From each FDA label

Do GLP-1s cause pancreatitis?

10 of the 10 current GLP-1 labels carry a warning on pancreatitis. Wegovy's label says: "Acute pancreatitis, including fatal and non-fatal hemorrhagic or necrotizing pancreatitis, has been observed in patients treated with GLP-1 receptor agonists, including Wegovy."

Read from each manufacturer's FDA label on DailyMed. The newest revision saying anything on this is Aug 28, 2026.

Word for word

What each label says about pancreatitis

Sentences from each label's warnings and side effect sections. Only cross-references are removed.

Wegovy · Warning: Acute Pancreatitis

  • Acute pancreatitis, including fatal and non-fatal hemorrhagic or necrotizing pancreatitis, has been observed in patients treated with GLP-1 receptor agonists, including Wegovy.
  • After initiation of Wegovy, observe patients carefully for signs and symptoms of acute pancreatitis, which may include persistent or severe abdominal pain (sometimes radiating to the back), and which may or may not be accompanied by nausea or vomiting.
  • If pancreatitis is suspected, discontinue Wegovy and initiate appropriate management.
  • The clinical significance of elevations in lipase or amylase with Wegovy is unknown in the absence of other signs and symptoms of pancreatitis.

Label revised Jun 18, 2026. DailyMed

Ozempic · Warning: Acute Pancreatitis

  • Acute pancreatitis, including fatal and non-fatal hemorrhagic or necrotizing pancreatitis, has been observed in patients treated with GLP-1 receptor agonists, including Ozempic.
  • After initiation of Ozempic, observe patients carefully for signs and symptoms of acute pancreatitis, which may include persistent or severe abdominal pain (sometimes radiating to the back), and which may or may not be accompanied by nausea or vomiting.
  • If pancreatitis is suspected, discontinue Ozempic and initiate appropriate management.
  • In glycemic control trials, acute pancreatitis was confirmed by adjudication in 7 Ozempic-treated patients (0.3 cases per 100 patient years) versus 3 in comparator-treated patients (0.2 cases per 100 patient years).

Label revised Jun 1, 2026. DailyMed

Rybelsus and Ozempic tablets · Warning: Acute Pancreatitis

  • Acute pancreatitis, including fatal and non-fatal hemorrhagic or necrotizing pancreatitis, has been observed in patients treated with GLP-1 receptor agonists, including semaglutide tablets.
  • After initiation of Rybelsus or Ozempic tablets, observe patients carefully for signs and symptoms of acute pancreatitis, which may include persistent or severe abdominal pain (sometimes radiating to the back), and which may or may not be accompanied by nausea or vomiting.
  • If pancreatitis is suspected, discontinue Rybelsus or Ozempic tablets and initiate appropriate management.
  • Pancreatitis: In the pool of placebo- and active-controlled trials with semaglutide tablets, pancreatitis was reported as a serious adverse event in 6 semaglutide tablets -treated patients (0.1 events per 100 patient years) versus 1 in comparator-treated patients (<0.1 events per 100 patient years).

Label revised Jan 30, 2026. DailyMed

Zepbound · Warning: Acute Pancreatitis

  • Acute pancreatitis, including fatal and non-fatal hemorrhagic or necrotizing pancreatitis, has been observed in patients treated with GLP-1 receptor agonists, or Zepbound.
  • After initiation of Zepbound, observe patients carefully for signs and symptoms of acute pancreatitis which may include persistent or severe abdominal pain (sometimes radiating to the back) and which may or may not be accompanied by nausea or vomiting.
  • If pancreatitis is suspected, discontinue Zepbound and initiate appropriate management.
  • The clinical significance of elevations in amylase or lipase with Zepbound is unknown in the absence of other signs and symptoms of pancreatitis.

Label revised Aug 28, 2026. DailyMed

Mounjaro · Warning: Acute Pancreatitis

  • Acute pancreatitis, including fatal and non-fatal hemorrhagic or necrotizing pancreatitis, has been observed in patients treated with GLP-1 receptor agonists, or Mounjaro.
  • After initiation of Mounjaro, observe patients carefully for signs and symptoms of acute pancreatitis, which may include persistent or severe abdominal pain (sometimes radiating to the back) and which may or may not be accompanied by nausea or vomiting.
  • If pancreatitis is suspected, discontinue Mounjaro and initiate appropriate management.
  • The clinical significance of elevations in lipase or amylase with Mounjaro is unknown in the absence of other signs and symptoms of pancreatitis.

Label revised Aug 27, 2026. DailyMed

Foundayo · Warning: Acute Pancreatitis

  • Acute pancreatitis has been reported in patients treated with Foundayo.
  • Fatal and non-fatal hemorrhagic or necrotizing pancreatitis have been observed in patients treated with GLP-1 receptor agonists.
  • After initiation of Foundayo, observe patients carefully for signs and symptoms of acute pancreatitis, which may include persistent or severe abdominal pain (sometimes radiating to the back) and which may or may not be accompanied by nausea or vomiting.
  • The clinical significance of elevations in amylase or lipase with Foundayo is unknown in the absence of other signs and symptoms of pancreatitis.

Label revised Jul 29, 2026. DailyMed

Trulicity · Warning: Acute Pancreatitis

  • Acute pancreatitis, including fatal and non-fatal hemorrhagic or necrotizing pancreatitis, has been observed in patients treated with GLP-1 receptor agonists, including Trulicity.
  • After initiation of Trulicity, observe patients carefully for signs and symptoms of acute pancreatitis which may include persistent or severe abdominal pain (sometimes radiating to the back) and which may or may not be accompanied by nausea or vomiting.
  • If pancreatitis is suspected, discontinue Trulicity and initiate appropriate management.
  • Based on an analysis of adjudicated events in a clinical trial evaluating Trulicity 1.5 mg, 3 mg, or 4.5 mg once weekly, pancreatitis occurred in 1 patient exposed to Trulicity 1.5 mg (0.2%), in 2 patients exposed to Trulicity 3 mg (0.3%), and 3 patients exposed to Trulicity 4.5 mg (0.5%).

Label revised Jun 16, 2026. DailyMed

Saxenda · Warning: Acute Pancreatitis

  • Acute pancreatitis, including fatal and non-fatal hemorrhagic or necrotizing pancreatitis, has been observed in patients treated with GLP-1 receptor agonists, including liraglutide.
  • After initiation of Saxenda, observe patients carefully for signs and symptoms of acute pancreatitis which may include persistent or severe abdominal pain (sometimes radiating to the back) and which may or may not be accompanied by nausea or vomiting.
  • If pancreatitis is suspected, discontinue Saxenda and initiate appropriate management.
  • The clinical significance of elevations in lipase or amylase with Saxenda is unknown in the absence of other signs and symptoms of pancreatitis.

Label revised Feb 25, 2026. DailyMed

Victoza · Warning: Acute Pancreatitis

  • Acute pancreatitis, including fatal and non-fatal hemorrhagic or necrotizing pancreatitis, has been observed in patients treated with GLP-1 receptor agonists, including liraglutide.
  • After initiation of Victoza, observe patients carefully for signs and symptoms of acute pancreatitis which may include persistent or severe abdominal pain (sometimes radiating to the back) and which may or may not be accompanied by nausea or vomiting.
  • If pancreatitis is suspected, discontinue Victoza and initiate appropriate management.
  • The clinical significance of elevations in lipase or amylase with Victoza is unknown in the absence of other signs and symptoms of pancreatitis.

Label revised Oct 14, 2025. DailyMed

Byetta · Warning: Acute Pancreatitis

  • Acute pancreatitis, including fatal and non-fatal hemorrhagic or necrotizing pancreatitis, has been observed in patients treated with glucagon-like peptide-1 (GLP-1) receptor agonists, including Byetta.
  • After initiation of Byetta, observe patients carefully for signs and symptoms of pancreatitis (including persistent severe abdominal pain, sometimes radiating to the back and which may or may not be accompanied by vomiting).
  • If pancreatitis is suspected, discontinue Byetta and initiate appropriate management.

Label revised Sep 2, 2025. DailyMed

Not from trials

Reports to FDA about pancreatitis

Counts of voluntary reports from patients and doctors. They cannot show that a medicine caused anything and cannot give a rate, and a brand used by more people draws more reports.

MedicineReports namingAll reports on it
VictozaPancreatitis: 2,184 · Pancreatitis acute: 67141,462
ByettaPancreatitis: 2,004 · Pancreatitis acute: 74252,087
TrulicityPancreatitis: 1,491 · Pancreatitis acute: 30487,279
OzempicPancreatitis: 1,169 · Pancreatitis acute: 26970,863
MounjaroPancreatitis: 1,086 · Pancreatitis acute: 28497,440
ZepboundPancreatitis: 314 · Pancreatitis acute: 5980,835
WegovyPancreatitis: 240 · Pancreatitis acute: 8725,993
SaxendaPancreatitis: 228 · Pancreatitis acute: 567,270
Rybelsus and Ozempic tabletsPancreatitis: 173 · Pancreatitis acute: 327,758
FoundayoPancreatitis: 7 · Pancreatitis acute: 43,050

Counted through openFDA from FDA's Adverse Event Reporting System, refreshed weekly. One report can name several terms.

Updated automatically

Latest FDA label updates

Written from each source's own record as it changes. Every change on GLPcompare

Questions

Pancreatitis on a GLP-1: common questions

Does Wegovy cause pancreatitis?

Its FDA label: Acute pancreatitis, including fatal and non-fatal hemorrhagic or necrotizing pancreatitis, has been observed in patients treated with GLP-1 receptor agonists, including Wegovy. After initiation of Wegovy, observe patients carefully for signs and symptoms of acute pancreatitis, which may include persistent or severe abdominal pain (sometimes radiating to the back), and which may or may not be accompanied by nausea or vomiting.

Does Ozempic cause pancreatitis?

Its FDA label: Acute pancreatitis, including fatal and non-fatal hemorrhagic or necrotizing pancreatitis, has been observed in patients treated with GLP-1 receptor agonists, including Ozempic. After initiation of Ozempic, observe patients carefully for signs and symptoms of acute pancreatitis, which may include persistent or severe abdominal pain (sometimes radiating to the back), and which may or may not be accompanied by nausea or vomiting.

Does Rybelsus cause pancreatitis?

Its FDA label: Acute pancreatitis, including fatal and non-fatal hemorrhagic or necrotizing pancreatitis, has been observed in patients treated with GLP-1 receptor agonists, including semaglutide tablets. After initiation of Rybelsus or Ozempic tablets, observe patients carefully for signs and symptoms of acute pancreatitis, which may include persistent or severe abdominal pain (sometimes radiating to the back), and which may or may not be accompanied by nausea or vomiting.

Does Zepbound cause pancreatitis?

Its FDA label: Acute pancreatitis, including fatal and non-fatal hemorrhagic or necrotizing pancreatitis, has been observed in patients treated with GLP-1 receptor agonists, or Zepbound. After initiation of Zepbound, observe patients carefully for signs and symptoms of acute pancreatitis which may include persistent or severe abdominal pain (sometimes radiating to the back) and which may or may not be accompanied by nausea or vomiting.

Does Mounjaro cause pancreatitis?

Its FDA label: Acute pancreatitis, including fatal and non-fatal hemorrhagic or necrotizing pancreatitis, has been observed in patients treated with GLP-1 receptor agonists, or Mounjaro. After initiation of Mounjaro, observe patients carefully for signs and symptoms of acute pancreatitis, which may include persistent or severe abdominal pain (sometimes radiating to the back) and which may or may not be accompanied by nausea or vomiting.

Does Foundayo cause pancreatitis?

Its FDA label: Acute pancreatitis has been reported in patients treated with Foundayo. Fatal and non-fatal hemorrhagic or necrotizing pancreatitis have been observed in patients treated with GLP-1 receptor agonists.

Does Trulicity cause pancreatitis?

Its FDA label: Acute pancreatitis, including fatal and non-fatal hemorrhagic or necrotizing pancreatitis, has been observed in patients treated with GLP-1 receptor agonists, including Trulicity. After initiation of Trulicity, observe patients carefully for signs and symptoms of acute pancreatitis which may include persistent or severe abdominal pain (sometimes radiating to the back) and which may or may not be accompanied by nausea or vomiting.

Does Saxenda cause pancreatitis?

Its FDA label: Acute pancreatitis, including fatal and non-fatal hemorrhagic or necrotizing pancreatitis, has been observed in patients treated with GLP-1 receptor agonists, including liraglutide. After initiation of Saxenda, observe patients carefully for signs and symptoms of acute pancreatitis which may include persistent or severe abdominal pain (sometimes radiating to the back) and which may or may not be accompanied by nausea or vomiting.

Does Victoza cause pancreatitis?

Its FDA label: Acute pancreatitis, including fatal and non-fatal hemorrhagic or necrotizing pancreatitis, has been observed in patients treated with GLP-1 receptor agonists, including liraglutide. After initiation of Victoza, observe patients carefully for signs and symptoms of acute pancreatitis which may include persistent or severe abdominal pain (sometimes radiating to the back) and which may or may not be accompanied by nausea or vomiting.

Other side effects

Trial rates describe groups, not what one person will feel. Talk to your clinician before starting, stopping or changing a medicine.

GLPcompare is an informational data platform, not a medical provider or pharmacy. Nothing here is medical advice, a diagnosis, or a recommendation to start, stop, or change any treatment. Data is aggregated from public sources and can be incomplete or out of date. Always confirm with a licensed clinician and the current FDA label.