Foundayo vs Zepbound
Foundayo contains orforglipron. Zepbound contains tirzepatide. Compare approved uses, formulations, and self-pay prices.
| Compare | Foundayo | Zepbound |
|---|---|---|
| Active ingredient | OrforglipronSmall-molecule GLP-1 | TirzepatideGIP/GLP-1 |
| How it is taken | Tablet Once daily, with or without food | Injection Once weekly |
| Manufacturer | Eli Lilly | Eli Lilly |
What was actually compared
No direct trial comparing these exact brands is included in our reviewed catalog. Results from separate trials are not a direct comparison of these products.
Weight-loss results by formulation
Each result belongs to its named trial and dose. Separate trials have different participants and methods; these figures are not a direct comparison.
| Compare | Foundayo | Zepbound |
|---|---|---|
| Injection evidence | No reviewed weight-loss result for this brand and formulation. | −20.9% (-20.9% at 72 wks · SURMOUNT-1 · 15 mg weekly (Zepbound)) SURMOUNT-1 · -20.9% at 72 wks 15 mg weekly (Zepbound) Accounts for treatment discontinuation |
| Tablet evidence | −11.2% (-11.2% at 72 wks · ATTAIN-1 · 17.2 mg daily (Foundayo; 36 mg capsule-equivalent in ATTAIN-1)) ATTAIN-1 · -11.2% at 72 wks 17.2 mg daily (Foundayo; 36 mg capsule-equivalent in ATTAIN-1) Accounts for treatment discontinuation | No reviewed weight-loss result for this brand and formulation. |
Entry price and maintenance price
Self-pay quotes, not insurance estimates. Each figure identifies the product, provider, and dose where published.
| Compare | Foundayo | Zepbound |
|---|---|---|
| Injection prices | No reviewed injection formulation in this brand record. | Advertised entry price $299-$449/28 days28-day supply (zepbound.lilly.com) ≈ $320.36 per 30 days at this quoted rate Checked Zepbound KwikPen (multi-dose pen)
self-pay cash, by dose ($299 / $399 / $449) Price conditionsself-pay cash, by dose ($299 / $399 / $449) Each pen holds four doses, one month's (28-day) supply. $299 at 2.5 mg and $399 at 5 mg; $449 at 7.5 to 15 mg under the Self Pay Journey offer, which holds only with a refill within 45 days. 28-day supply Published maintenance dose $449/28 days28-day supply (zepbound.lilly.com) ≈ $481.07 per 30 days at this quoted rate Checked At 15 mg Zepbound KwikPen (multi-dose pen)
Published price at 15 mg Price conditionsPublished price at 15 mg Each pen holds four doses, one month's (28-day) supply. $299 at 2.5 mg and $399 at 5 mg; $449 at 7.5 to 15 mg under the Self Pay Journey offer, which holds only with a refill within 45 days. Self Pay Journey price for 7.5-15 mg with a refill within 45 days; otherwise $499 (7.5 mg) or $699 (10-15 mg). 28-day supply |
| Tablet prices | Advertised entry price from $149/mo30-day supply (lilly.com) $149 per 30 days at this quoted rate Checked Foundayo (LillyDirect self-pay)
self-pay cash, lowest dose; ~$25/mo with commercial coverage through the savings card, which ends Dec 31, 2026 Price conditionsself-pay cash, lowest dose; ~$25/mo with commercial coverage through the savings card, which ends Dec 31, 2026 LillyDirect self-pay ladder, each a 30-day supply: $149 (0.8 mg), $199 (2.5 mg), $299 (5.5 and 9 mg), $299 (14.5 and 17.2 mg with a 45-day refill, else $349); the 2.5 mg and 5.5 mg doses are temporarily $149 and $199 through Dec 31, 2026. 30-day supply Published maintenance dose $299/mo30-day supply (lilly.com) $299 per 30 days at this quoted rate Checked At 17.2 mg Foundayo (LillyDirect self-pay)
Published price at 17.2 mg Price conditionsPublished price at 17.2 mg LillyDirect self-pay ladder, each a 30-day supply: $149 (0.8 mg), $199 (2.5 mg), $299 (5.5 and 9 mg), $299 (14.5 and 17.2 mg with a 45-day refill, else $349); the 2.5 mg and 5.5 mg doses are temporarily $149 and $199 through Dec 31, 2026. Self-Pay Journey price for 14.5 mg and 17.2 mg with a refill within 45 days; regular price $349. Eligibility, additional taxes and fees may apply. 30-day supply | No reviewed tablet formulation in this brand record. |
How these quotes are selected
For each price basis, we prefer a recently checked manufacturer-direct quote, then a recently checked provider quote for that brand and formulation. Within each group, documented 30-day costs come first, lowest to highest. Quotes without a documented supply period have no cost rank. Older quotes appear as dated references only when no current quote is tracked. Providers may differ between entry and maintenance prices. Missing maintenance prices are never replaced with entry prices. Compounded products, combined brand quotes, and membership-only fees are excluded. Prices at different doses are not equivalent treatment costs; confirm supply length, eligibility, and added fees.
Every cash quote was checked on or after . Each quote shows its own check date. A quoted maintenance dose is not a dosing recommendation. Our methodology
Foundayo vs Zepbound side effects
Rate on the medicine, with the placebo rate in brackets, at the highest dose in each label's table. These come from separate trials, so they are not a head-to-head comparison.
| Side effect | Foundayo 17.2 mg | Zepbound 15 mg |
|---|---|---|
| Nausea | 35% (10%) | 28% (8%) |
| Diarrhea | 25% (11%) | 23% (8%) |
| Vomiting | 24% (4%) | 13% (2%) |
| Constipation | 24% (9%) | 11% (5%) |
| Abdominal pain | 14% (7%) | 10% (5%) |
| Indigestion | 13% (4%) | 10% (4%) |
| Fatigue | 9% (4%) | 7% (3%) |
| Headache | 9% (7%) | not in table |
| Dizziness | not in table | 4% (2%) |
| Injection site reactions | not in table | 8% (2%) |
| Burping | 8% (1%) | 5% (1%) |
| Reflux | 7% (2%) | 5% (2%) |
| Gas | 6% (2%) | 4% (2%) |
| Bloating | 8% (3%) | 4% (2%) |
| Hair loss | 5% (2%) | 5% (1%) |
Foundayo vs Zepbound: timing, generics and coverage
Read from each FDA label, FDA's Orange Book and CMS's Part D files, and updated when they change.
| Brand | Soonest top dose | Half-life | Generic approved? | Patent on the medicine to | On Medicare Part D, 2025 |
|---|---|---|---|---|---|
| Zepbound | 15 mg from week 21 | about 5-6 days | No | May 13, 2036 | 160,298 |
| Foundayo | 17.2 mg from day 151 | about 29 to 49 hours | No | Sep 26, 2037 | None listed |
How long each takes · Generics and patents · Who covers what
Approved uses by formulation
Eligibility, contraindications, and warnings are in each product's full prescribing information.
| Compare | Foundayo | Zepbound |
|---|---|---|
| Injection | No reviewed injection label in this brand record. Ingredient record | Weight management in adults with obesity, or overweight with a weight-related condition; moderate to severe obstructive sleep apnea in adults with obesity. US prescribing information (Zepbound Injection prescribing information)Reviewed Nov 4, 2026 |
| Tablet | Weight management in adults with obesity, or overweight with a weight-related condition. US prescribing information (Foundayo Tablet prescribing information)Reviewed Nov 4, 2026 | No reviewed tablet label in this brand record. Ingredient record |
Full evidence and safety information
What changed for Foundayo and Zepbound
- PricebmiMD: Compounded tirzepatide via bmiMD now $179/mo (was $249/mo) (read on bmimd.com)
- PriceWellorithm: Compounded tirzepatide via Wellorithm now $399/mo (was $349/mo) (read on wellorithm.com)
- PriceStrut Health: Compounded tirzepatide via Strut Health now from $149/mo (was $219/mo) (read on struthealth.com)
- PriceEnhance.MD: Microdose tirzepatide via Enhance.MD now $189/mo (was $169/mo) (read on enhance.md)
- PriceFifty 410: Compounded tirzepatide via Fifty 410 now $199/4 weeks (was $133/mo) (read on fifty410.com)
- PriceStrut Health: Compounded tirzepatide via Strut Health now $219/mo (was $149/30 days) (read on struthealth.com)
Written from each source's own record as it changes. Every change on GLPcompare
Foundayo vs Zepbound: common questions
Is Foundayo the same as Zepbound?
No. Foundayo contains orforglipron and Zepbound contains tirzepatide, which are different medicines.
Is Foundayo or Zepbound better for weight loss?
No trial on our list compared them directly. In separate trials: Foundayo -11.2% at 72 wks in ATTAIN-1 (17.2 mg daily (Foundayo; 36 mg capsule-equivalent in ATTAIN-1)); Zepbound -20.9% at 72 wks in SURMOUNT-1 (15 mg weekly (Zepbound)). Separate trials enrolled different people for different lengths of time, so these figures cannot rank them.
Is Foundayo or Zepbound safer?
We know of no trial set up to answer that. Stopping because of side effects, each in its own trial and not a head-to-head figure: Foundayo 10.3% vs 2.7% placebo (36 mg) (ATTAIN-1 (36 mg, 72 wks, obesity)); Zepbound 6.2% vs 2.6% placebo (15 mg) (SURMOUNT-1 (15 mg, 72 wks, obesity)). Each FDA label lists its own warnings, and which ones matter depends on your health. Side effects compared, from each FDA label
What Zepbound dose is equivalent to Foundayo?
No FDA label sets a dose of Foundayo that equals a dose of Zepbound, and we know of no trial that defines one. Switching is a prescriber's decision, and each label sets its own starting dose and steps. Each label's doses and steps