking Trulicity 1.5 mg reported fatigue, against 2.6% on placebo.
How long does fatigue last on a GLP-1?
Labels describe when it happens, not how many days it lasts. Saxenda: "Events of asthenia, fatigue, malaise, dysgeusia and dizziness were mainly reported within the first 12 weeks of treatment with Saxenda and were often co-reported with gastrointestinal events such as nausea, vomiting, and diarrhea."
Other side effects
- Nausea
- Vomiting
- Diarrhea
- Constipation
- Stomach pain
- Indigestion
- Acid reflux
- Burping
- Gas
- Bloating
- Headache
- Dizziness
- Hair loss
- Injection site reactions
- Skin sensitivity and tingling
- Taste changes
- Muscle loss
- Pancreatitis
- Gallbladder problems
- Low blood sugar
- Kidney problems
- Gastroparesis and severe stomach problems
- Allergic reactions
- Thyroid cancer
- Eye problems
- Fast heart rate
- Aspiration under anesthesia
- Depression and suicidal thoughts
- Birth control
- Drug interactions
- Metformin
- Pregnancy
- Breastfeeding
Trial rates describe groups, not what one person will feel. Talk to your clinician before starting, stopping or changing a medicine.
GLPcompare is an informational data platform, not a medical provider or pharmacy. Nothing here is medical advice, a diagnosis, or a recommendation to start, stop, or change any treatment. Data is aggregated from public sources and can be incomplete or out of date. Always confirm with a licensed clinician and the current FDA label.