Head to head

Compare GLP-1 medications

Start with the brands you know, or compare active ingredients. Approved uses, formulations, prices, and study evidence stay distinct.

Choose what to compare

Compare the named products. Different brands of the same ingredient stay separate. Missing label or price details are shown explicitly.

orforglipron

semaglutide

Compare 2Foundayo vs Wegovy
From FDA and CMS records

Every approved GLP-1 side by side

Read from each FDA label, FDA's Orange Book and CMS's Part D files, and updated when they change.

BrandSoonest top doseHalf-lifeGeneric approved?Patent on the medicine toOn Medicare Part D, 2025
Ozempic2 mg from week 13about 1 weekNot yet: tentative onlyDec 5, 20312,044,798
Wegovy7.2 mg from week 21about 1 weekNoDec 5, 2031108,843
Rybelsus14 mg from day 61about one weekNoMay 2, 2034280,455
Mounjaro15 mg from week 21about 5 daysNoJun 14, 20391,592,517
Zepbound15 mg from week 21about 5-6 daysNoMay 13, 2036160,298
Foundayo17.2 mg from day 151about 29 to 49 hoursNoSep 26, 2037None listed
Victoza1.8 mg from week 3about 13 hoursYes, 8None listed6,810
Saxenda3 mg from week 5about 13 hoursYes, 3None listedNone listed
Trulicity4.5 mg from week 13about 5 daysNo, it is a biologicNot in the Orange Book582,333

How long each takes · Generics and patents · Who covers what

Compare brands

Start with a familiar pair

Product-specific labels and prices, including differences between injections and tablets.

WegovyZepbound

Semaglutide and Tirzepatide: compare the actual brands.

MounjaroOzempic

Tirzepatide and Semaglutide: compare the actual brands.

OzempicWegovy

Same ingredient (semaglutide), different approved uses.

MounjaroZepbound

Same ingredient (tirzepatide), different approved uses.

OzempicRybelsus

Same ingredient (semaglutide), different approved uses.

SaxendaWegovy

Liraglutide and Semaglutide: compare the actual brands.

WegovyWegovy HD

Same ingredient (semaglutide), different approved uses.

MounjaroWegovy

Tirzepatide and Semaglutide: compare the actual brands.

OzempicZepbound

Semaglutide and Tirzepatide: compare the actual brands.

SaxendaVictoza

Same ingredient (liraglutide), different approved uses.

OzempicTrulicity

Semaglutide and Dulaglutide: compare the actual brands.

MounjaroTrulicity

Tirzepatide and Dulaglutide: compare the actual brands.

RybelsusWegovy

Same ingredient (semaglutide), different approved uses.

SaxendaZepbound

Liraglutide and Tirzepatide: compare the actual brands.

TrulicityVictoza

Dulaglutide and Liraglutide: compare the actual brands.

FoundayoWegovy

Orforglipron and Semaglutide: compare the actual brands.

FoundayoZepbound

Orforglipron and Tirzepatide: compare the actual brands.

Browse all 15 approved-ingredient pairs

Ingredient comparisons cover multiple brands and formulations. Trial results include the studied dose and population.

SemaglutideTirzepatide

Ozempic, Wegovy, Wegovy HD, Rybelsus

SemaglutideLiraglutide

Ozempic, Wegovy, Wegovy HD, Rybelsus

SemaglutideDulaglutide

Ozempic, Wegovy, Wegovy HD, Rybelsus

SemaglutideExenatide

Ozempic, Wegovy, Wegovy HD, Rybelsus

SemaglutideOrforglipron

Ozempic, Wegovy, Wegovy HD, Rybelsus

TirzepatideLiraglutide

Mounjaro, Zepbound, Victoza, Saxenda

TirzepatideDulaglutide

Mounjaro, Zepbound, Trulicity

TirzepatideExenatide

Mounjaro, Zepbound, Byetta (discontinued), Bydureon BCise (discontinued)

TirzepatideOrforglipron

Mounjaro, Zepbound, Foundayo

LiraglutideDulaglutide

Victoza, Saxenda, Trulicity

LiraglutideExenatide

Victoza, Saxenda, Byetta (discontinued), Bydureon BCise (discontinued)

LiraglutideOrforglipron

Victoza, Saxenda, Foundayo

DulaglutideExenatide

Trulicity, Byetta (discontinued), Bydureon BCise (discontinued), Generic exenatide

DulaglutideOrforglipron

Trulicity, Foundayo

ExenatideOrforglipron

Byetta (discontinued), Bydureon BCise (discontinued), Generic exenatide, Foundayo

Questions

Comparing GLP-1s: common questions

Which GLP-1 is best?

None is best for everyone: it depends on what it is for, what you tolerate and what you can get. In SURMOUNT-5, a head-to-head trial of the injections, mean weight change was −13.7% on semaglutide (Wegovy) and −20.2% on tirzepatide (Zepbound) over 72 weeks. Your prescriber weighs these against your health and history. Semaglutide vs tirzepatide, compared in full

Which GLP-1 has the most weight loss?

Compare only within a head-to-head trial, because separate trials enrolled different people. In SURMOUNT-5, a head-to-head trial of the injections, mean weight change was −13.7% on semaglutide (Wegovy) and −20.2% on tirzepatide (Zepbound) over 72 weeks. Weight loss and A1c results compared

Which GLP-1 has the fewest side effects?

No trial compares them all, and each label's rates come from its own trials. The side effects page shows each rate beside its own placebo group. GLP-1 side effects compared

GLPcompare is an informational data platform, not a medical provider or pharmacy. Nothing here is medical advice, a diagnosis, or a recommendation to start, stop, or change any treatment. Data is aggregated from public sources and can be incomplete or out of date. Always confirm with a licensed clinician and the current FDA label.