From the FDA label

How to use Zepbound

Zepbound's FDA-approved Instructions for Use cover 4 products: single-dose pen; single-dose vial; multiple-dose vial; multi-dose kwikpen. Each is below in the label's own words. Talk to your healthcare provider about how to inject it the right way.

The label's pictures are in the original: FDA label on DailyMed (Eli Lilly and Company), revised , version 40. Read every day: a new FDA version updates this page by itself.

Instructions for Use

Zepbound: single-dose pen

Every step, in the label's own words
  • Important information you need to know before injecting Zepbound
  • Read this Instructions for Use and the Medication Guide before using your Zepbound pen and each time you get a refill. There may be new information. This information does not take the place of talking to your healthcare provider about your medical condition or treatment.
  • Talk to your healthcare provider about how to inject Zepbound the right way.
  • Zepbound is a single-dose prefilled pen.
  • Zepbound is used 1 time each week.
  • Inject under the skin (subcutaneously) only.
  • You or another person can inject into your stomach (abdomen) or thigh.
  • Another person can inject into the back of your upper arm.
  • Guide to parts
  • Preparing to inject Zepbound
  • Remove the pen from the refrigerator. Leave the gray base cap on until you are ready to inject.
  • Check the pen label to make sure you have the right medicine and dose, and that it has not expired. Inspect the pen to make sure that it is not damaged.
  • Make sure the medicine:
  • is not frozen is not cloudy is colorless to slightly yellow does not have particles
  • Wash your hands.
  • Step 1 Choose your injection site
  • Your healthcare provider can help you choose the injection site that is best for you. You or another person can inject the medicine in your stomach (abdomen) or thigh.
  • Another person should give you the injection in the back of your upper arm. Change (rotate) your injection site each week. You may use the same area of your body but be sure to choose a different injection site in that area.
  • Step 2 Pull off the gray base cap
  • Make sure the pen is locked. Do not unlock the pen until you place the clear base on your skin and are ready to inject.
  • Pull the gray base cap straight off and throw it away in your household trash. Do not put the gray base cap back on – this could damage the needle. Do not touch the needle.
  • Step 3 Place clear base on skin, then unlock
  • Place the clear base flat against your skin at the injection site.
  • Unlock by turning the lock ring.
  • Step 4 Press and hold up to 10 seconds
  • Press and hold the purple injection button for up to 10 seconds. Listen for: First click = injection started Second click = injection completed
  • You will know your injection is complete when the gray plunger is visible.
  • After your injection, place the used pen in a sharps container.
  • See Disposing of your used pen.
  • Disposing of your used pen
  • Put your used pen in an FDA-cleared sharps disposal container right away after use. Do not throw away (dispose of) pens in your household trash.
  • If you do not have an FDA-cleared sharps disposal container, you may use a household container that is: - made of a heavy-duty plastic, - can be closed with a tight-fitting, puncture-resistant lid, without sharps being able to come out, - upright and stable during use, - leak-resistant, and - properly labeled to warn of hazardous waste inside the container.
  • When your sharps disposal container is almost full, you will need to follow your community guidelines for the right way to dispose of your sharps disposal container. There may be state or local laws about how you should throw away used needles and syringes. For more information about safe sharps disposal, and for specific information about sharps disposal in the state that you live in, go to the FDA's website at: http://www.fda.gov/safesharpsdisposal.
  • Do not recycle your used sharps disposal container.
  • Storage and handling
  • Store your pen in the refrigerator between 36°F to 46°F (2°C to 8°C).
  • You may store your pen at room temperature up to 86°F (30°C) for up to a total of 21 days.
  • Discard the pen after a total of 21 days at room temperature.
  • Do not freeze your pen. If the pen has been frozen, throw the pen away and use a new pen.
  • Store your pen in the original carton to protect your pen from light.
  • The pen has glass parts. Handle it carefully. If you drop the pen on a hard surface, do not use it. Use a new pen for your injection.
  • Keep your Zepbound pen and all medicines out of the reach of children.
  • Commonly asked questions
  • What if I see air bubbles in my pen?
  • Air bubbles are normal.
  • What if my pen is not at room temperature?
  • It is not necessary to warm the pen to room temperature.
  • What if I unlock the pen and press the purple injection button before pulling off the gray base cap?
  • Do not remove the gray base cap. Throw away the pen and get a new pen.
  • What if there is a drop of liquid on the tip of the needle when I remove the gray base cap?
  • A drop of liquid on the tip of the needle is normal. Do not touch the needle.
  • Do I need to hold the injection button down until the injection is complete?
  • This is not necessary, but it may help you keep the pen steady against your skin.
  • I heard more than 2 clicks during my injection—2 loud clicks and 1 soft one. Did I get my complete injection?
  • Some people may hear a soft click right before the second loud click. That is the normal operation of the pen. Do not remove the pen from your skin until you hear the second loud click.
  • I am not sure if my pen worked the right way.
  • Check to see if you have received your dose. Your dose was delivered the right way if the gray plunger is visible. Also, see Step 4 of the instructions. If you do not see the gray plunger, contact Lilly at 1-800-Lilly-Rx (1-800-545-5979) for further instructions. Until then, store your pen safely to avoid an accidental needle stick.
  • What if there is a drop of liquid or blood on my skin after my injection?
  • This is normal. Press a cotton ball or gauze over the injection site. Do not rub the injection site.
  • Other information
  • If you have vision problems, do not use your pen without help from a person trained to use the Zepbound pen.
  • Where to learn more
  • If you have questions or problems with your Zepbound pen, contact Lilly at 1-800-Lilly-Rx (1-800-545-5979) or call your healthcare provider.
  • Scan this code to launch www.zepbound.com
  • ZEP-0003-PEN-IFU-20260422
Instructions for Use

Zepbound: single-dose vial

Every step, in the label's own words
  • Important information you need to know before injecting Zepbound
  • Read this Instructions for Use before you start taking Zepbound and each time you get a new vial. There may be new information. This information does not take the place of talking to your healthcare provider about your medical condition or your treatment.
  • Do not share your needles or syringes with other people. You may give other people a serious infection or get a serious infection from them.
  • Talk to your healthcare provider about how to inject Zepbound the right way.
  • Zepbound is a single-dose vial.
  • Zepbound is used 1 time each week.
  • Inject under the skin (subcutaneously) only.
  • You or another person may inject into your stomach (abdomen) or thigh.
  • Another person can inject into the back of your upper arm.
  • Gather supplies needed to give your injection
  • 1 single-dose Zepbound vial
  • 1 syringe and 1 needle, supplied separately (for example, use a 1 mL syringe and needle as recommended by your healthcare provider)
  • 1 alcohol swab
  • gauze
  • 1 sharps container for throwing away used needles and syringes. See “Disposing of used needles and syringes” at the end of these instructions.
  • Guide to parts Vial Needle and Syringe (not included)
  • Note: The needle and syringe are not included. The needle and syringe recommended by your healthcare provider may look different than the needle and syringe in this Instructions for Use.
  • Preparing to inject Zepbound
  • Remove the vial from the refrigerator.
  • Check the vial label to make sure you have the right medicine and dose, and that it has not expired.
  • Make sure the medicine:
  • is not frozen is not cloudy is colorless to slightly yellow does not have particles
  • Always use a new syringe and needle for each injection to prevent infections and blocked needles. Do not reuse or share your syringes or needles with other people. You may give other people a serious infection or get a serious infection from them.
  • Wash your hands with soap and water.
  • Step 1: Pull off the plastic protective cap. Do not remove the rubber stopper.
  • Step 2: Wipe the rubber stopper with an alcohol swab.
  • Step 3: Remove the outer wrapping from the syringe.
  • Step 4: Remove the outer wrapping from the needle. The syringe that your healthcare provider recommended may have a pre-attached needle. If the needle is attached, skip to step 6.
  • Step 5: Place the needle on top of the syringe and turn until it is tight and firmly attached.
  • Step 6: Remove the needle shield by pulling straight off.
  • Step 7: Hold the syringe in one hand with the needle pointing up. With the other hand pull down on the plunger until the plunger tip reaches the line on the syringe indicating that 0.5 mL of air has been drawn into the syringe.
  • Step 8: Push the needle through the rubber stopper of the vial.
  • Step 9: Push the plunger all the way in. This puts air into the vial and makes it easier to pull the solution from the vial.
  • Step 10: Turn the vial and syringe upside down. Make sure that the tip of the needle is in the liquid and slowly pull the plunger down until the plunger tip is past the 0.5 mL line. If there are air bubbles, tap the syringe gently a few times to let any air bubbles rise to the top.
  • Step 11: Slowly push the plunger up until the plunger tip reaches the 0.5 mL line.
  • Step 12: Pull the syringe out of the rubber stopper of the vial.
  • Injecting Zepbound
  • Inject exactly as your healthcare provider has shown you. Your healthcare provider should tell you if you should pinch the skin before injecting.
  • Change (rotate) your injection site within the area you choose for each dose to reduce your risk of getting lipodystrophy (pits in skin or thickened skin) and localized cutaneous amyloidosis (skin with lumps) at the injection sites.
  • Do not inject where the skin has pits, is thickened, or has lumps.
  • Do not inject where the skin is tender, bruised, scaly or hard, or into scars or damaged skin.
  • Do not mix Zepbound with any other medicine.
  • Do not inject Zepbound in the same injection site used for other medicines.
  • Step 13: Choose your injection site. You can inject Zepbound under the skin (subcutaneously) of your stomach area (abdomen) or thighs. Someone else can inject in your stomach area, thighs, or the back of the upper arms.
  • Step 14: Insert the needle into your skin.
  • Step 15: Push down on the plunger to inject your dose. The needle should stay in your skin for at least 5 seconds to make sure you have injected all of your dose.
  • Step 16: Pull the needle out of your skin. If you see blood after you take the needle out of your skin, press the injection site with a piece of gauze. Do not rub the area. Do not recap the needle. Recapping the needle can lead to a needle stick injury.
  • Disposing of used needles and syringes
  • Put your used needle and syringe in an FDA-cleared sharps disposal container right away after use. Do not throw away (dispose of) loose needles and syringes in your household trash.
  • If you do not have an FDA-cleared sharps disposal container, you may use a household container that is: - made of a heavy-duty plastic, - can be closed with a tight-fitting, puncture-resistant lid, without sharps being able to come out, - upright and stable during use, - leak-resistant, and - properly labeled to warn of hazardous waste inside the container.
  • When your sharps disposal container is almost full, you will need to follow your community guidelines for the right way to dispose of your sharps disposal container. There may be state or local laws about how you should throw away used needles and syringes. For more information about safe sharps disposal, and for specific information about sharps disposal in the state that you live in, go to the FDA’s website at: http://www.fda.gov/safesharpsdisposal.
  • Do not dispose of your used sharps disposal container in your household trash unless your community guidelines permit this. Do not recycle your used sharps disposal container.
  • Storing Zepbound
  • Store all unopened vials in the refrigerator at 36°F to 46°F (2°C to 8°C).
  • You may store the unopened vial at room temperature up to 86°F (30°C) for up to a total of 21 days.
  • Discard the vial after a total of 21 days at room temperature.
  • Do not freeze. Do not use if Zepbound has been frozen.
  • Store the vial in the original carton to protect from light.
  • Throw away all opened vials after use, even if there is medicine left in the vial.
  • Keep Zepbound vials, syringes, needles, and all medicines out of the reach of children.
  • If you have any questions or problems with your Zepbound, contact Lilly at 1-800-Lilly-Rx (1-800-545-5979) or call your healthcare provider for help.
  • ZEP-0002-VL-IFU-20260422
Instructions for Use

Zepbound: multiple-dose vial

Every step, in the label's own words
  • INSTRUCTIONS FOR USE
  • Zepbound® [ZEHP-bownd]
  • (tirzepatide)
  • injection, for subcutaneous use
  • Multi-dose vial
  • Each vial contains 4 doses, one dose taken weekly.
  • Important information you need to know before injecting Zepbound
  • Read this Instructions for Use before you start taking Zepbound and each time you get a new vial. There may be new information. This information does not take the place of talking to your healthcare provider about your medical condition or your treatment.
  • Do not share your needles or syringes with other people.
  • Talk to your healthcare provider about how to inject Zepbound the right way.
  • Zepbound is a multi-dose vial. The vial contains 4 doses, one dose taken weekly.
  • Inject 0.6 mL in a single weekly injection, under the skin (subcutaneously).
  • You or another person may inject into your stomach (abdomen) or thigh.
  • Another person can inject into the back of your upper arm.
  • Gather supplies needed to give your injection
  • 1 multi-dose Zepbound vial
  • 1 syringe and 1 needle, supplied separately (for example, use a 1 mL syringe and needle as recommended by your healthcare provider)
  • 1 alcohol swab
  • gauze
  • 1 sharps container for throwing away used needles and syringes. See “Disposing of used needles and syringes” at the end of these instructions.
  • Guide to parts
  • Vial Needle and Syringe (not included)
  • Note: The needle and syringe are not included. The needle and syringe recommended by your healthcare provider may look different than the needle and syringe in this Instructions for Use.
  • Preparing to inject Zepbound
  • Check the vial label to make sure you have the right medicine and dose, and that it has not expired.
  • Make sure the medicine:
  • is not frozen is not cloudy is colorless to slightly yellow does not have particles
  • Always use a new syringe and needle for each injection to prevent infections and blocked needles. Do not reuse or share your syringes or needles with other people. You may give other people a serious infection or get a serious infection from them.
  • Wash your hands with soap and water.
  • Step 1: If you are using a new vial, pull off the plastic protective cap. Do not remove the rubber stopper.
  • Step 2: Wipe the rubber stopper with an alcohol swab.
  • Step 3: Remove the outer wrapping from the syringe.
  • Step 4: Remove the outer wrapping from the needle. The syringe that your healthcare provider recommended may have a pre-attached needle. If the needle is attached, skip to step 6.
  • Step 5: Place the needle on top of the syringe and turn until it is tight and firmly attached.
  • Step 6: Remove the needle shield by pulling straight off.
  • Step 7: Hold the syringe in one hand with the needle pointing up. With the other hand pull down on the plunger until the plunger tip reaches the line on the syringe indicating that 0.6 mL of air has been drawn into the syringe.
  • Step 8: Push the needle through the rubber stopper of the vial.
  • Step 9: Push the plunger all the way in. This puts air into the vial and makes it easier to pull the solution from the vial.
  • Step 10: Turn the vial and syringe upside down. Make sure that the tip of the needle is in the liquid and slowly pull the plunger down until the plunger tip is past the 0.6 mL line. If there are air bubbles, tap the syringe gently a few times to let any air bubbles rise to the top.
  • Step 11: Slowly push the plunger up until the plunger tip reaches the 0.6 mL line.
  • Step 12: Pull the syringe out of the rubber stopper of the vial.
  • Injecting Zepbound
  • Inject exactly as your healthcare provider has shown you. Your healthcare provider should tell you if you should pinch the skin before injecting.
  • Change (rotate) your injection site within the area you choose for each dose to reduce your risk of getting lipodystrophy (pits in skin or thickened skin) and localized cutaneous amyloidosis (skin with lumps) at the injection sites.
  • Do not inject where the skin has pits, is thickened, or has lumps.
  • Do not inject where the skin is tender, bruised, scaly or hard, or into scars or damaged skin.
  • Do not mix Zepbound with any other medicine.
  • Do not inject Zepbound in the same injection site used for other medicines.
  • Step 13: Choose your injection site. You can inject Zepbound under the skin (subcutaneously) of your stomach area (abdomen) or thighs. Someone else can inject in your stomach area, thighs, or the back of the upper arms.
  • Step 14: Insert the needle into your skin.
  • Step 15: Push down on the plunger to inject your dose. The needle should stay in your skin for at least 5 seconds to make sure you have injected all of your dose.
  • Step 16: Pull the needle out of your skin. If you see blood after you take the needle out of your skin, press the injection site with a piece of gauze. Do not rub the area. Do not recap the needle. Recapping the needle can lead to a needle stick injury.
  • Disposing of used needles and syringes
  • Put your used needle and syringe in an FDA-cleared sharps disposal container right away after use. Do not throw away (dispose of) loose needles and syringes in your household trash.
  • If you do not have an FDA-cleared sharps disposal container, you may use a household container that is: - made of a heavy-duty plastic, - can be closed with a tight-fitting, puncture-resistant lid, without sharps being able to come out, - upright and stable during use, - leak-resistant, and - properly labeled to warn of hazardous waste inside the container.
  • When your sharps disposal container is almost full, you will need to follow your community guidelines for the right way to dispose of your sharps disposal container. There may be state or local laws about how you should throw away used needles and syringes. For more information about safe sharps disposal, and for specific information about sharps disposal in the state that you live in, go to the FDA's website at: http://www.fda.gov/safesharpsdisposal.
  • Do not dispose of your used sharps disposal container in your household trash unless your community guidelines permit this. Do not recycle your used sharps disposal container.
  • Storing Zepbound
  • Do not freeze. Do not use if Zepbound has been frozen.
  • Store Zepbound in original carton. Keep away from light.
  • Unopened vial:
  • Store unopened vial in the refrigerator at 36°F to 46°F (2°C to 8°C). It can be used until the expiration date on the label if kept in the refrigerator.
  • If stored at room temperature [up to 86°F (30°C)], throw away unopened vial after 30 days.
  • After vial has been opened:
  • Store opened (in-use) vial in the original carton in the refrigerator at 36°F to 46°F (2°C to 8°C) or at room temperature [up to 86°F (30°C)]. Throw away opened vial after a total of 30 days at room temperature, 30 days after first use, or after taking 4 weekly doses, even if there is medicine left in it.
  • Keep Zepbound vials, syringes, needles, and all medicines out of the reach of children.
  • If you have any questions or problems with your Zepbound, contact Lilly at 1-800-Lilly-Rx (1-800-545-5979) or call your healthcare provider for help.
  • ZEP-0001-MDV-IFU-20260107
Instructions for Use

Zepbound: multi-dose kwikpen

Every step, in the label's own words
  • INSTRUCTIONS FOR USE
  • Zepbound ® [ZEHP-bownd] KwikPen ® [KWIHK pehn]
  • (tirzepatide)
  • injection, for subcutaneous use
  • multi-dose single-patient-use prefilled pen
  • Each pen contains 4 fixed doses, one dose taken weekly.
  • This Instructions for Use contains information on how to inject Zepbound.
  • Important information you need to know before injecting Zepbound
  • Read this INSTRUCTIONS FOR USE before you start injecting Zepbound KwikPen (Pen) and each time you get another new Pen. There may be new information. This information does not take the place of talking to your healthcare provider about your medical condition or your treatment.
  • Zepbound KwikPen is a disposable multi-dose single-patient-use prefilled pen. The Pen contains 4 fixed doses, one dose taken weekly. Inject in a single weekly injection, under the skin (subcutaneously).
  • For your weekly dose, you need to turn the dose knob all the way until it stops AND the icon is in dose window.
  • After 4 doses, throw away (discard) the Pen, including the unused medicine. The Pen will prevent you from dialing a full dose after you have given yourself 4 weekly doses. Do not inject the leftover medicine. Do not transfer Zepbound from your Pen into a syringe.
  • Do not share your Zepbound Pen with other people, even if the pen needle has been changed. You may give other people a serious infection or get a serious infection from them.
  • People who are blind or have vision problems should not use the Pen without help from a person trained to use the Pen.
  • Guide to parts
  • Parts of the Zepbound Pen
  • Supplies needed to give your injection
  • Zepbound KwikPen KwikPen-compatible Pen Needle (not included) Alcohol swab Gauze or cotton ball FDA-cleared sharps disposal container or household container
  • Preparing to inject Zepbound
  • Step 1: Wash your hands with soap and water.
  • Step 2: Pull the Pen cap straight off. Inspect the Pen and label. Do not use if: – the medicine name or dose strength does not match your prescription. – the Pen is expired (EXP) or looks damaged. – the medicine has been frozen, has particles, is cloudy, or is discolored. Zepbound should be colorless to slightly yellow.
  • Step 3: Wipe the red inner seal with an alcohol swab.
  • Step 4: Select a new pen needle. Always use a new pen needle for each injection to help prevent infections and blocked needles. Pull off the paper tab from the outer needle shield.
  • Step 5: Push the capped pen needle straight onto the Pen and twist the pen needle on until it is tight.
  • Step 6: Pull off the outer needle shield and keep it. This will be reused. Pull off the inner needle shield. Put it in your household trash.
  • a. Outer needle shield b. Inner needle shield
  • Priming your Pen
  • Prime before each weekly injection. Priming removes air from the cartridge and makes sure that your Pen is working correctly.
  • Step 7: Slowly turn the dose knob until you hear 2 clicks and the extended line is shown in the dose window. This is the prime position. It can be corrected by turning the dose knob in either direction until the prime position lines up to the dose indicator.
  • Step 8: Hold your Pen with the needle pointing up. Tap the cartridge holder gently to collect air bubbles at the top.
  • Step 9: Release some medicine into the air by pushing the dose knob in until it stops, then slowly count to 5 while holding the dose knob. The icon must be shown in the dose window. Do not inject into your body. Your Pen has been primed if a small amount (a drop) of medicine comes out of the tip of the pen needle. – If you do not see medicine, repeat steps 7-9, no more than 2 additional times. – If you still do not see medicine, then change the pen needle and repeat steps 7-9, no more than 1 additional time. – If you still do not see medicine, contact Lilly at 1-800-LillyRx (1-800-545-5979).
  • Injecting Zepbound
  • Step 10: Choose an injection site. You or another person can inject the medicine in your thigh or stomach (abdomen) at least 2 inches from the belly button. Another person should give you the injection in the back of your upper arm. Change (rotate) your injection site each week. You may use the same area of your body but be sure to choose a different injection site in that area.
  • a. Front b. Back
  • Step 11: Turn the dose knob all the way until it stops AND the icon is in the dose window. This is your weekly dose. Do not count clicks as you select the dose.
  • Step 12: Insert the needle into your skin. Inject the medicine by pushing the dose knob in until it stops then slowly count to 5 while holding the dose knob. You may notice the plunger moving with each injection. The icon must be shown in the dose window before removing the needle.
  • Step 13: Pull the needle out of your skin. A drop of medicine on the needle tip is normal. It will not affect your dose. Confirm the icon is in the dose window. If you see the icon in the dose window, you have received the full dose. If you do not see the icon in the dose window, insert the needle back into your skin and finish your injection. Do not redial the dose. If you still do not think you received the full dose, do not start over or repeat the injection. See “Troubleshooting” section for more information.
  • After your Zepbound injection
  • Step 14: If you see blood after you pull the needle out of your skin, lightly press the injection site with gauze or a cotton ball. Do not rub the injection site.
  • Step 15: Carefully replace the outer needle shield.
  • Step 16: Unscrew the capped needle and put the needle in a sharps container (see “Disposing of Zepbound KwikPen and pen needles” section). Do not store the Pen with the needle attached to prevent leaking, blocking the needle, and air from entering the Pen.
  • Step 17: Replace the Pen cap. Do not store the Pen without the Pen cap attached.
  • Storing your Zepbound KwikPen
  • Unused Pens:
  • Store unused Pens in the refrigerator between 36°F to 46°F (2°C to 8°C).
  • Unused Pens may be used until the expiration date (EXP) printed on the label if the Pen has been kept in the refrigerator.
  • Do not freeze your Pen. Throw away (discard) the Pen if it has been frozen.
  • Used Pens:
  • You may store your used Pen at room temperature up to 86°F (30°C) after your injection.
  • Keep away from heat and light.
  • Keep your Pen and needles out of the sight and reach of children.
  • Throw away the Pen 30 days after first use even though the Pen has medicine left in it.
  • Throw away the Pen after receiving 4 weekly doses. Attempting to inject any leftover medicine could result in an incomplete dose even though the Pen still has medicine left in it.
  • Disposing of Zepbound KwikPen and pen needles
  • Put your used pen needles in an FDA-cleared sharps disposal container right away after use.
  • Do not throw away (discard) loose pen needles in your household trash.
  • Discard the used Pen in your household trash or FDA-cleared sharps disposal container after you have removed the needle.
  • If you do not have an FDA-cleared sharps disposal container, you may use a household container that is: – made of a heavy-duty plastic, – can be closed with a tight-fitting, puncture-resistant lid, without sharps being able to come out, – upright and stable during use, – leak-resistant, and – properly labeled to warn of hazardous waste inside the container.
  • When your sharps disposal container is almost full, you will need to follow your community guidelines for the right way to dispose of your sharps disposal container. There may be state or local laws about how you should throw away (discard) used needles. For more information about safe sharps disposal, and for specific information about sharps disposal in the state you live in, go to the FDA's website at: http://www.fda.gov/safesharpsdisposal.
  • Do not dispose of your used sharps disposal container in your household trash unless your community guidelines permit this. Do not recycle your used sharps disposal container.
  • Troubleshooting
  • If you cannot remove the Pen cap, gently twist the Pen cap back and forth, and then pull the Pen cap straight off.
  • If the dose knob is hard to push: – pushing the dose knob more slowly will make it easier to inject. – your needle may be blocked. Put on a new pen needle and prime the Pen. – you may have dust, food, or liquid inside the Pen. Throw the Pen away and get a new Pen.
  • If the Pen prevents you from turning the dose knob until the is in the dose window: – Throw away (discard) the Pen, including the unused medicine. There may not be enough medicine left in the pen to give a full dose. Do not attempt to inject the leftover medicine.
  • Additional Information:
  • If you have any questions or problems with Zepbound KwikPen:
  • Call your healthcare provider Call 1-800-LillyRx (1-800-545-5979) Visit www.zepbound.com Scan this code to launch www.zepbound.com
  • Zepbound ® and KwikPen ® are registered trademarks of Eli Lilly and Company.
  • Zepbound KwikPen meets the current dose accuracy and functional requirements of ISO 11608-1.
  • ZEPKP-0002-IFU-20260121
  • Medication Calendar
  • Use Zepbound 1 time a week. Write the day of the week you choose to inject. Inject on this day each week (Example: Monday). I inject my weekly dose on the dates below.
  • (Month/Day)
Questions

Using Zepbound: common questions

How do you inject Zepbound?

Follow the FDA-approved Instructions for Use for your product, listed on this page. They differ by product: single-dose pen; single-dose vial; multiple-dose vial; multi-dose kwikpen. Your healthcare provider should show you how before your first dose.

Does Zepbound come with needles?

From its Instructions for Use: 1 syringe and 1 needle, supplied separately (for example, use a 1 mL syringe and needle as recommended by your healthcare provider) Guide to parts Vial Needle and Syringe (not included) Note: The needle and syringe are not included. Vial Needle and Syringe (not included)

Do you need to change where you inject Zepbound?

From its FDA label: Rotate injection sites with each dose.

GLPcompare is an informational data platform, not a medical provider or pharmacy. Nothing here is medical advice, a diagnosis, or a recommendation to start, stop, or change any treatment. Data is aggregated from public sources and can be incomplete or out of date. Always confirm with a licensed clinician and the current FDA label.