US self-pay prices · not FDA-approved

Compounded tirzepatide vs compounded semaglutide

Prices checked through Nov 6, 2026

Compounded tirzepatide usually costs more: at the 61 US sellers that price both month to month, it runs a typical $70 a month above compounded semaglutide. The only large head-to-head trial, SURMOUNT-5, tested the FDA-approved brands: Zepbound lost a mean 20.2% of body weight and Wegovy 13.7% over 72 weeks. No such trial has tested the compounded versions, which are not FDA-approved. SURMOUNT-5 (SURMOUNT-5 in the New England Journal of Medicine)

Lowest prices now

  • Lowest compounded tirzepatide, not FDA-approved

    Affinity Direct

    $147.90/28 days · about $158 per 30 days

    View

  • Lowest compounded semaglutide, not FDA-approved

    Strut Health

    $99/30 days · about $99 per 30 days

    View
Side by side

Price and evidence

Compounded tirzepatideCompounded semaglutide
Typical price, starting dose$235/mo$169/mo
Lowest per 30 days, supply stated≈ $158 per 30 days, Affinity Direct$99 per 30 days, Strut Health
Lowest month to month$129/mo, Eden$89/mo, yourEra
Lowest at the full dose≈ $213 per 30 days at 15 mg, Gimme Care≈ $160 per 30 days at 2.5 mg, NiceRx
US sellers with a current price8987
Mean weight change, SURMOUNT-5 (FDA-approved brand, 72 weeks)-20.2% (Zepbound)-13.7% (Wegovy)

Adults with obesity, or overweight with a weight-related condition, without diabetes. Randomized, open-label, 751 people. This trial did not test Wegovy tablets or Wegovy HD. It was not powered to establish a safety or tolerability advantage. The trial did not test compounded products.

Same seller, same plan

What the same seller charges for each

Month-to-month injections at sellers that price both on the same billing cycle, lowest tirzepatide first. A price may rise with the dose: each seller's page says.

Compounded drugs are not FDA-approved: the FDA does not review them for safety, effectiveness or quality before they are marketed. FDA (FDA: concerns with unapproved GLP-1 drugs used for weight loss)

GLPcompare links out only to sellers with a referral program: if you sign up or buy through one of those links, we may earn a commission at no extra cost to you. For other sellers we show the price and the seller's address, and suggest sellers we can link to. It never changes the price you pay or the underlying data. Partner status and commission rates contribute to offer and provider value scores and can change their order. Every partner is labeled. Value scores are not medical recommendations; a higher-ranked offer is not necessarily the lowest price or the right product for you.

Questions

Common questions

Is compounded tirzepatide better than compounded semaglutide?

No trial has compared the compounded products. In SURMOUNT-5, the FDA-approved Zepbound produced a mean weight change of -20.2% against -13.7% for Wegovy over 72 weeks, and both groups used their maximum tolerated dose. Those results belong to the approved products. Compounded drugs are not FDA-approved: the FDA does not review them for safety, effectiveness or quality before they are marketed. A clinician can say which is right for you.

How much more does compounded tirzepatide cost than compounded semaglutide?

Typically $235 against $169 a month at the starting dose across all sellers. At the 61 sellers that price both month to month, the typical gap is $70 a month.

What is cheaper, compounded semaglutide or tirzepatide?

Semaglutide, from $99 per 30 days at Strut Health, against tirzepatide from ≈ $158 per 30 days at Affinity Direct, where the seller states the supply.

Can I switch from compounded semaglutide to tirzepatide?

That is a prescriber's decision, including the dose you start on. Some sellers sell both at set prices: the table on this page shows them.

GLPcompare is an informational data platform, not a medical provider or pharmacy. Nothing here is medical advice, a diagnosis, or a recommendation to start, stop, or change any treatment. Data is aggregated from public sources and can be incomplete or out of date. Always confirm with a licensed clinician and the current FDA label.