From each FDA label

Do GLP-1s cause low blood pressure?

No current GLP-1 label prints a rate for low blood pressure in its main trial table.

Read from each manufacturer's FDA label on DailyMed. The newest revision saying anything on this is Aug 28, 2026.

Word for word

What each label says about low blood pressure

Sentences from each label's warnings and side effect sections. Only cross-references are removed.

Wegovy

  • Adverse reactions related to hypotension (hypotension, orthostatic hypotension, and decreased blood pressure) were reported in 1.3% of Wegovy-treated adult patients versus 0.4% of placebo-treated patients and syncope was reported in 0.8% of Wegovy-treated patients versus 0.2% of placebo-treated patients in clinical trials for weight reduction.
  • Hypotension and orthostatic hypotension were more frequently seen in patients on concomitant antihypertensive therapy.
  • In a clinical trial in pediatric patients aged 12 years and older for weight reduction, hypotension was reported in 2.3% of Wegovy-treated patients versus 0% in placebo-treated patients.

Label revised Jun 18, 2026. DailyMed

Zepbound

  • In a pool of Study 1 and 2, hypotension occurred more frequently among patients taking Zepbound (1.6%) than patients taking placebo (0.1%).
  • Hypotension was more frequently seen in Zepbound-treated patients on concomitant antihypertensive therapy (2.2%) compared to Zepbound-treated patients not on antihypertensive therapy (1.2%).
  • Hypotension also occurred in association with gastrointestinal adverse events and dehydration.

Label revised Aug 28, 2026. DailyMed

Foundayo

  • In a pool of Trials 1 and 2, hypotension occurred more frequently among patients taking Foundayo (2%) than patients taking placebo (0.5%).
  • Hypotension was more frequently seen in Foundayo-treated patients on concomitant antihypertensive therapy (4%) compared to Foundayo-treated patients not on antihypertensive therapy (1%).

Label revised Jul 29, 2026. DailyMed

Saxenda

  • Cases of anaphylactic reactions with additional symptoms such as hypotension, palpitations, dyspnea, and edema have been reported with marketed use of liraglutide.
  • Adverse reactions related to hypotension (hypotension, orthostatic hypotension, circulatory collapse, and decreased blood pressure) were reported more frequently with Saxenda (1.1%) compared with placebo (0.5%) in Saxenda clinical trials in adults.
  • One of the Saxenda-treated patients had hypotension associated with gastrointestinal adverse reactions and renal failure.

Label revised Feb 25, 2026. DailyMed

Ozempic, Rybelsus and Ozempic tablets, Mounjaro, Trulicity, Victoza, Byetta: no finding on this in the sections read here.

Not from trials

Reports to FDA about low blood pressure

Counts of voluntary reports from patients and doctors. They cannot show that a medicine caused anything and cannot give a rate, and a brand used by more people draws more reports.

MedicineReports namingAll reports on it
OzempicHypotension: 473 · Syncope: 302 · Blood pressure decreased: 293 · Orthostatic hypotension: 6470,863
MounjaroSyncope: 458 · Hypotension: 380 · Blood pressure decreased: 250 · Orthostatic hypotension: 5497,440
ByettaHypotension: 236 · Blood pressure decreased: 193 · Syncope: 175 · Orthostatic hypotension: 2752,087
TrulicityHypotension: 234 · Blood pressure decreased: 190 · Syncope: 181 · Orthostatic hypotension: 2287,279
VictozaHypotension: 233 · Blood pressure decreased: 125 · Syncope: 120 · Orthostatic hypotension: 2741,462
ZepboundBlood pressure decreased: 197 · Hypotension: 159 · Syncope: 74 · Orthostatic hypotension: 1780,835
WegovySyncope: 133 · Hypotension: 123 · Blood pressure decreased: 75 · Orthostatic hypotension: 1525,993
SaxendaSyncope: 99 · Hypotension: 46 · Blood pressure decreased: 23 · Orthostatic hypotension: 67,270
Rybelsus and Ozempic tabletsHypotension: 62 · Syncope: 48 · Blood pressure decreased: 37 · Orthostatic hypotension: 37,758
FoundayoHypotension: 20 · Blood pressure decreased: 14 · Orthostatic hypotension: 2 · Syncope: 23,050

Counted through openFDA from FDA's Adverse Event Reporting System, refreshed weekly. One report can name several terms.

Updated automatically

Latest FDA label updates

Written from each source's own record as it changes. Every change on GLPcompare

Questions

Low blood pressure on a GLP-1: common questions

Does Wegovy cause low blood pressure?

Its FDA label: Adverse reactions related to hypotension (hypotension, orthostatic hypotension, and decreased blood pressure) were reported in 1.3% of Wegovy-treated adult patients versus 0.4% of placebo-treated patients and syncope was reported in 0.8% of Wegovy-treated patients versus 0.2% of placebo-treated patients in clinical trials for weight reduction. Hypotension and orthostatic hypotension were more frequently seen in patients on concomitant antihypertensive therapy.

Does Zepbound cause low blood pressure?

Its FDA label: In a pool of Study 1 and 2, hypotension occurred more frequently among patients taking Zepbound (1.6%) than patients taking placebo (0.1%). Hypotension was more frequently seen in Zepbound-treated patients on concomitant antihypertensive therapy (2.2%) compared to Zepbound-treated patients not on antihypertensive therapy (1.2%).

Does Foundayo cause low blood pressure?

Its FDA label: In a pool of Trials 1 and 2, hypotension occurred more frequently among patients taking Foundayo (2%) than patients taking placebo (0.5%). Hypotension was more frequently seen in Foundayo-treated patients on concomitant antihypertensive therapy (4%) compared to Foundayo-treated patients not on antihypertensive therapy (1%).

Does Saxenda cause low blood pressure?

Its FDA label: Cases of anaphylactic reactions with additional symptoms such as hypotension, palpitations, dyspnea, and edema have been reported with marketed use of liraglutide. Adverse reactions related to hypotension (hypotension, orthostatic hypotension, circulatory collapse, and decreased blood pressure) were reported more frequently with Saxenda (1.1%) compared with placebo (0.5%) in Saxenda clinical trials in adults.

Other side effects

Trial rates describe groups, not what one person will feel. Talk to your clinician before starting, stopping or changing a medicine.

GLPcompare is an informational data platform, not a medical provider or pharmacy. Nothing here is medical advice, a diagnosis, or a recommendation to start, stop, or change any treatment. Data is aggregated from public sources and can be incomplete or out of date. Always confirm with a licensed clinician and the current FDA label.