From each FDA label

Do GLP-1s raise your heart rate?

2 of the 10 current GLP-1 labels carry a warning on a faster heart rate. Wegovy's label says: "Treatment with Wegovy was associated with increases in resting heart rate."

Read from each manufacturer's FDA label on DailyMed. The newest revision saying anything on this is Aug 28, 2026.

Word for word

What each label says about a faster heart rate

Sentences from each label's warnings and side effect sections. Only cross-references are removed.

Wegovy · Warning: Heart Rate Increase

  • Treatment with Wegovy was associated with increases in resting heart rate.
  • Mean increases in resting heart rate of 1 to 4 beats per minute (bpm) were observed in Wegovy injection-treated adult patients compared to placebo in clinical trials for weight reduction.
  • More adult patients treated with Wegovy injection compared with placebo had maximum changes from baseline at any visit of 10 to 19 bpm (41% versus 34%, respectively) and 20 bpm or more (26% versus 16%, respectively).
  • In a clinical trial for weight reduction in pediatric patients aged 12 years and older with normal baseline heart rate, more patients treated with Wegovy compared to placebo had maximum changes in heart rate of 20 bpm or more (54% versus 39%).

Label revised Jun 18, 2026. DailyMed

Ozempic

  • In placebo-controlled trials, Ozempic 0.5 mg and 1 mg resulted in a mean increase in heart rate of 2 to 3 beats per minute. There was a mean decrease in heart rate of 0.3 beats per minute in placebo-treated patients.

Label revised Jun 1, 2026. DailyMed

Rybelsus and Ozempic tablets

  • Increases in Heart Rate: In placebo-controlled trials, semaglutide tablets 7 mg and 14 mg tablets resulted in a mean increase in heart rate of 1 to 3 beats per minute. There was no change in heart rate in placebo-treated patients.

Label revised Jan 30, 2026. DailyMed

Zepbound

  • In a pool of Study 1 and 2, treatment with Zepbound resulted in a mean increase in heart rate of 1 to 3 beats per minute compared to no increase in placebo-treated patients.

Label revised Aug 28, 2026. DailyMed

Mounjaro

  • In the pool of placebo-controlled trials in adults, treatment with Mounjaro resulted in a mean increase in heart rate of 2 to 4 beats per minute compared to a mean increase of 1 beat per minute in placebo-treated patients.
  • Episodes of sinus tachycardia, associated with a concomitant increase from baseline in heart rate of ≥15 beats per minute, also were reported in 4.3%, 4.6%, 5.9% and 10% of subjects treated with placebo, Mounjaro 5 mg, 10 mg, and 15 mg, respectively.
  • The clinical relevance of heart rate increases is uncertain.

Label revised Aug 27, 2026. DailyMed

Foundayo

  • In a pool of Trials 1 and 2, tachycardia (tachycardia, heart rate increased, and sinus tachycardia) was reported in 3% of patients treated with Foundayo and 0.9% receiving placebo.
  • Treatment with Foundayo resulted in a mean increase in heart rate of 4 to 5 beats per minute from baseline compared to 0.5 beat per minute with placebo.

Label revised Jul 29, 2026. DailyMed

Trulicity

  • In adult patients, Trulicity 0.75 mg and 1.5 mg resulted in a mean increase in heart rate (HR) of 2-4 beats per minute (bpm).
  • Sinus tachycardia was reported in 3.0%, 2.8%, and 5.6% of patients treated with placebo, Trulicity 0.75 mg and Trulicity 1.5 mg, respectively.
  • Persistence of sinus tachycardia (reported at more than 2 visits) was reported in 0.2%, 0.4% and 1.6% of patients treated with placebo, Trulicity 0.75 mg and Trulicity 1.5 mg, respectively.
  • Episodes of sinus tachycardia, associated with a concomitant increase from baseline in heart rate of ≥15 beats per minute, were reported in 0.7%, 1.3% and 2.2% of patients treated with placebo, Trulicity 0.75 mg and Trulicity 1.5 mg, respectively.

Label revised Jun 16, 2026. DailyMed

Saxenda · Warning: Heart Rate Increase

  • Mean increases in resting heart rate of 2 to 3 beats per minute (bpm) were observed with routine clinical monitoring in Saxenda-treated adult patients compared to placebo in clinical trials.
  • More patients treated with Saxenda, compared with placebo, had changes from baseline at two consecutive visits of more than 10 bpm (34% versus 19%, respectively) and 20 bpm (5% versus 2%, respectively).
  • At least one resting heart rate exceeding 100 bpm was recorded for 6% of Saxenda-treated patients compared with 4% of placebo-treated patients, with this occurring at two consecutive study visits for 0.9% and 0.3%, respectively.

Label revised Feb 25, 2026. DailyMed

Victoza

  • Mean increases from baseline in heart rate of 2 to 3 beats per minute have been observed in adult patients treated with Victoza compared to placebo.

Label revised Oct 14, 2025. DailyMed

Byetta: no finding on this in the sections read here.

Not from trials

Reports to FDA about a faster heart rate

Counts of voluntary reports from patients and doctors. They cannot show that a medicine caused anything and cannot give a rate, and a brand used by more people draws more reports.

MedicineReports namingAll reports on it
MounjaroPalpitations: 495 · Heart rate increased: 362 · Tachycardia: 26097,440
OzempicPalpitations: 436 · Heart rate increased: 399 · Tachycardia: 15070,863
ByettaHeart rate increased: 383 · Palpitations: 351 · Tachycardia: 7952,087
TrulicityHeart rate increased: 326 · Palpitations: 258 · Tachycardia: 10687,279
ZepboundHeart rate increased: 323 · Palpitations: 305 · Tachycardia: 9780,835
WegovyPalpitations: 277 · Heart rate increased: 169 · Tachycardia: 6925,993
VictozaHeart rate increased: 261 · Palpitations: 245 · Tachycardia: 13441,462
SaxendaPalpitations: 76 · Heart rate increased: 59 · Tachycardia: 327,270
Rybelsus and Ozempic tabletsHeart rate increased: 57 · Palpitations: 49 · Tachycardia: 357,758
FoundayoHeart rate increased: 15 · Palpitations: 9 · Tachycardia: 43,050

Counted through openFDA from FDA's Adverse Event Reporting System, refreshed weekly. One report can name several terms.

Updated automatically

Latest FDA label updates

Written from each source's own record as it changes. Every change on GLPcompare

Questions

Fast heart rate on a GLP-1: common questions

Does Wegovy raise your heart rate?

Its FDA label: Treatment with Wegovy was associated with increases in resting heart rate. Mean increases in resting heart rate of 1 to 4 beats per minute (bpm) were observed in Wegovy injection-treated adult patients compared to placebo in clinical trials for weight reduction.

Does Ozempic raise your heart rate?

Its FDA label: In placebo-controlled trials, Ozempic 0.5 mg and 1 mg resulted in a mean increase in heart rate of 2 to 3 beats per minute. There was a mean decrease in heart rate of 0.3 beats per minute in placebo-treated patients.

Does Rybelsus raise your heart rate?

Its FDA label: Increases in Heart Rate: In placebo-controlled trials, semaglutide tablets 7 mg and 14 mg tablets resulted in a mean increase in heart rate of 1 to 3 beats per minute. There was no change in heart rate in placebo-treated patients.

Does Zepbound raise your heart rate?

Its FDA label: In a pool of Study 1 and 2, treatment with Zepbound resulted in a mean increase in heart rate of 1 to 3 beats per minute compared to no increase in placebo-treated patients.

Does Mounjaro raise your heart rate?

Its FDA label: In the pool of placebo-controlled trials in adults, treatment with Mounjaro resulted in a mean increase in heart rate of 2 to 4 beats per minute compared to a mean increase of 1 beat per minute in placebo-treated patients. Episodes of sinus tachycardia, associated with a concomitant increase from baseline in heart rate of ≥15 beats per minute, also were reported in 4.3%, 4.6%, 5.9% and 10% of subjects treated with placebo, Mounjaro 5 mg, 10 mg, and 15 mg, respectively.

Does Foundayo raise your heart rate?

Its FDA label: In a pool of Trials 1 and 2, tachycardia (tachycardia, heart rate increased, and sinus tachycardia) was reported in 3% of patients treated with Foundayo and 0.9% receiving placebo. Treatment with Foundayo resulted in a mean increase in heart rate of 4 to 5 beats per minute from baseline compared to 0.5 beat per minute with placebo.

Does Trulicity raise your heart rate?

Its FDA label: In adult patients, Trulicity 0.75 mg and 1.5 mg resulted in a mean increase in heart rate (HR) of 2-4 beats per minute (bpm). Sinus tachycardia was reported in 3.0%, 2.8%, and 5.6% of patients treated with placebo, Trulicity 0.75 mg and Trulicity 1.5 mg, respectively.

Does Saxenda raise your heart rate?

Its FDA label: Mean increases in resting heart rate of 2 to 3 beats per minute (bpm) were observed with routine clinical monitoring in Saxenda-treated adult patients compared to placebo in clinical trials. More patients treated with Saxenda, compared with placebo, had changes from baseline at two consecutive visits of more than 10 bpm (34% versus 19%, respectively) and 20 bpm (5% versus 2%, respectively).

Does Victoza raise your heart rate?

Its FDA label: Mean increases from baseline in heart rate of 2 to 3 beats per minute have been observed in adult patients treated with Victoza compared to placebo.

Other side effects

Trial rates describe groups, not what one person will feel. Talk to your clinician before starting, stopping or changing a medicine.

GLPcompare is an informational data platform, not a medical provider or pharmacy. Nothing here is medical advice, a diagnosis, or a recommendation to start, stop, or change any treatment. Data is aggregated from public sources and can be incomplete or out of date. Always confirm with a licensed clinician and the current FDA label.